FR2218107A1 - Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents - Google Patents

Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents

Info

Publication number
FR2218107A1
FR2218107A1 FR7405678A FR7405678A FR2218107A1 FR 2218107 A1 FR2218107 A1 FR 2218107A1 FR 7405678 A FR7405678 A FR 7405678A FR 7405678 A FR7405678 A FR 7405678A FR 2218107 A1 FR2218107 A1 FR 2218107A1
Authority
FR
France
Prior art keywords
alkyl
dihydropyridine
carboxylates
dialkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7405678A
Other languages
French (fr)
Other versions
FR2218107B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP48020423A external-priority patent/JPS5930704B2/en
Priority claimed from JP2556673A external-priority patent/JPS49109384A/ja
Priority claimed from JP4482173A external-priority patent/JPS5714348B2/ja
Priority claimed from JP5493973A external-priority patent/JPS504082A/ja
Priority claimed from JP8327673A external-priority patent/JPS5720950B2/ja
Priority claimed from JP13406973A external-priority patent/JPS5545075B2/ja
Priority claimed from JP13407073A external-priority patent/JPS5084577A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2218107A1 publication Critical patent/FR2218107A1/en
Application granted granted Critical
Publication of FR2218107B1 publication Critical patent/FR2218107B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Cpds. (I) (where R is H or alkyl; R1 and R2 are alkyl; R3 is opt. substd. phenyl or aralkyl; R4 is H or alkyl; A is alkylene; R5 is alkyl, alkoxy opt substd. by alkoxy or and R6 is NO2 or CF3) are prepd. froma benzaldehyde. R2 COCH2COON-NR3R4 and R1 C/NHR); CHC OR5 or from pdts. prepd. by reacting two of the starting material with the third. Thus (I. R = H, R1 = R2 = Me, R3 = PhCH2 R = Me, R5 = iso PrO and R6 = 3.NO2) is prepd from beta-(N benzyl-N-methylamino)ethyl acetoacetate, isopropyl beta-aminocrotonate are 3-nitro benzaldehyde.
FR7405678A 1973-02-20 1974-02-20 Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents Granted FR2218107A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP48020423A JPS5930704B2 (en) 1973-02-20 1973-02-20 Method for producing new 1,4-dihydropyridine derivatives
JP2556673A JPS49109384A (en) 1973-03-03 1973-03-03
JP4482173A JPS5714348B2 (en) 1973-04-20 1973-04-20
JP5493973A JPS504082A (en) 1973-05-17 1973-05-17
JP8327673A JPS5720950B2 (en) 1973-07-24 1973-07-24
JP13406973A JPS5545075B2 (en) 1973-11-29 1973-11-29
JP13407073A JPS5084577A (en) 1973-11-29 1973-11-29

Publications (2)

Publication Number Publication Date
FR2218107A1 true FR2218107A1 (en) 1974-09-13
FR2218107B1 FR2218107B1 (en) 1978-03-24

Family

ID=27563904

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7405678A Granted FR2218107A1 (en) 1973-02-20 1974-02-20 Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents

Country Status (1)

Country Link
FR (1) FR2218107A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2431488A1 (en) * 1978-07-17 1980-02-15 Ausonia Farma Srl Vasodilator prepd. by transesterification - is 2-N-benzyl-N-methylamino-ethyl 2,6-di:methyl-4,3-nitrophenyl-3-methoxy-carbonyl-1,4-di:hydro-pyr- idine-5-carboxylate
FR2489146A1 (en) * 1980-03-22 1982-03-05 Yamanouchi Pharma Co Ltd Prolonged release pharmaceutical preparations - contg. a solid medicament e.g. nicardipine in amorphous form, polyethylene oxide and another polymer e.g. PVP

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2051515A1 (en) * 1969-05-10 1971-04-09 Bayer Ag
FR2182983A1 (en) * 1972-04-18 1973-12-14 Bayer Ag

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2051515A1 (en) * 1969-05-10 1971-04-09 Bayer Ag
FR2182983A1 (en) * 1972-04-18 1973-12-14 Bayer Ag

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2431488A1 (en) * 1978-07-17 1980-02-15 Ausonia Farma Srl Vasodilator prepd. by transesterification - is 2-N-benzyl-N-methylamino-ethyl 2,6-di:methyl-4,3-nitrophenyl-3-methoxy-carbonyl-1,4-di:hydro-pyr- idine-5-carboxylate
FR2489146A1 (en) * 1980-03-22 1982-03-05 Yamanouchi Pharma Co Ltd Prolonged release pharmaceutical preparations - contg. a solid medicament e.g. nicardipine in amorphous form, polyethylene oxide and another polymer e.g. PVP

Also Published As

Publication number Publication date
FR2218107B1 (en) 1978-03-24

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Legal Events

Date Code Title Description
CL Concession to grant licenses
CC Supplementary certificate of protection laid open to the public (law of 25 june 1990)

Free format text: 92C0323, 920527

CB Supplementary certificate of protection granted (law of 25 june 1990)

Free format text: 92C0323, 740220

CL Concession to grant licenses