FR2453155A1 - Derives de cyanoguanidine, leur procede de preparation et leurs applications en therapeutique - Google Patents

Derives de cyanoguanidine, leur procede de preparation et leurs applications en therapeutique

Info

Publication number
FR2453155A1
FR2453155A1 FR8003470A FR8003470A FR2453155A1 FR 2453155 A1 FR2453155 A1 FR 2453155A1 FR 8003470 A FR8003470 A FR 8003470A FR 8003470 A FR8003470 A FR 8003470A FR 2453155 A1 FR2453155 A1 FR 2453155A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic applications
cyanoguanidine derivatives
cyanoguanidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8003470A
Other languages
English (en)
French (fr)
Other versions
FR2453155B1 (enExample
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP54015990A external-priority patent/JPS6016940B2/ja
Priority claimed from JP1598979A external-priority patent/JPS568357A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of FR2453155A1 publication Critical patent/FR2453155A1/fr
Application granted granted Critical
Publication of FR2453155B1 publication Critical patent/FR2453155B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8003470A 1979-02-16 1980-02-18 Derives de cyanoguanidine, leur procede de preparation et leurs applications en therapeutique Granted FR2453155A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP54015990A JPS6016940B2 (ja) 1979-02-16 1979-02-16 シアノグアニジン誘導体およびその製造法
JP1598979A JPS568357A (en) 1979-02-16 1979-02-16 Cyanoguanidine derivative and its production

Publications (2)

Publication Number Publication Date
FR2453155A1 true FR2453155A1 (fr) 1980-10-31
FR2453155B1 FR2453155B1 (enExample) 1983-07-08

Family

ID=26352224

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8003470A Granted FR2453155A1 (fr) 1979-02-16 1980-02-18 Derives de cyanoguanidine, leur procede de preparation et leurs applications en therapeutique

Country Status (9)

Country Link
US (5) US4287346A (enExample)
CA (1) CA1145751A (enExample)
CH (1) CH641772A5 (enExample)
DE (1) DE3005786A1 (enExample)
FR (1) FR2453155A1 (enExample)
GB (2) GB2107306B (enExample)
IT (1) IT1141214B (enExample)
NL (1) NL8000869A (enExample)
SE (2) SE8001216L (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310313A3 (en) * 1987-09-28 1990-09-26 Smith Kline & French Laboratories Limited Anti-arrhythmic agent

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287346A (en) * 1979-02-16 1981-09-01 Eisai Co., Ltd. Cyanoguanidine derivatives
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
IE54196B1 (en) * 1981-09-10 1989-07-19 Leo Pharm Prod Ltd Chemical compounds
IT1190793B (it) * 1982-04-27 1988-02-24 Magis Farmaceutici Composti attivi nel trattamento dell'ulcera e sintomi allergici della pelle
US4496573A (en) * 1982-08-24 1985-01-29 William H. Rorer, Inc. 1-Pyridylmethyl-3-acyl guanidines
US4529723A (en) * 1983-04-29 1985-07-16 William H. Rorer, Inc. Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
US4689348A (en) * 1984-08-17 1987-08-25 Dow Chemical Company Cyanoguanidines useful as animal growth promoting agents
US4661520A (en) * 1984-08-17 1987-04-28 The Dow Chemical Company Cyanoguanidine useful as an animal growth promoting agent
FR2579201B1 (fr) * 1985-03-19 1987-05-07 Bernard Lyon I Universite Clau Composes chimiques perfectionnes, utilisation comme agents edulcorants et compositions contenant de tels agents
US4921939A (en) * 1985-03-19 1990-05-01 Universite Claude Bernard -Lyon 1 Sweetening agents
FR2579202B1 (fr) * 1985-03-19 1988-04-29 Univ Claude Bernard Lyon Nouveaux composes chimiques, utilisation comme agents edulcorants et compositions contenant de tels agents
US4963573A (en) * 1985-11-04 1990-10-16 Janssen Pharmaceutica N.V. [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters
US4746671A (en) * 1985-11-04 1988-05-24 Janssen Pharmaceutica N.V. Pharmaceutical use of [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters
US4895840A (en) * 1987-06-10 1990-01-23 A. H. Robins Company, Incorporated N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
US4900740A (en) * 1987-10-02 1990-02-13 The Nutrasweet Company N,N'-disubstituted guanidines containing a carboxyl or a tetrazolyl moiety
FR2624699B1 (fr) * 1987-12-18 1990-04-13 Bernard Lyon I Universite Clau Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-glycine ou beta-alanine utiles comme agents edulcorants
US5272164A (en) * 1988-12-27 1993-12-21 Kirin Beer Kabushiki Kaisha Carboximidamide derivatives
FI95244C (fi) * 1988-12-27 1996-01-10 Kirin Brewery Analogiamenetelmä valmistaa lääkeaineina käyttökelpoisia uusia karboksimidiamidijohdannaisia tai niiden farmaseuttisesti sopivia happoadditiosuoloja
JPH0662567B2 (ja) * 1988-12-27 1994-08-17 麒麟麦酒株式会社 ピリジンカルボキシイミダミド誘導体、その製造中間体、製造法および用途
IE911168A1 (en) * 1990-04-13 1991-10-23 Takeda Chemical Industries Ltd Novel intermediates for preparing guanidine derivatives,¹their preparation and use
WO1994004499A1 (en) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines as potassium channel blockers
AU673785B2 (en) * 1993-06-11 1996-11-21 Upjohn Company, The Pyrimidine cyanoguanidines as K-channel blockers
US6022984A (en) * 1998-07-27 2000-02-08 Pfizer Inc. Efficient synthesis of furan sulfonamide compounds useful in the synthesis of new IL-1 inhibitors
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3028391A (en) * 1960-03-30 1962-04-03 Searle & Co 1-alkyl-3-(alpha-phenyl-4-pyridylmethyl) ureas and thioureas
US3128280A (en) * 1959-10-23 1964-04-07 Searle & Co 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas
FR2199467A2 (enExample) * 1972-09-05 1974-04-12 Smith Kline French Lab
FR2229417A1 (enExample) * 1973-05-17 1974-12-13 Smith Kline French Lab
FR2319343A1 (fr) * 1975-07-31 1977-02-25 Smith Kline French Lab Nouvelles guanidines, leur procede de preparation et leur application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156727A (en) * 1975-07-31 1979-05-29 Smith Kline & French Laboratories Limited Alkoxy pyridine compounds
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
US4287346A (en) * 1979-02-16 1981-09-01 Eisai Co., Ltd. Cyanoguanidine derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128280A (en) * 1959-10-23 1964-04-07 Searle & Co 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas
US3028391A (en) * 1960-03-30 1962-04-03 Searle & Co 1-alkyl-3-(alpha-phenyl-4-pyridylmethyl) ureas and thioureas
FR2199467A2 (enExample) * 1972-09-05 1974-04-12 Smith Kline French Lab
FR2229417A1 (enExample) * 1973-05-17 1974-12-13 Smith Kline French Lab
FR2319343A1 (fr) * 1975-07-31 1977-02-25 Smith Kline French Lab Nouvelles guanidines, leur procede de preparation et leur application

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310313A3 (en) * 1987-09-28 1990-09-26 Smith Kline & French Laboratories Limited Anti-arrhythmic agent

Also Published As

Publication number Publication date
US4426521A (en) 1984-01-17
IT1141214B (it) 1986-10-01
FR2453155B1 (enExample) 1983-07-08
CA1145751A (en) 1983-05-03
CH641772A5 (de) 1984-03-15
GB2046736B (en) 1983-05-18
SE8403871D0 (sv) 1984-07-26
DE3005786A1 (de) 1980-08-28
SE8403871L (sv) 1984-07-26
US4327217A (en) 1982-04-27
SE8001216L (sv) 1980-08-17
US4287346A (en) 1981-09-01
IT8019938A0 (it) 1980-02-15
GB2107306A (en) 1983-04-27
US4363921A (en) 1982-12-14
GB2046736A (en) 1980-11-19
US4396764A (en) 1983-08-02
GB2107306B (en) 1983-09-01
NL8000869A (nl) 1980-08-19

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