FR2431488A1 - Procede pour la preparation du 2,6-dimethyl-4-(3-nitrophenyl)-3-methoxycarbonyl - 1,4-dihydropyridine-5-carboxylate de 2-(n-benzyl-n-methylamino) ethyle - Google Patents
Procede pour la preparation du 2,6-dimethyl-4-(3-nitrophenyl)-3-methoxycarbonyl - 1,4-dihydropyridine-5-carboxylate de 2-(n-benzyl-n-methylamino) ethyleInfo
- Publication number
- FR2431488A1 FR2431488A1 FR7917473A FR7917473A FR2431488A1 FR 2431488 A1 FR2431488 A1 FR 2431488A1 FR 7917473 A FR7917473 A FR 7917473A FR 7917473 A FR7917473 A FR 7917473A FR 2431488 A1 FR2431488 A1 FR 2431488A1
- Authority
- FR
- France
- Prior art keywords
- nitrophenyl
- dimethyl
- methylamino
- benzyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
a. Procédé pour la préparation du 2,6-diméthyl-4-(3-nitrophényl)-3-méthoxycarbonyl-1,4-dihydropyridine-5-carboxylate de 2-(N-benzyl-N-méthylamino)éthyle. b. Le composé selon l'invention est obtenu par une réaction de transestérification en faisant réagir l'ester diméthylique de l'acide 2,6-diméthyl-4-(3-nitrophényl)-1,4-dihydropyridine-3,5-dicarboxylique (VII) avec la N-(2-hydroxy-éthyl)-N-méthyl-benzylamine (VIII) dans un solvant et en presence d'un catalyseur, et en séparant ensuite du mélange de réaction, le réactif VII non converti, le produit selon l'invention et le sous-produit constitué par l'ester bis-Ø2-(N-benzyl-N-méthylamino)éthyliqueõ de l'acide 2,6-diméthyl-4-(3-nitrophényl)-1,4-dihydropyridine-3,5-dicarboxylique (IX). c. Le composé selon l'invention est un médicament utile comme vasodilatateur.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT25791/78A IT1097538B (it) | 1978-07-17 | 1978-07-17 | Processo per la preparazione del 2,6-dimetil-4-3(3-nitrofenil)-3-metossicarbonil-1,4-didropiridin-5-carbossilati di 2(n-benzil-n-metilammino) |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2431488A1 true FR2431488A1 (fr) | 1980-02-15 |
FR2431488B1 FR2431488B1 (fr) | 1983-05-27 |
Family
ID=11217752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7917473A Granted FR2431488A1 (fr) | 1978-07-17 | 1979-07-05 | Procede pour la preparation du 2,6-dimethyl-4-(3-nitrophenyl)-3-methoxycarbonyl - 1,4-dihydropyridine-5-carboxylate de 2-(n-benzyl-n-methylamino) ethyle |
Country Status (6)
Country | Link |
---|---|
AR (1) | AR218549A1 (fr) |
BE (1) | BE877311A (fr) |
DE (1) | DE2928022C2 (fr) |
ES (1) | ES475976A1 (fr) |
FR (1) | FR2431488A1 (fr) |
IT (1) | IT1097538B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2532648A1 (fr) * | 1982-09-03 | 1984-03-09 | Otsuka Pharma Co Ltd | Derives de carbostyrile, leur procede de preparation et leur application en therapeutique |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61212561A (ja) * | 1985-03-16 | 1986-09-20 | Toyo Pharma- Kk | 1,4−ジヒドロピリジン誘導体の製造方法 |
ES2332168B1 (es) * | 2008-04-30 | 2010-10-27 | Consejo Superior De Investigaciones Cientificas (Csic) (75%) | Forma pseudopolimorfica de hidrocloruro de nicardipina, procedimiento para su preparacion y formulacion que la contiene. |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2218107A1 (en) * | 1973-02-20 | 1974-09-13 | Yamanouchi Pharma Co Ltd | Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents |
JPS50101365A (fr) * | 1974-01-21 | 1975-08-11 | ||
JPS50131972A (fr) * | 1974-04-10 | 1975-10-18 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1430961A (en) * | 1972-01-22 | 1976-04-07 | Yamanouchi Pharma Co Ltd | 1-substituted-1,4-dihyddrypyridine derivatives |
GB1455502A (en) * | 1973-02-20 | 1976-11-10 | Yamanouchi Pharma Co Ltd | 1,4-dihydropyridine derivatives |
-
1978
- 1978-07-17 IT IT25791/78A patent/IT1097538B/it active
- 1978-12-13 ES ES475976A patent/ES475976A1/es not_active Expired
-
1979
- 1979-06-27 BE BE0/195999A patent/BE877311A/fr not_active IP Right Cessation
- 1979-07-05 FR FR7917473A patent/FR2431488A1/fr active Granted
- 1979-07-05 AR AR277193A patent/AR218549A1/es active
- 1979-07-11 DE DE2928022A patent/DE2928022C2/de not_active Expired
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2218107A1 (en) * | 1973-02-20 | 1974-09-13 | Yamanouchi Pharma Co Ltd | Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents |
JPS50101365A (fr) * | 1974-01-21 | 1975-08-11 | ||
JPS50131972A (fr) * | 1974-04-10 | 1975-10-18 |
Non-Patent Citations (1)
Title |
---|
CA1976 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2532648A1 (fr) * | 1982-09-03 | 1984-03-09 | Otsuka Pharma Co Ltd | Derives de carbostyrile, leur procede de preparation et leur application en therapeutique |
Also Published As
Publication number | Publication date |
---|---|
IT1097538B (it) | 1985-08-31 |
AR218549A1 (es) | 1980-06-13 |
DE2928022A1 (de) | 1980-01-31 |
IT7825791A0 (it) | 1978-07-17 |
BE877311A (fr) | 1979-10-15 |
ES475976A1 (es) | 1979-04-16 |
DE2928022C2 (de) | 1986-11-27 |
FR2431488B1 (fr) | 1983-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |