FR2489148A2 - Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant - Google Patents
Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant Download PDFInfo
- Publication number
- FR2489148A2 FR2489148A2 FR8018994A FR8018994A FR2489148A2 FR 2489148 A2 FR2489148 A2 FR 2489148A2 FR 8018994 A FR8018994 A FR 8018994A FR 8018994 A FR8018994 A FR 8018994A FR 2489148 A2 FR2489148 A2 FR 2489148A2
- Authority
- FR
- France
- Prior art keywords
- alloxane
- alloxan
- reducing sugar
- stable
- solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 title claims abstract description 50
- 238000001914 filtration Methods 0.000 title claims abstract description 6
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 9
- 229960002737 fructose Drugs 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000012528 membrane Substances 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 239000008215 water for injection Substances 0.000 abstract description 2
- 230000000721 bacterilogical effect Effects 0.000 abstract 2
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 150000004685 tetrahydrates Chemical class 0.000 abstract 1
- 239000003708 ampul Substances 0.000 description 2
- ZIIHZVKHFWOENY-UHFFFAOYSA-N 5,5-dihydroxy-1,3-diazinane-2,4,6-trione Chemical compound OC1(O)C(=O)NC(=O)NC1=O ZIIHZVKHFWOENY-UHFFFAOYSA-N 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8018994A FR2489148A2 (fr) | 1979-06-15 | 1980-09-03 | Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7915363A FR2459046A1 (fr) | 1979-06-15 | 1979-06-15 | Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant |
| FR8018994A FR2489148A2 (fr) | 1979-06-15 | 1980-09-03 | Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2489148A2 true FR2489148A2 (fr) | 1982-03-05 |
| FR2489148B2 FR2489148B2 (enExample) | 1985-05-10 |
Family
ID=26221200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8018994A Granted FR2489148A2 (fr) | 1979-06-15 | 1980-09-03 | Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2489148A2 (enExample) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH227825A (fr) * | 1940-05-31 | 1943-07-15 | Parker Ste Continentale | Procédé d'usinage des métaux et alliages légers. |
| FR3743M (fr) * | 1963-06-06 | 1965-12-13 | Pierre Grobon | Soluté alloxanique sous azote cyto-stabilisant anti-cancéreux. application de la diabéto-thérapie alloxanique. |
| US3637640A (en) * | 1970-05-04 | 1972-01-25 | Diagnostic Data Inc | Orgotein stabilized with saccharide process and products |
| JPS496100A (enExample) * | 1972-05-10 | 1974-01-19 |
-
1980
- 1980-09-03 FR FR8018994A patent/FR2489148A2/fr active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH227825A (fr) * | 1940-05-31 | 1943-07-15 | Parker Ste Continentale | Procédé d'usinage des métaux et alliages légers. |
| FR3743M (fr) * | 1963-06-06 | 1965-12-13 | Pierre Grobon | Soluté alloxanique sous azote cyto-stabilisant anti-cancéreux. application de la diabéto-thérapie alloxanique. |
| US3637640A (en) * | 1970-05-04 | 1972-01-25 | Diagnostic Data Inc | Orgotein stabilized with saccharide process and products |
| JPS496100A (enExample) * | 1972-05-10 | 1974-01-19 |
Non-Patent Citations (5)
| Title |
|---|
| "Hagers Handbuch der Pharmazeutischen Praxis", vol. 7, partie A: Arzneiformen, 1971, Springer-Verlag, pages 372-373, Berlin (DE); * |
| CHEMICAL ABSTRACTS, vol. 51, no. 16, 25 août 1957, col. 13193e, Columbus Ohio (USA); * |
| CHEMICAL ABSTRACTS, vol. 82, no. 2, 13 janvier 1975, page 218, no. 7659y, Columbus Ohio (USA); & JP - A - 74 06 100 (SANKYO CO., LTD.) (12-02-1974) * |
| CHEMICAL ABSTRACTS, vol. 83, no. 20, 17 novembre 1975, page 268, no. 168380m, Columbus Ohio (USA); * |
| THE MERCK INDEX, édition 8, 1968, page 993, Merck & CO., Inc., Rahway, New Jersey (USA); * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2489148B2 (enExample) | 1985-05-10 |
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