FR2508043B1 - Derives d'aporphine efficaces par voie orale et leur procede de fabrication - Google Patents

Derives d'aporphine efficaces par voie orale et leur procede de fabrication

Info

Publication number
FR2508043B1
FR2508043B1 FR8210734A FR8210734A FR2508043B1 FR 2508043 B1 FR2508043 B1 FR 2508043B1 FR 8210734 A FR8210734 A FR 8210734A FR 8210734 A FR8210734 A FR 8210734A FR 2508043 B1 FR2508043 B1 FR 2508043B1
Authority
FR
France
Prior art keywords
aporphin
oral
derivatives
effective
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8210734A
Other languages
English (en)
French (fr)
Other versions
FR2508043A1 (fr
Inventor
John L Neumeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northeastern University Boston
Original Assignee
Northeastern University Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/379,557 external-priority patent/US4543256A/en
Application filed by Northeastern University Boston filed Critical Northeastern University Boston
Publication of FR2508043A1 publication Critical patent/FR2508043A1/fr
Application granted granted Critical
Publication of FR2508043B1 publication Critical patent/FR2508043B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8210734A 1981-06-18 1982-06-18 Derives d'aporphine efficaces par voie orale et leur procede de fabrication Expired FR2508043B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27477281A 1981-06-18 1981-06-18
US34684182A 1982-02-08 1982-02-08
US35891782A 1982-03-17 1982-03-17
US35891882A 1982-03-17 1982-03-17
US06/379,557 US4543256A (en) 1982-03-17 1982-05-18 (-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers

Publications (2)

Publication Number Publication Date
FR2508043A1 FR2508043A1 (fr) 1982-12-24
FR2508043B1 true FR2508043B1 (fr) 1987-04-30

Family

ID=27540584

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8210734A Expired FR2508043B1 (fr) 1981-06-18 1982-06-18 Derives d'aporphine efficaces par voie orale et leur procede de fabrication

Country Status (8)

Country Link
CA (1) CA1270253A (it)
DE (1) DE3222840A1 (it)
DK (1) DK272182A (it)
FR (1) FR2508043B1 (it)
GB (1) GB2105323B (it)
IE (1) IE53161B1 (it)
IT (1) IT1191200B (it)
NL (1) NL8202467A (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012574A1 (en) * 1989-04-25 1990-11-01 Northeastern University Dopamine agonist compounds
AU4536599A (en) 1999-06-21 2001-01-09 Geochemistry Research Limited Metal-rich silica products from geothermal and synthetic aqueous systems nen wie
US9359303B2 (en) 2009-04-21 2016-06-07 Purdue Research Foundation Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor
WO2020070099A1 (en) 2018-10-02 2020-04-09 H. Lundbeck A/S Administration of catecholamine prodrugs in combination with a 5-ht2b antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
US3810987A (en) * 1972-06-12 1974-05-14 Merck & Co Inc Blood pressure lowering method using an aporphine

Also Published As

Publication number Publication date
CA1270253A (en) 1990-06-12
DK272182A (da) 1982-12-19
IT8267776A0 (it) 1982-06-17
FR2508043A1 (fr) 1982-12-24
GB2105323A (en) 1983-03-23
IE821441L (en) 1982-12-18
NL8202467A (nl) 1983-01-17
IT1191200B (it) 1988-02-24
IE53161B1 (en) 1988-08-03
DE3222840A1 (de) 1983-05-05
GB2105323B (en) 1985-12-11

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Legal Events

Date Code Title Description
ST Notification of lapse