IE821441L - Orally effective aporphine compounds - Google Patents
Orally effective aporphine compoundsInfo
- Publication number
- IE821441L IE821441L IE821441A IE144182A IE821441L IE 821441 L IE821441 L IE 821441L IE 821441 A IE821441 A IE 821441A IE 144182 A IE144182 A IE 144182A IE 821441 L IE821441 L IE 821441L
- Authority
- IE
- Ireland
- Prior art keywords
- substituted
- phenyl
- lower alkyl
- alkynyl
- alkenyl
- Prior art date
Links
- 150000008441 aporphines Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A method for providing orally effective aporphine compounds, and new compounds which are orally effective in the prevention and treatment of duodenal ulcers and in the treatment of neurological and psychiatric disorders having the following formula: <IMAGE> wherein R1 is lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, lower alkenyl, subsubstituted lower alkenyl, lower alkynyl, substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl and phenyl lower alkynyl, R2 and R3 are hydrogen, methyl, lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl and phenyl lower alkynyl and R4 is hydrogen, hydroxy, -O-R5 and <IMAGE> and R5 is methyl and lower alkyl. Particularly effective are compounds wherein R4 is hydrogen.
[GB2105323A]
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27477281A | 1981-06-18 | 1981-06-18 | |
| US34684182A | 1982-02-08 | 1982-02-08 | |
| US35891782A | 1982-03-17 | 1982-03-17 | |
| US35891882A | 1982-03-17 | 1982-03-17 | |
| US06/379,557 US4543256A (en) | 1982-03-17 | 1982-05-18 | (-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE821441L true IE821441L (en) | 1982-12-18 |
| IE53161B1 IE53161B1 (en) | 1988-08-03 |
Family
ID=27540584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1441/82A IE53161B1 (en) | 1981-06-18 | 1982-06-17 | Orally effective aporphine compounds |
Country Status (8)
| Country | Link |
|---|---|
| CA (1) | CA1270253A (en) |
| DE (1) | DE3222840A1 (en) |
| DK (1) | DK272182A (en) |
| FR (1) | FR2508043B1 (en) |
| GB (1) | GB2105323B (en) |
| IE (1) | IE53161B1 (en) |
| IT (1) | IT1191200B (en) |
| NL (1) | NL8202467A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012574A1 (en) * | 1989-04-25 | 1990-11-01 | Northeastern University | Dopamine agonist compounds |
| AU4536599A (en) | 1999-06-21 | 2001-01-09 | Geochemistry Research Limited | Metal-rich silica products from geothermal and synthetic aqueous systems nen wie |
| US9359303B2 (en) | 2009-04-21 | 2016-06-07 | Purdue Research Foundation | Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor |
| WO2020070099A1 (en) | 2018-10-02 | 2020-04-09 | H. Lundbeck A/S | Administration of catecholamine prodrugs in combination with a 5-ht2b antagonist |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3717643A (en) * | 1967-05-04 | 1973-02-20 | Sterling Drug Inc | N-substituted-norapomorphines |
| US3810987A (en) * | 1972-06-12 | 1974-05-14 | Merck & Co Inc | Blood pressure lowering method using an aporphine |
-
1982
- 1982-06-17 DK DK272182A patent/DK272182A/en not_active Application Discontinuation
- 1982-06-17 IT IT67776/82A patent/IT1191200B/en active
- 1982-06-17 NL NL8202467A patent/NL8202467A/en not_active Application Discontinuation
- 1982-06-17 IE IE1441/82A patent/IE53161B1/en unknown
- 1982-06-17 CA CA000405440A patent/CA1270253A/en not_active Expired
- 1982-06-18 GB GB08217644A patent/GB2105323B/en not_active Expired
- 1982-06-18 DE DE19823222840 patent/DE3222840A1/en not_active Withdrawn
- 1982-06-18 FR FR8210734A patent/FR2508043B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2105323B (en) | 1985-12-11 |
| DK272182A (en) | 1982-12-19 |
| IT1191200B (en) | 1988-02-24 |
| GB2105323A (en) | 1983-03-23 |
| NL8202467A (en) | 1983-01-17 |
| FR2508043B1 (en) | 1987-04-30 |
| IT8267776A0 (en) | 1982-06-17 |
| FR2508043A1 (en) | 1982-12-24 |
| IE53161B1 (en) | 1988-08-03 |
| CA1270253A (en) | 1990-06-12 |
| DE3222840A1 (en) | 1983-05-05 |
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