FR2508035B1 - - Google Patents

Info

Publication number
FR2508035B1
FR2508035B1 FR8112312A FR8112312A FR2508035B1 FR 2508035 B1 FR2508035 B1 FR 2508035B1 FR 8112312 A FR8112312 A FR 8112312A FR 8112312 A FR8112312 A FR 8112312A FR 2508035 B1 FR2508035 B1 FR 2508035B1
Authority
FR
France
Prior art keywords
atom
alkyl group
lower alkyl
group
heterocycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8112312A
Other languages
English (en)
French (fr)
Other versions
FR2508035A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9259785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2508035(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR8112312A priority Critical patent/FR2508035A1/fr
Priority to ES512842A priority patent/ES8303293A1/es
Priority to DE8282401129T priority patent/DE3263734D1/de
Priority to EP82401129A priority patent/EP0068999B1/fr
Priority to AT82401129T priority patent/ATE13422T1/de
Priority to AU85086/82A priority patent/AU550774B2/en
Priority to CA000405651A priority patent/CA1202639A/fr
Priority to US06/390,810 priority patent/US4478836A/en
Priority to JP57109097A priority patent/JPS584752A/ja
Priority to ZA824453A priority patent/ZA824453B/xx
Publication of FR2508035A1 publication Critical patent/FR2508035A1/fr
Publication of FR2508035B1 publication Critical patent/FR2508035B1/fr
Application granted granted Critical
Priority to LU90410C priority patent/LU90410I2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR8112312A 1981-06-23 1981-06-23 Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central Granted FR2508035A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR8112312A FR2508035A1 (fr) 1981-06-23 1981-06-23 Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
ES512842A ES8303293A1 (es) 1981-06-23 1982-06-04 "procedimiento de preparar derivados carboxamidicos".
DE8282401129T DE3263734D1 (en) 1981-06-23 1982-06-21 Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (z), their preparation and their use as medicines in the treatment of disorders of the central nervous system
EP82401129A EP0068999B1 (fr) 1981-06-23 1982-06-21 Dérivés d'aryl-1 aminométhyl-2 cyclopropanes carboxamides (Z), leur préparation et leur application en tant que médicaments utiles dans le traitement des troubles du système nerveux central
AT82401129T ATE13422T1 (de) 1981-06-23 1982-06-21 Derivate von 1-aryl-2-aminomethyl-cyclopropancarboxamiden (z), ihre herstellung und ihre verwendung fuer die behandlung von stoerungen des zentralnervensystems.
CA000405651A CA1202639A (fr) 1981-06-23 1982-06-22 Derives d'aryl-1 aminomethyl-2 cyclopropanes carboxamides (z) et leur preparation
AU85086/82A AU550774B2 (en) 1981-06-23 1982-06-22 1-aryl-2-aminomethyl cyclopropane carboxylates
US06/390,810 US4478836A (en) 1981-06-23 1982-06-22 1-Aryl 2-aminomethyl cyclopropane carboxyamide (Z) derivatives and their use as useful drugs in the treatment of disturbances of the central nervous system
JP57109097A JPS584752A (ja) 1981-06-23 1982-06-23 カルボキシアミド誘導体及びその製造法
ZA824453A ZA824453B (en) 1981-06-23 1982-06-23 1-aryl 2-aminomethyl cyclopropane carboxamide (z) derivatives their preparation and their use as useful drugs in the treatment of disturbances of the central nervous system
LU90410C LU90410I2 (fr) 1981-06-23 1999-06-30 Milnacipran (chlorhydrate)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8112312A FR2508035A1 (fr) 1981-06-23 1981-06-23 Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central

Publications (2)

Publication Number Publication Date
FR2508035A1 FR2508035A1 (fr) 1982-12-24
FR2508035B1 true FR2508035B1 (enExample) 1984-06-29

Family

ID=9259785

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8112312A Granted FR2508035A1 (fr) 1981-06-23 1981-06-23 Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central

Country Status (11)

Country Link
US (1) US4478836A (enExample)
EP (1) EP0068999B1 (enExample)
JP (1) JPS584752A (enExample)
AT (1) ATE13422T1 (enExample)
AU (1) AU550774B2 (enExample)
CA (1) CA1202639A (enExample)
DE (1) DE3263734D1 (enExample)
ES (1) ES8303293A1 (enExample)
FR (1) FR2508035A1 (enExample)
LU (1) LU90410I2 (enExample)
ZA (1) ZA824453B (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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FR2581059B1 (fr) * 1985-04-25 1988-04-22 Pf Medicament Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z)
FR2581060B1 (fr) * 1985-04-25 1988-07-01 Pf Medicament Procede industriel d'obtention du midalcipran
EP0747348A4 (en) * 1994-02-22 1999-07-07 Asahi Chemical Ind AMINOALKYLCYCLOPROPAN DERIVATIVES
CA2134038C (en) * 1994-06-16 1997-06-03 David Taiwai Wong Potentiation of drug response
EP0714663A3 (en) 1994-11-28 1997-01-15 Lilly Co Eli Potentiation of drug responses by serotonin 1A receptor antagonists
PT759299E (pt) * 1995-08-16 2000-09-29 Lilly Co Eli Potenciacao da resposta de serotonina
FR2752732B1 (fr) * 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
CN103288815A (zh) * 2001-10-12 2013-09-11 阿泽范药品公司 β-内酰胺后叶加压素V1a拮抗剂
US20040034101A1 (en) * 2001-11-05 2004-02-19 Cypress Bioscience, Inc. Treatment and prevention of depression secondary to pain (DSP)
US6635675B2 (en) * 2001-11-05 2003-10-21 Cypress Bioscience, Inc. Method of treating chronic fatigue syndrome
US6602911B2 (en) 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
EP1499309A4 (en) * 2002-04-24 2008-05-28 Cypress Bioscience Inc PREVENTION AND TREATMENT OF FUNCTIONAL SOMATIC DISEASES, INCLUDING STRESS-BASED DISEASES
WO2004039320A2 (en) * 2002-10-25 2004-05-13 Collegium Pharmaceutical, Inc. STEREOISOMERS OF p-HYDROXY-MILNACIPRAN, AND METHODS OF USE THEREOF
FR2851163B1 (fr) * 2003-02-14 2007-04-27 Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament
SI1601349T1 (sl) * 2003-02-14 2008-10-31 Pf Medicament Uporaba enantiomera milnaciprana za pripravo zdravila
EP1620083A2 (en) * 2003-04-18 2006-02-01 Pharmacia & Upjohn Company LLC Combination therapies
EP1656349B1 (en) 2003-08-15 2011-10-12 H. Lundbeck A/S Cyclopropyl derivatives as nk3 receptor antagonists
JP4713474B2 (ja) * 2003-08-15 2011-06-29 ハー・ルンドベック・アクチエゼルスカベット Ｎｋ３受容体アンタゴニストとしてのシクロプロピル誘導体
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
WO2005102366A2 (en) * 2004-04-19 2005-11-03 Philip Maxwell Satow Lithium combinations, and uses related thereto
JP4418717B2 (ja) * 2004-06-24 2010-02-24 住友化学株式会社 （ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法
CA2601709C (en) 2005-03-22 2017-02-14 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids
AU2006239922A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-HT2c agonists
MX2007012883A (es) * 2005-04-22 2007-12-10 Wyeth Corp Derivados de dihidrobenzofurano y usos de los mismos.
BRPI0610037A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de dihidrobenzofurano e uso dos mesmos
WO2006132307A1 (ja) * 2005-06-10 2006-12-14 Pierre Fabre Medicament S.A. 安定化されたミルナシプラン製剤
SG163588A1 (en) * 2005-07-08 2010-08-30 Braincells Inc Methods for identifying agents and conditions that modulate neurogenesis
EP1910346B1 (en) * 2005-07-19 2019-02-27 Azevan Pharmaceuticals, Inc. Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonist
WO2007025144A1 (en) * 2005-08-24 2007-03-01 University Of Illinois - Chicago 5-ht2c receptor agonists as anorectic agents
US7994220B2 (en) * 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AU2007208681B2 (en) * 2006-01-27 2010-04-08 Asahi Kasei Pharma Corporation Medicine for transnasal administration
US20080319083A1 (en) * 2006-01-27 2008-12-25 Asahi Kasei Pharma Corporation Medicine for transnasal administration
FR2912057B1 (fr) * 2007-02-07 2009-04-17 Sanofi Aventis Sa Composition pharmaceutique contenant en association le saredutant et un inhibiteur selectif de la recapture de la serotonine ou un inhibiteur de la recapture de la serotonine/norepinephrine
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
RU2008135326A (ru) * 2006-03-24 2010-04-27 Вайет (Us) Терапевтические композиции для лечения депрессии
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
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MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
WO2008034032A2 (en) * 2006-09-14 2008-03-20 Azevan Pharmaceuticals, Inc. Beta-lactam cannabinoid receptor modulators
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080167363A1 (en) * 2006-12-28 2008-07-10 Braincells, Inc Modulation of Neurogenesis By Melatoninergic Agents
AU2008204800A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation of neurogenesis with use of modafinil
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US20090069431A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched milnacipran
WO2009128058A1 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
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FR2941454B1 (fr) 2009-01-29 2011-04-01 Pf Medicament Proced de synthese du (1s,2r)-milnacipran
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US20100274050A1 (en) * 2009-04-23 2010-10-28 Glenmark Generics Limited Solid milnacipran and process for the preparation of the same
WO2010129689A1 (en) * 2009-05-05 2010-11-11 Forest Laboratories Holdings Limited Milnacipran formulations
MX2012001393A (es) 2009-08-05 2012-08-03 Lupin Ltd Composiciones farmacéuticas de liberación controlada de milnacipran.
JP2013510176A (ja) 2009-11-06 2013-03-21 ピエール ファーブル メディカモン （１ｓ，２ｒ）−２−（アミノメチル）−ｎ，ｎ−ジエチル−１−フェニルシクロプロパンカルボキサミドの新規結晶形態
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JP2013536832A (ja) 2010-08-30 2013-09-26 ルピン・リミテッド ミルナシプランの制御放出医薬組成物
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
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CA570688A (en) * 1959-02-17 E. Speeter Merrill Antispasmodic substituted amines
CA619080A (en) * 1961-04-25 The Upjohn Company N-SUBSTITUTED-.alpha.-(TERTIARY-AMINOALKYL)-.alpha.-PHENYLACETAMIDES
GB1415541A (en) 1972-11-30 1975-11-26 Hexachimie 1-amino-methyl-2,2-diarylcyclopropanecarboxamide

Also Published As

Publication number Publication date
JPS584752A (ja) 1983-01-11
AU8508682A (en) 1983-01-06
EP0068999B1 (fr) 1985-05-22
LU90410I2 (fr) 1999-08-31
DE3263734D1 (en) 1985-06-27
JPS6323186B2 (enExample) 1988-05-16
ES512842A0 (es) 1983-03-01
AU550774B2 (en) 1986-04-10
ES8303293A1 (es) 1983-03-01
ZA824453B (en) 1983-04-27
CA1202639A (fr) 1986-04-01
EP0068999A1 (fr) 1983-01-05
ATE13422T1 (de) 1985-06-15
FR2508035A1 (fr) 1982-12-24
US4478836A (en) 1984-10-23

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Legal Events

Date Code Title Description
TP Transmission of property
CP Supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: MILNACIPRAN HYDROCLORHYDE; NAT. REGISTRATION NO/DATE: NL21356 19961206; FIRST REGISTRATION: PT - 7528 19940225

Spc suppl protection certif: 97C0010

Filing date: 19970228

TP Transmission of property
CP Supplementary protection certificate (spc) filed

Free format text: 97C0010, 970228

CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: 97C0010, 970228

CP Supplementary protection certificate (spc) filed
CY Supplementary certificate of protection granted (eec regulation of 18 june 1992)

Free format text: 97C0010, 19970228, EXPIRES: 20060622