FR2465743A1 - Nouveaux derives 2-substitues de desoxy-2 fortimicines a et b, utiles notamment comme medicaments antibiotiques, et intermediaires et procede de leur preparation - Google Patents

Nouveaux derives 2-substitues de desoxy-2 fortimicines a et b, utiles notamment comme medicaments antibiotiques, et intermediaires et procede de leur preparation Download PDF

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Publication number
FR2465743A1
FR2465743A1 FR8020601A FR8020601A FR2465743A1 FR 2465743 A1 FR2465743 A1 FR 2465743A1 FR 8020601 A FR8020601 A FR 8020601A FR 8020601 A FR8020601 A FR 8020601A FR 2465743 A1 FR2465743 A1 FR 2465743A1
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FR
France
Prior art keywords
fortimicin
deoxy
methanol
benzyloxycarbonyl
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8020601A
Other languages
English (en)
French (fr)
Other versions
FR2465743B1 (enExample
Inventor
Jerry Roy Martin
John Soloman Tadanier
Paulette Johnson
Alex Michael Nadzan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of FR2465743A1 publication Critical patent/FR2465743A1/fr
Application granted granted Critical
Publication of FR2465743B1 publication Critical patent/FR2465743B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8020601A 1979-09-26 1980-09-25 Nouveaux derives 2-substitues de desoxy-2 fortimicines a et b, utiles notamment comme medicaments antibiotiques, et intermediaires et procede de leur preparation Granted FR2465743A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/079,145 US4250304A (en) 1979-09-26 1979-09-26 2-Deoxy-2-substituted fortimicin A and B and derivatives

Publications (2)

Publication Number Publication Date
FR2465743A1 true FR2465743A1 (fr) 1981-03-27
FR2465743B1 FR2465743B1 (enExample) 1983-07-08

Family

ID=22148726

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8020601A Granted FR2465743A1 (fr) 1979-09-26 1980-09-25 Nouveaux derives 2-substitues de desoxy-2 fortimicines a et b, utiles notamment comme medicaments antibiotiques, et intermediaires et procede de leur preparation

Country Status (10)

Country Link
US (1) US4250304A (enExample)
JP (1) JPS5657799A (enExample)
AR (1) AR226437A1 (enExample)
AU (1) AU6199180A (enExample)
BE (1) BE885402A (enExample)
DE (1) DE3036185A1 (enExample)
ES (1) ES8200119A1 (enExample)
FR (1) FR2465743A1 (enExample)
GB (1) GB2059958A (enExample)
GR (1) GR70198B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5659792A (en) * 1979-10-23 1981-05-23 Kyowa Hakko Kogyo Co Ltd Fortimicin derivative and its preparation
JPS5721399A (en) * 1980-07-12 1982-02-04 Kyowa Hakko Kogyo Co Ltd Fortimicin a derivative and its preparation
JPS5740496A (en) * 1980-08-22 1982-03-06 Microbial Chem Res Found Low toxic derivative of istamycin antibiotic
JPS58128395A (ja) * 1982-01-27 1983-07-30 Microbial Chem Res Found ３−０−デメチルイスタマイシンｂの低毒性誘導体
GB2118179A (en) * 1982-04-09 1983-10-26 Abbott Lab 2-Deoxy-3- demethoxyfortimicin A and B and related compounds
JPS6042394A (ja) * 1983-08-18 1985-03-06 Kowa Co 新規なアミノグリコシド及びその製法
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2010838A (en) * 1977-12-21 1979-07-04 Abbott Lab 2-deoxyfortimicin b and intermediates therefor
GB2010810A (en) * 1977-12-21 1979-07-04 Abbott Lab 2-deoxyfortimicin a4-n alkyl and 4-n-alcyl-2-deoxyfortimicin b derivatives and intermediates thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176178A (en) * 1977-12-21 1979-11-27 Abbott Laboratories 2-Deoxy-2'-N-acyl and alkyl fortimicins A and B

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2010838A (en) * 1977-12-21 1979-07-04 Abbott Lab 2-deoxyfortimicin b and intermediates therefor
GB2010810A (en) * 1977-12-21 1979-07-04 Abbott Lab 2-deoxyfortimicin a4-n alkyl and 4-n-alcyl-2-deoxyfortimicin b derivatives and intermediates thereof

Also Published As

Publication number Publication date
ES495313A0 (es) 1981-10-16
BE885402A (fr) 1981-03-25
FR2465743B1 (enExample) 1983-07-08
GB2059958A (en) 1981-04-29
US4250304A (en) 1981-02-10
ES8200119A1 (es) 1981-10-16
GR70198B (enExample) 1982-08-31
AR226437A1 (es) 1982-07-15
JPS5657799A (en) 1981-05-20
AU6199180A (en) 1981-04-02
DE3036185A1 (de) 1981-04-16

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