FR2513518A1 - Polysaccharide extrait du gnidia kraussiana, preparation et usages therapeutiques - Google Patents
Polysaccharide extrait du gnidia kraussiana, preparation et usages therapeutiques Download PDFInfo
- Publication number
- FR2513518A1 FR2513518A1 FR8118508A FR8118508A FR2513518A1 FR 2513518 A1 FR2513518 A1 FR 2513518A1 FR 8118508 A FR8118508 A FR 8118508A FR 8118508 A FR8118508 A FR 8118508A FR 2513518 A1 FR2513518 A1 FR 2513518A1
- Authority
- FR
- France
- Prior art keywords
- treatment
- polysaccharide
- kraussiana
- psoriasis
- asthma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004676 glycans Chemical class 0.000 title claims abstract description 8
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 8
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 8
- 201000004681 Psoriasis Diseases 0.000 title abstract description 4
- 208000006673 asthma Diseases 0.000 title abstract description 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 title abstract 2
- 206010057190 Respiratory tract infections Diseases 0.000 title 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 241001263571 Gnidia kraussiana Species 0.000 claims abstract description 3
- CGSGRJNIABXQJQ-LNCIWOMLSA-N from gnidia Chemical compound O1C(/C=C/C=C/CCCCC)(OC23C(C)=C)OC2C2C4OC4(CO)C(O)C(C(C(C)=C4)=O)(O)C4C21C(C)C3OC(=O)C1=CC=CC=C1 CGSGRJNIABXQJQ-LNCIWOMLSA-N 0.000 claims abstract 2
- 239000000419 plant extract Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 238000000502 dialysis Methods 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 abstract description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 3
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 abstract description 3
- 230000007815 allergy Effects 0.000 abstract description 3
- 239000000284 extract Substances 0.000 abstract description 3
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract description 2
- 208000006313 Delayed Hypersensitivity Diseases 0.000 abstract description 2
- 201000004624 Dermatitis Diseases 0.000 abstract description 2
- 229930091371 Fructose Natural products 0.000 abstract description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract description 2
- 239000005715 Fructose Substances 0.000 abstract description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 abstract description 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 abstract description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract description 2
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 abstract description 2
- 208000010668 atopic eczema Diseases 0.000 abstract description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 2
- 230000001684 chronic effect Effects 0.000 abstract description 2
- 229930182830 galactose Natural products 0.000 abstract description 2
- 239000008103 glucose Substances 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000004262 Food Hypersensitivity Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000020932 food allergy Nutrition 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 108010074605 gamma-Globulins Proteins 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 3
- 208000008190 Agammaglobulinemia Diseases 0.000 description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- -1 diterpenoid esters Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 210000004180 plasmocyte Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000012264 purified product Substances 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 231100000027 toxicology Toxicity 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010012741 Diarrhoea haemorrhagic Diseases 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000781 anti-lymphocytic effect Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000003136 immunomodifying effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 208000025036 lymphosarcoma Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000017807 phytochemicals Nutrition 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8118508A FR2513518A1 (fr) | 1981-09-29 | 1981-09-29 | Polysaccharide extrait du gnidia kraussiana, preparation et usages therapeutiques |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8118508A FR2513518A1 (fr) | 1981-09-29 | 1981-09-29 | Polysaccharide extrait du gnidia kraussiana, preparation et usages therapeutiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2513518A1 true FR2513518A1 (fr) | 1983-04-01 |
| FR2513518B1 FR2513518B1 (enExample) | 1984-02-17 |
Family
ID=9262647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8118508A Granted FR2513518A1 (fr) | 1981-09-29 | 1981-09-29 | Polysaccharide extrait du gnidia kraussiana, preparation et usages therapeutiques |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2513518A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677198A (en) * | 1983-11-22 | 1987-06-30 | Gist-Brocades N.V. | Process for the preparation of oligosaccharides-containing products from biomass |
| FR2597752A1 (fr) * | 1986-04-24 | 1987-10-30 | Tubery Pierre | Effet de synergie entre la senegenine et le polysaccharide extrait du gnidia kraussiana dans le traitement de certaines allergies |
| EP0304347A3 (en) * | 1987-07-10 | 1989-03-08 | Etablissements Guyomarc'h S.A. | Polysaccharides extracted from plants and useful as medicines and food additives |
| US20140154218A1 (en) * | 2010-03-24 | 2014-06-05 | Morishita Jintan Co., Ltd. | Anti-allergic agent |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2871235A (en) * | 1952-08-29 | 1959-01-27 | Jilovice Vladimir Jan Hlous De | Process for obtaining polysaccharide material from plants of the genus cecropia |
| FR7333M (enExample) * | 1967-12-08 | 1969-10-13 |
-
1981
- 1981-09-29 FR FR8118508A patent/FR2513518A1/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2871235A (en) * | 1952-08-29 | 1959-01-27 | Jilovice Vladimir Jan Hlous De | Process for obtaining polysaccharide material from plants of the genus cecropia |
| FR7333M (enExample) * | 1967-12-08 | 1969-10-13 |
Non-Patent Citations (1)
| Title |
|---|
| CA1975 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677198A (en) * | 1983-11-22 | 1987-06-30 | Gist-Brocades N.V. | Process for the preparation of oligosaccharides-containing products from biomass |
| FR2597752A1 (fr) * | 1986-04-24 | 1987-10-30 | Tubery Pierre | Effet de synergie entre la senegenine et le polysaccharide extrait du gnidia kraussiana dans le traitement de certaines allergies |
| EP0304347A3 (en) * | 1987-07-10 | 1989-03-08 | Etablissements Guyomarc'h S.A. | Polysaccharides extracted from plants and useful as medicines and food additives |
| US20140154218A1 (en) * | 2010-03-24 | 2014-06-05 | Morishita Jintan Co., Ltd. | Anti-allergic agent |
| EP2551283A4 (en) * | 2010-03-24 | 2015-04-22 | Morishita Jintan Co | ANTIALLERGENIC ACTIVE SUBSTANCE |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2513518B1 (enExample) | 1984-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse | ||
| RC | Opposition against decision of lapse | ||
| DA | Annulment of decision of lapse | ||
| ST | Notification of lapse |