FR2451910A1 - Nouveaux derives amino-alcools, leurs procedes de preparation, et compositions pharmaceutiques renfermant ces produits - Google Patents

Nouveaux derives amino-alcools, leurs procedes de preparation, et compositions pharmaceutiques renfermant ces produits

Info

Publication number
FR2451910A1
FR2451910A1 FR8006169A FR8006169A FR2451910A1 FR 2451910 A1 FR2451910 A1 FR 2451910A1 FR 8006169 A FR8006169 A FR 8006169A FR 8006169 A FR8006169 A FR 8006169A FR 2451910 A1 FR2451910 A1 FR 2451910A1
Authority
FR
France
Prior art keywords
bopi
formula
products
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8006169A
Other languages
English (en)
Other versions
FR2451910B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of FR2451910A1 publication Critical patent/FR2451910A1/fr
Application granted granted Critical
Publication of FR2451910B1 publication Critical patent/FR2451910B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

NOUVEAUX DERIVES AMINO-ALCOOLS, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES RENFERMANT CES PRODUITS. LES NOUVEAUX AMINO-ALCOOLS CORRESPONDANT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE: (CF DESSIN DANS BOPI) ET R ET R IDENTIQUES OU DIFFERENTS REPRESENTENT CHACUN H OU CH; R REPRESENTE UN GROUPE SUBSTITUE, PHENYLE, PHENOXYMETHYLE, HETEROCYCLIQUE OU HETEROCYCLO-OXYMETHYLE, ET Y REPRESENTE H OU UN GROUPE PROTEGEANT LE GROUPE AMINO, SONT PREPARES EN FAISANT REAGIR SOUS REFLUX DANS UN SOLVANT ORGANIQUE, SOIT UN COMPOSE DE FORMULE: (CF DESSIN DANS BOPI) AVEC UN COMPOSE DE FORMULE: (CF DESSIN DANS BOPI) SOIT UN COMPOSE DE FORMULE: (CF DESSIN DANS BOPI) OU X REPRESENTE UN ATOME D'HALOGENE AVEC UN COMPOSE DE FORMULE: (CF DESSIN DANS BOPI) ET DANS CE DERNIER CAS, EN REDUISANT LE COMPOSE OBTENU. UTILISATION DE CES COMPOSES COMME MEDICAMENTS POUR MALADIES CARDIOVASCULAIRES ET CEREBROVASCULAIRES.
FR8006169A 1979-03-20 1980-03-19 Nouveaux derives amino-alcools, leurs procedes de preparation, et compositions pharmaceutiques renfermant ces produits Expired FR2451910B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3175079A JPS55124742A (en) 1979-03-20 1979-03-20 Novel aminoalcohol derivative

Publications (2)

Publication Number Publication Date
FR2451910A1 true FR2451910A1 (fr) 1980-10-17
FR2451910B1 FR2451910B1 (fr) 1987-02-06

Family

ID=12339690

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8006169A Expired FR2451910B1 (fr) 1979-03-20 1980-03-19 Nouveaux derives amino-alcools, leurs procedes de preparation, et compositions pharmaceutiques renfermant ces produits

Country Status (6)

Country Link
US (2) US4381398A (fr)
JP (1) JPS55124742A (fr)
CH (1) CH643809A5 (fr)
DE (1) DE3010752A1 (fr)
FR (1) FR2451910B1 (fr)
GB (1) GB2046259B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206125A (en) * 1979-05-04 1980-06-03 Richardson-Merrell Inc. 5-[2-[(2,3-Dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydroxyethyl]-2-hydroxybenzoic acid derivatives
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4593119A (en) * 1980-11-28 1986-06-03 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
GB8618324D0 (en) * 1986-07-28 1986-09-03 Shell Int Research Phenylacetate/atenolol
US5160453A (en) 1989-02-21 1992-11-03 Westvaco Corporation Cationic aqueous bituminous emulsion-aggregate slurries
NZ267830A (en) 1993-06-25 1998-05-27 Merrell Pharma Inc Preparation of 4-diphenylmethyl or 4-diphenylmethoxy piperidine derivatives and intermediates therefor
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
FR2746395B1 (fr) * 1996-03-22 1998-04-17 Adir Nouveaux derives d'arylethanolamine et d'aryloxypropanolamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AUPO565997A0 (en) * 1997-03-17 1997-04-10 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
US6689898B2 (en) 1998-07-02 2004-02-10 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
IL153594A0 (en) * 2000-07-13 2003-07-06 Sankyo Co Amino alcohol derivatives and pharmaceutical compositions containing the same
WO2002072567A2 (fr) * 2001-03-13 2002-09-19 Glenmark Pharmaceuticals Limited Nouveaux composes heterocycliques utiles dans le traitement des troubles allergiques inflammatoires; procede de leur preparation et compositions pharmaceutiques les contenant
AU2003298094A1 (en) * 2002-10-22 2004-05-13 Glaxo Group Limited Medicinal arylethanolamine compounds
EP1619292A2 (fr) 2004-07-22 2006-01-25 Sparrow International, Inc. Composition antimicrobienne de chitosan pour des produits textile

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007294A2 (fr) * 1978-06-30 1980-01-23 Aktiebolaget Hässle Composés stabilisateurs de membranes avec activité de blocage de récepteurs bêta, leur préparation, méthode de traitement des conditions arythmiques et compositions pharmaceutiques les contenant

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054104A (fr) * 1962-07-20
GB1038333A (en) * 1963-02-13 1966-08-10 Ici Ltd Pharmaceutical compositions
DE1543372A1 (de) * 1966-10-18 1971-04-01 Boehringer Sohn Ingelheim Verfahren zur Herstellung von o-substituierten 3,4-Dioxyphenylalkanolaminen
GB1245148A (en) 1968-11-18 1971-09-08 Pfizer Ltd Propanolamine derivatives
GB1247370A (en) 1968-12-31 1971-09-22 Allen & Hanburys Ltd Glyoxals and production thereof
GB1266058A (fr) 1969-07-08 1972-03-08
FR2119843B1 (fr) * 1970-12-28 1974-03-22 Laroche Navarro Labo
US3883560A (en) * 1973-07-05 1975-05-13 Colgate Palmolive Co Salicylamidophenethanolamines
CH592625A5 (fr) 1974-05-14 1977-10-31 Ciba Geigy Ag
US4165384A (en) * 1974-11-01 1979-08-21 Aktiebolaget Hassle Amide substituted phenoxy propanol amines
SE7604448L (sv) 1975-04-17 1976-10-18 Scherico Ltd Diastereoisomerer av fenylaminoetanol-derivat
GB1529972A (en) 1975-07-29 1978-10-25 Allen & Hanburys Ltd Basic alcohols
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
US4263325A (en) * 1977-10-05 1981-04-21 Aktiebolaget Hassle β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
CA1147342A (fr) * 1977-10-12 1983-05-31 Kazuo Imai Procede de preparation de nouveaux derives de la phenylethanolamine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007294A2 (fr) * 1978-06-30 1980-01-23 Aktiebolaget Hässle Composés stabilisateurs de membranes avec activité de blocage de récepteurs bêta, leur préparation, méthode de traitement des conditions arythmiques et compositions pharmaceutiques les contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/73 *

Also Published As

Publication number Publication date
JPS55124742A (en) 1980-09-26
CH643809A5 (de) 1984-06-29
FR2451910B1 (fr) 1987-02-06
GB2046259A (en) 1980-11-12
DE3010752A1 (de) 1980-10-02
US4450115A (en) 1984-05-22
JPS6215062B2 (fr) 1987-04-06
US4381398A (en) 1983-04-26
GB2046259B (en) 1983-07-20

Similar Documents

Publication Publication Date Title
FR2451910A1 (fr) Nouveaux derives amino-alcools, leurs procedes de preparation, et compositions pharmaceutiques renfermant ces produits
FI896300A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 1,4-disubstituoitujen piperatsiinijohdannaisten valmistamiseksi
DE3873612D1 (de) Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
HUP9903018A2 (hu) Pirazolopiridilpiridazinon-származékok és eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
FR2416888A1 (fr) Nouveaux derives de phenyl-piperazine utiles comme medicaments
FR2397403A1 (fr) Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes
ES478605A1 (es) Un procedimiento para preparar derivados de flavano.
ES8704917A1 (es) Procedimiento para prepararar derivados de 1-piperazinacarboximida.
DE3767351D1 (de) Sialosylceramide und verfahren zu deren herstellung.
FR2414044A1 (fr) Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments
FR2392999A1 (fr) Nouveaux derives de l'acide 6-((aminosulfonyl)-phenyl)-1,2-dihydro-2-oxonicotinique utile comme medicament
HUT50337A (en) Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
ATE18226T1 (de) Pyrrolo(2,3-d)carbazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
IL61687A (en) (benzothiazole-2-yl-thio)-phenylpropionic acid derivatives,pharmaceutical formulations containing them and a process for their preparation
EP0049565A3 (fr) Dérivés de N-alkylimidazoles substitués, leur préparation et compositions pharmaceutiques les contenant
ES8701174A1 (es) Un metodo de preparacion de un compuesto de tiadiazina
ATE35133T1 (de) N-substituierte (bis(hydroxymethyl)-methyl>isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
DK152053C (da) Analogifremgangsmaade til fremstilling af anthracyclinglycosider eller deres farmaceutiske acceptable syreadditionssalte
ATE59637T1 (de) Neue basisch substituierte pyridinverbindungen, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung.
ZA796386B (en) New process for preparing derivatives of piperidyl-indole,new compound obtained and its salts,their use as medicaments and the pharmaceutical compositions containing them
ATE34740T1 (de) (bis(hydroxymethyl)methyl)-isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
ATE36321T1 (de) (bis(substituiertes methyl)methyl>isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
DK527483A (da) Fremgangsmaade til fremstilling af benzazepinderivater
ATE36154T1 (de) 4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Legal Events

Date Code Title Description
ST Notification of lapse