FR2458540A1 - Nouveaux derives de l'encephaline, procede de preparation de ces derives et medicaments les contenant - Google Patents

Nouveaux derives de l'encephaline, procede de preparation de ces derives et medicaments les contenant Download PDF

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Publication number
FR2458540A1
FR2458540A1 FR8012496A FR8012496A FR2458540A1 FR 2458540 A1 FR2458540 A1 FR 2458540A1 FR 8012496 A FR8012496 A FR 8012496A FR 8012496 A FR8012496 A FR 8012496A FR 2458540 A1 FR2458540 A1 FR 2458540A1
Authority
FR
France
Prior art keywords
amide
group
enkephalin
derivatives
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8012496A
Other languages
English (en)
French (fr)
Other versions
FR2458540B1 (de
Inventor
Sandor Bajusz
Andras Ronay
Jozsef Szekely
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of FR2458540A1 publication Critical patent/FR2458540A1/fr
Application granted granted Critical
Publication of FR2458540B1 publication Critical patent/FR2458540B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR8012496A 1979-06-12 1980-06-05 Nouveaux derives de l'encephaline, procede de preparation de ces derives et medicaments les contenant Granted FR2458540A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79GO1448A HU178004B (en) 1979-06-12 1979-06-12 Process for preparing new encephaline derivatives

Publications (2)

Publication Number Publication Date
FR2458540A1 true FR2458540A1 (fr) 1981-01-02
FR2458540B1 FR2458540B1 (de) 1984-04-27

Family

ID=10996895

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8012496A Granted FR2458540A1 (fr) 1979-06-12 1980-06-05 Nouveaux derives de l'encephaline, procede de preparation de ces derives et medicaments les contenant

Country Status (8)

Country Link
JP (1) JPS56115752A (de)
BE (1) BE883641A (de)
CH (1) CH645093A5 (de)
DE (1) DE3022098A1 (de)
FR (1) FR2458540A1 (de)
GB (1) GB2053925B (de)
HU (1) HU178004B (de)
NL (1) NL8003423A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085963B1 (de) * 1982-02-05 1987-01-21 The Wellcome Foundation Limited Pharmazeutische Verbindungen, deren Herstellung, Anwendung, deren Zwischenverbindungen und Herstellung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts vol. 83, no. 13, 29 septembre 1975, Columbus, Ohio, USA G. WEITZEL et al. "Structure and activity of insulin. XIII. Specificity of the arginine-guanidino group in biologically active tetrapeptides of the insulin sequence B 22-25 (Arg-Gly-Phe-Phe) *
Chemical Abstracts vol. 84, no. 11, 15 mars 1976 Columbus, Ohio, USA K. EISELE et al. "Synthesis of homoarginine and a homoarginyl tetrapeptide amide" page 488, colonne 2, abrégé no. 74606h, en combi naison avec C.A. Chemical subject index 1972-76, p *
Chemical Abstracts vol. 92, no. 17, 28 avril 1980 Columbus, Ohio, USA S. BAJUSZ et al. "Further enhancement of analgesic activity: enkephalin analogs with terminal guanidino group" page 71, colonne 1, abrégé no. 140894u *

Also Published As

Publication number Publication date
CH645093A5 (de) 1984-09-14
FR2458540B1 (de) 1984-04-27
NL8003423A (nl) 1980-12-16
GB2053925A (en) 1981-02-11
JPS56115752A (en) 1981-09-11
DE3022098A1 (de) 1980-12-18
BE883641A (fr) 1980-12-05
HU178004B (en) 1982-02-28
GB2053925B (en) 1983-04-07

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