DE3263734D1 - Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (z), their preparation and their use as medicines in the treatment of disorders of the central nervous system - Google Patents

Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (z), their preparation and their use as medicines in the treatment of disorders of the central nervous system

Info

Publication number
DE3263734D1
DE3263734D1 DE8282401129T DE3263734T DE3263734D1 DE 3263734 D1 DE3263734 D1 DE 3263734D1 DE 8282401129 T DE8282401129 T DE 8282401129T DE 3263734 T DE3263734 T DE 3263734T DE 3263734 D1 DE3263734 D1 DE 3263734D1
Authority
DE
Germany
Prior art keywords
aryl
atom
alkyl group
lower alkyl
nervous system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282401129T
Other languages
German (de)
English (en)
Inventor
Gilbert Mouzin
Henri Cousse
Bernard Bonnaud
Michel Morre
Antoine Stenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9259785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3263734(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Application granted granted Critical
Publication of DE3263734D1 publication Critical patent/DE3263734D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8282401129T 1981-06-23 1982-06-21 Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (z), their preparation and their use as medicines in the treatment of disorders of the central nervous system Expired DE3263734D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8112312A FR2508035A1 (fr) 1981-06-23 1981-06-23 Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central

Publications (1)

Publication Number Publication Date
DE3263734D1 true DE3263734D1 (en) 1985-06-27

Family

ID=9259785

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282401129T Expired DE3263734D1 (en) 1981-06-23 1982-06-21 Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (z), their preparation and their use as medicines in the treatment of disorders of the central nervous system

Country Status (11)

Country Link
US (1) US4478836A (enExample)
EP (1) EP0068999B1 (enExample)
JP (1) JPS584752A (enExample)
AT (1) ATE13422T1 (enExample)
AU (1) AU550774B2 (enExample)
CA (1) CA1202639A (enExample)
DE (1) DE3263734D1 (enExample)
ES (1) ES512842A0 (enExample)
FR (1) FR2508035A1 (enExample)
LU (1) LU90410I2 (enExample)
ZA (1) ZA824453B (enExample)

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FR2851163B1 (fr) 2003-02-14 2007-04-27 Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament
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EP2343073A3 (en) 2003-12-11 2011-10-12 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
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JP4418717B2 (ja) * 2004-06-24 2010-02-24 住友化学株式会社 （ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法
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JP2008538577A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
AU2006239922A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-HT2c agonists
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WO2007025144A1 (en) * 2005-08-24 2007-03-01 University Of Illinois - Chicago 5-ht2c receptor agonists as anorectic agents
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US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2007086493A1 (ja) * 2006-01-27 2007-08-02 Asahi Kasei Pharma Corporation 経鼻投与用薬剤
US20080319083A1 (en) * 2006-01-27 2008-12-25 Asahi Kasei Pharma Corporation Medicine for transnasal administration
FR2912057B1 (fr) * 2007-02-07 2009-04-17 Sanofi Aventis Sa Composition pharmaceutique contenant en association le saredutant et un inhibiteur selectif de la recapture de la serotonine ou un inhibiteur de la recapture de la serotonine/norepinephrine
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
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US20090069431A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched milnacipran
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WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
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US20100274050A1 (en) * 2009-04-23 2010-10-28 Glenmark Generics Limited Solid milnacipran and process for the preparation of the same
WO2010129689A1 (en) * 2009-05-05 2010-11-11 Forest Laboratories Holdings Limited Milnacipran formulations
US9173845B2 (en) 2009-08-05 2015-11-03 Lupin Limited Controlled release pharmaceutical compositions of milnacipran
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US8916194B2 (en) 2010-08-30 2014-12-23 Lupin Limited Controlled release pharmaceutical compositions of milnacipran
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* Cited by examiner, † Cited by third party
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CA619080A (en) * 1961-04-25 The Upjohn Company N-SUBSTITUTED-.alpha.-(TERTIARY-AMINOALKYL)-.alpha.-PHENYLACETAMIDES
CA570688A (en) * 1959-02-17 E. Speeter Merrill Antispasmodic substituted amines
GB1415541A (en) * 1972-11-30 1975-11-26 Hexachimie 1-amino-methyl-2,2-diarylcyclopropanecarboxamide

Also Published As

Publication number Publication date
CA1202639A (fr) 1986-04-01
EP0068999B1 (fr) 1985-05-22
EP0068999A1 (fr) 1983-01-05
ES8303293A1 (es) 1983-03-01
JPS6323186B2 (enExample) 1988-05-16
AU8508682A (en) 1983-01-06
US4478836A (en) 1984-10-23
FR2508035B1 (enExample) 1984-06-29
FR2508035A1 (fr) 1982-12-24
ATE13422T1 (de) 1985-06-15
AU550774B2 (en) 1986-04-10
JPS584752A (ja) 1983-01-11
LU90410I2 (fr) 1999-08-31
ZA824453B (en) 1983-04-27
ES512842A0 (es) 1983-03-01

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PIERRE FABRE S.A., BOULOGNE, FR

8328 Change in the person/name/address of the agent

Free format text: GRUENECKER, KINKELDEY, STOCKMAIR & SCHWANHAEUSSER, ANWALTSSOZIETAET, 80538 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: PIERRE FABRE MEDICAMENT, BOULOGNE, FR

8328 Change in the person/name/address of the agent

Free format text: W. SEEGER UND KOLLEGEN, 81369 MUENCHEN