FR2487072A1 - Perfectionnements aux systemes liquides de reference pour l'etalonnage et le controle de qualite d'analyseurs chimiques - Google Patents
Perfectionnements aux systemes liquides de reference pour l'etalonnage et le controle de qualite d'analyseurs chimiques Download PDFInfo
- Publication number
- FR2487072A1 FR2487072A1 FR8114203A FR8114203A FR2487072A1 FR 2487072 A1 FR2487072 A1 FR 2487072A1 FR 8114203 A FR8114203 A FR 8114203A FR 8114203 A FR8114203 A FR 8114203A FR 2487072 A1 FR2487072 A1 FR 2487072A1
- Authority
- FR
- France
- Prior art keywords
- calibration
- liquid
- solution
- concentration
- samples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 51
- 239000000126 substance Substances 0.000 title claims abstract description 9
- 238000003908 quality control method Methods 0.000 title description 3
- 230000000694 effects Effects 0.000 claims abstract description 33
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 239000011734 sodium Substances 0.000 claims description 39
- 239000012482 calibration solution Substances 0.000 claims description 37
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 34
- 229910052708 sodium Inorganic materials 0.000 claims description 32
- 239000000243 solution Substances 0.000 claims description 29
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 28
- 150000002500 ions Chemical class 0.000 claims description 28
- 239000011591 potassium Substances 0.000 claims description 28
- 229910052700 potassium Inorganic materials 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 18
- 239000012470 diluted sample Substances 0.000 claims description 11
- 239000003085 diluting agent Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 150000001450 anions Chemical class 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004313 potentiometry Methods 0.000 claims description 4
- 238000004040 coloring Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000005040 ion trap Methods 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 28
- 239000000523 sample Substances 0.000 description 24
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 20
- 210000004369 blood Anatomy 0.000 description 15
- 239000008280 blood Substances 0.000 description 15
- 210000002381 plasma Anatomy 0.000 description 15
- 239000011780 sodium chloride Substances 0.000 description 14
- 210000002700 urine Anatomy 0.000 description 13
- 239000001103 potassium chloride Substances 0.000 description 10
- 235000011164 potassium chloride Nutrition 0.000 description 10
- 239000003792 electrolyte Substances 0.000 description 8
- 239000011777 magnesium Substances 0.000 description 8
- 238000005048 flame photometry Methods 0.000 description 7
- 238000000093 extraction electrospray ionisation Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000000975 dye Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 4
- 235000011285 magnesium acetate Nutrition 0.000 description 4
- 239000011654 magnesium acetate Substances 0.000 description 4
- 229940069446 magnesium acetate Drugs 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000013060 biological fluid Substances 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229910001415 sodium ion Inorganic materials 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- -1 tetramethyl chloride Chemical compound 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- BNIVGPIKNKTNRO-UHFFFAOYSA-J C=O.C(C)(=O)[O-].[Mg+2].[Cl-].[K+].C(C)(=O)[O-].[Na+].[Cl-].[Na+] Chemical compound C=O.C(C)(=O)[O-].[Mg+2].[Cl-].[K+].C(C)(=O)[O-].[Na+].[Cl-].[Na+] BNIVGPIKNKTNRO-UHFFFAOYSA-J 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 235000019256 formaldehyde Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229910001414 potassium ion Inorganic materials 0.000 description 2
- 239000001044 red dye Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102100023795 Elafin Human genes 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 241000212342 Sium Species 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 101100269618 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) aliA gene Proteins 0.000 description 1
- 101100439746 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) cinA gene Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- NQMRYBIKMRVZLB-UHFFFAOYSA-N methylamine hydrochloride Chemical compound [Cl-].[NH3+]C NQMRYBIKMRVZLB-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 1
- BUKHSQBUKZIMLB-UHFFFAOYSA-L potassium;sodium;dichloride Chemical compound [Na+].[Cl-].[Cl-].[K+] BUKHSQBUKZIMLB-UHFFFAOYSA-L 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 238000005353 urine analysis Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000001043 yellow dye Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
- G01N27/4165—Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/492—Determining multiple analytes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17059980A | 1980-07-21 | 1980-07-21 | |
| US06/271,321 US4410631A (en) | 1980-07-21 | 1981-06-15 | Compensated reference liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2487072A1 true FR2487072A1 (fr) | 1982-01-22 |
| FR2487072B1 FR2487072B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-01-11 |
Family
ID=26866263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8114203A Granted FR2487072A1 (fr) | 1980-07-21 | 1981-07-21 | Perfectionnements aux systemes liquides de reference pour l'etalonnage et le controle de qualite d'analyseurs chimiques |
Country Status (7)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1174501B (it) * | 1984-02-28 | 1987-07-01 | Instrumentation Lab Spa | Metodo per la determinazione quantitativa del calcio nei liquidi biologici mediante potenziometria diretta |
| US5019238A (en) * | 1984-03-28 | 1991-05-28 | Baxter Diagnostics Inc. | Means for quantitative determination of analyte in liquids |
| US4627893A (en) * | 1984-03-28 | 1986-12-09 | Amdev, Inc. | Means and methods for quantitative determination of analyte in liquids |
| NL8500266A (nl) * | 1985-01-31 | 1986-08-18 | Stichting Gastransport | Ijkoplossing voor ion-selectieve elektroden, droog materiaal om het uit aan te maken, werkwijze voor het bereiden daarvan, en toepassing daarvan. |
| DK159837C (da) * | 1986-12-03 | 1991-04-29 | Radiometer As | Fremgangsmaade og apparat til afsloering af en proteinforurening paa en ph elektrode |
| JPH02112750A (ja) * | 1988-10-21 | 1990-04-25 | Hitachi Ltd | 血液ガス・イオン測定用電極の同時調整法およびその対照液 |
| JPH0789108B2 (ja) * | 1989-09-13 | 1995-09-27 | 株式会社日立製作所 | 電解質分析装置および電解質分析方法 |
| US5571396A (en) * | 1993-07-12 | 1996-11-05 | Dade International Inc. | Fluid analysis system and sensing electrode, electrode assembly, and sensing module components |
| WO2015191447A1 (en) * | 2014-06-12 | 2015-12-17 | Siemens Healthcare Diagnostics Inc. | Reagents for potentiometric magnesium ion selective electrode sensors and methods of production and use thereof |
| CN116888471A (zh) * | 2021-01-29 | 2023-10-13 | 雷迪奥米特医学公司 | 利用附加参考测量的电化学测量 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3556950A (en) * | 1966-07-15 | 1971-01-19 | Ibm | Method and apparatus for automatic electrochemical analysis |
| GB2030655A (en) * | 1978-09-07 | 1980-04-10 | Radiometer As | Method and an apparatus for transferring a reference liquid from an ampoule to an electrochemical measuring instrument |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283262A (en) * | 1980-07-01 | 1981-08-11 | Instrumentation Laboratory Inc. | Analysis system |
-
1981
- 1981-06-15 US US06/271,321 patent/US4410631A/en not_active Expired - Fee Related
- 1981-07-09 GB GB8121221A patent/GB2080543B/en not_active Expired
- 1981-07-16 AU AU73054/81A patent/AU548232B2/en not_active Ceased
- 1981-07-17 DE DE19813129029 patent/DE3129029A1/de not_active Withdrawn
- 1981-07-20 DK DK323081A patent/DK323081A/da not_active Application Discontinuation
- 1981-07-20 CA CA000382081A patent/CA1158966A/en not_active Expired
- 1981-07-21 FR FR8114203A patent/FR2487072A1/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3556950A (en) * | 1966-07-15 | 1971-01-19 | Ibm | Method and apparatus for automatic electrochemical analysis |
| GB2030655A (en) * | 1978-09-07 | 1980-04-10 | Radiometer As | Method and an apparatus for transferring a reference liquid from an ampoule to an electrochemical measuring instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| US4410631A (en) | 1983-10-18 |
| CA1158966A (en) | 1983-12-20 |
| GB2080543A (en) | 1982-02-03 |
| GB2080543B (en) | 1984-05-31 |
| AU7305481A (en) | 1982-01-28 |
| AU548232B2 (en) | 1985-12-05 |
| DE3129029A1 (de) | 1982-04-15 |
| FR2487072B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-01-11 |
| DK323081A (da) | 1982-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Dickson | The measurement of sea water pH | |
| Sommer et al. | Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing | |
| Work | Reaction of ninhydrin in acid solution with straight-chain amino acids containing two amino groups and its application to the estimation of α∈-diaminopimelic acid | |
| Fogh-Andersen et al. | Measurement of free calcium ion in capillary blood and serum. | |
| EP2449370B1 (fr) | Analyse et dosage d'hémoglobines glyquées par électrophorèse capillaire, compositions tampon et kits pour électrophorèse capillaire | |
| Kruskal et al. | Thyrotropin-releasing hormone-induced changes in intracellular [Ca2+] measured by microspectrofluorometry on individual quin2-loaded cells. | |
| US20040157275A1 (en) | Method for reducing effect of hematocrit on measurement of an analyte in whole blood, and test kit and test article useful in the method | |
| FR2487072A1 (fr) | Perfectionnements aux systemes liquides de reference pour l'etalonnage et le controle de qualite d'analyseurs chimiques | |
| Smith et al. | Copper determination in water by standard addition potentiometry | |
| Bargrizan et al. | Development of a spectrophotometric method for determining pH of soil extracts and comparison with glass electrode measurements | |
| Opitz et al. | New fluorescence photometrical techniques for simultaneous and continuous measurements of ionic strength and hydrogen ion activities | |
| Wang et al. | The effect of ouabain on intracellular activities of K+, Na+, Cl−, H+ and Ca2+ in proximal tubules of frog kidneys | |
| CA2720854C (en) | Hemoglobin based bilirubin reference material | |
| Yabu et al. | Measurement of iodide in urine using the iodide-selective ion electrode | |
| Patel et al. | A reagent-free phosphate chemiresistive sensor using carbon nanotubes functionalized with crystal violet | |
| US4487679A (en) | Potassium ion-selective electrode | |
| Band et al. | Relationship between activity and concentration measurements of plasma potassium | |
| Kwak et al. | The binding of divalent metal ions to polyelectrolytes in mixed counterion systems: I. The dye spectrophotometric method | |
| Sundberg et al. | An enzymic creatinine assay and a direct ammonia assay in coated thin films. | |
| US20050142503A1 (en) | Concentrated azo dye solution, a staining kit comprising it, and a method for preparing a protein staining solution | |
| US20030068822A1 (en) | Hemoglobin assay calibration and control | |
| JPH0219769A (ja) | Ｐｈ分析器及び電解質を標準化するための緩衝溶液系 | |
| CH615510A5 (en) | Chemical analysis process and product for implementing this process | |
| Meier et al. | Applicability of available ion-selective liquid-membrane microelectrodes to intracellular ion-activity measurements | |
| US5227305A (en) | Buffer solution systems for standardizing pH analyzers and electrolytes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| ST | Notification of lapse |