FR2462421A1 - Procede de preparation du sel d'acide p-acetamidobenzoique d'un complexe inosine-dimethylaminoisopropanol - Google Patents
Procede de preparation du sel d'acide p-acetamidobenzoique d'un complexe inosine-dimethylaminoisopropanol Download PDFInfo
- Publication number
- FR2462421A1 FR2462421A1 FR7919879A FR7919879A FR2462421A1 FR 2462421 A1 FR2462421 A1 FR 2462421A1 FR 7919879 A FR7919879 A FR 7919879A FR 7919879 A FR7919879 A FR 7919879A FR 2462421 A1 FR2462421 A1 FR 2462421A1
- Authority
- FR
- France
- Prior art keywords
- inosine
- prepn
- water
- complex salt
- pharmacological activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 title claims abstract description 10
- 229930010555 Inosine Natural products 0.000 title claims abstract description 10
- 229960003786 inosine Drugs 0.000 title claims abstract description 10
- 150000003839 salts Chemical class 0.000 title claims abstract description 8
- QCXJEYYXVJIFCE-UHFFFAOYSA-N 4-acetamidobenzoic acid Chemical compound CC(=O)NC1=CC=C(C(O)=O)C=C1 QCXJEYYXVJIFCE-UHFFFAOYSA-N 0.000 title abstract description 3
- 230000000144 pharmacologic effect Effects 0.000 title abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 11
- POIVWEXWFKSJHL-UHFFFAOYSA-N 2-(dimethylamino)propan-2-ol Chemical compound CN(C)C(C)(C)O POIVWEXWFKSJHL-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003960 organic solvent Substances 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 4
- 238000009835 boiling Methods 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical group CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical group COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims 2
- 239000011877 solvent mixture Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 abstract description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- -1 Aliphatic alcohols Chemical class 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7919879A FR2462421A1 (fr) | 1979-08-02 | 1979-08-02 | Procede de preparation du sel d'acide p-acetamidobenzoique d'un complexe inosine-dimethylaminoisopropanol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7919879A FR2462421A1 (fr) | 1979-08-02 | 1979-08-02 | Procede de preparation du sel d'acide p-acetamidobenzoique d'un complexe inosine-dimethylaminoisopropanol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2462421A1 true FR2462421A1 (fr) | 1981-02-13 |
| FR2462421B3 FR2462421B3 (OSRAM) | 1982-07-02 |
Family
ID=9228561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7919879A Granted FR2462421A1 (fr) | 1979-08-02 | 1979-08-02 | Procede de preparation du sel d'acide p-acetamidobenzoique d'un complexe inosine-dimethylaminoisopropanol |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2462421A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666891A (en) * | 1984-02-08 | 1987-05-19 | Newport Ag | Method of stimulating animal growth by administering feed and inosine complex |
-
1979
- 1979-08-02 FR FR7919879A patent/FR2462421A1/fr active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666891A (en) * | 1984-02-08 | 1987-05-19 | Newport Ag | Method of stimulating animal growth by administering feed and inosine complex |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2462421B3 (OSRAM) | 1982-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |