BE811324A - Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents - Google Patents
Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agentsInfo
- Publication number
- BE811324A BE811324A BE141173A BE141173A BE811324A BE 811324 A BE811324 A BE 811324A BE 141173 A BE141173 A BE 141173A BE 141173 A BE141173 A BE 141173A BE 811324 A BE811324 A BE 811324A
- Authority
- BE
- Belgium
- Prior art keywords
- alkyl
- dihydropyridine
- carboxylates
- dialkyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Cpds. (I) (where R is H or alkyl; R1 and R2 are alkyl; R3 is opt. substd. phenyl or aralkyl; R4 is H or alkyl; A is alkylene; R5 is alkyl, alkoxy opt substd. by alkoxy or and R6 is NO2 or CF3) are prepd. froma benzaldehyde. R2 COCH2COON-NR3R4 and R1 C/NHR); CHC OR5 or from pdts. prepd. by reacting two of the starting material with the third. Thus (I. R = H, R1 = R2 = Me, R3 = PhCH2 R = Me, R5 = iso PrO and R6 = 3.NO2) is prepd from beta-(N benzyl-N-methylamino)ethyl acetoacetate, isopropyl beta-aminocrotonate are 3-nitro benzaldehyde.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP48020423A JPS5930704B2 (en) | 1973-02-20 | 1973-02-20 | Method for producing new 1,4-dihydropyridine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BE811324A true BE811324A (en) | 1974-06-17 |
Family
ID=12026610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE141173A BE811324A (en) | 1973-02-20 | 1974-02-20 | Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS5930704B2 (en) |
BE (1) | BE811324A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58159462A (en) * | 1982-03-17 | 1983-09-21 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative |
JPS59227859A (en) * | 1983-06-08 | 1984-12-21 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient |
DK8602336A (en) * | 1985-05-21 | 1986-11-22 | ||
JPS63208574A (en) * | 1987-02-24 | 1988-08-30 | Sanwa Kagaku Kenkyusho Co Ltd | 1,4-dihydropyridine derivative and its salt, their production and drug for circulatory system containing said compound as active component |
-
1973
- 1973-02-20 JP JP48020423A patent/JPS5930704B2/en not_active Expired
-
1974
- 1974-02-20 BE BE141173A patent/BE811324A/en active Protection Beyond IP Right Term
Also Published As
Publication number | Publication date |
---|---|
JPS5930704B2 (en) | 1984-07-28 |
JPS49108082A (en) | 1974-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL7605845A (en) | 2-Hydroxyethylidene cyanoacetic acid anilides - are non ulcerogenic antiphlogistics and analgesics (NL071276) | |
BE811324A (en) | Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents | |
ES423479A1 (en) | N-sulfenylate-N-methyl-carbamic acid esters of 2-oximino-alkanecarboxylic acid nitriles | |
FR2218107A1 (en) | Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents | |
FR2028991A1 (en) | Anilides having herbicidal activity | |
ATE27452T1 (en) | SUBSTITUTED O-PHENYLENE DIAMINE DERIVATIVES. | |
SE7416198L (en) | SALE PRODUCTS OF 4,4-BIS- (HYDROXIMETHYL) -CYCLOHEXENE COMPOUNDS. | |
ES427843A1 (en) | Dioxolanyl carbonyl carboxamides | |
FR2217328A1 (en) | Herbicidal anilides - N-alpha-haloacyl-N-(O-and/or S-contg heterocyclyl-(m)ethyl) -2-alkyl-aniline derivs | |
FR2127929A5 (en) | 4-phenyl-1,2,4-thiadiazolidin-3,5-diones - useful as selective herbicides | |
FR2222375A1 (en) | 5-Substd guanidino barbituric acids - intermediates prepd from a cyanamide and a uramil | |
FR2384498A1 (en) | Antibacterial, antifungal and hypoglycaemic sulphonamido thiazole(s) - prepd. from a phenyl sulphonamide and an isothiocyanato butyne | |
FR2047882A1 (en) | Analgesic antiinflammatory 4-(2-alkoxy - phenylamino-quinolines and intermediates | |
FR2296624A1 (en) | N-(Haloalkylthio)-benzanilide derivs - prepd by reacting haloalkanesulphenyl halides with benzanilide sodio derivs (BE290676) | |
ES435969A1 (en) | Indolobenzazepine derivatives | |
FR2226163A2 (en) | 2-Amino-5-methyl-4-phenyl-1-pyrrolines - with antidepressant and antiarrhythmic activity | |
FR2224447A1 (en) | N-(substd alkyl)-2-alk(enyl)oxybenzamides - antiemetics digestion-regulators and psychotropics | |
SU577207A1 (en) | Antifungal-and antibacterial-active substance | |
FR2309553A1 (en) | (4)-Salicyloyloxy-coumarin derivs. - with antithrombotic activity | |
FR2231656A1 (en) | Substd phenoxy acetates - as water sol herbicides | |
FR2230365A1 (en) | 5-Oxa-prostaglandin analogues - having more specific, longer lasting activity and less side-effects | |
GB1424938A (en) | Process for the production of bis-halogen carbonyl anilines | |
FR2276050A2 (en) | Hypocholesterolaemic diamino-propanols - esp. 1-substd.-amino-3-piperazino-propan-2-ols | |
FR2043463A1 (en) | Benzoxazines and benzothiazines having c n s and | |
FR2224143A1 (en) | Analgesic and antiinflammatory 2-(quinolyl-amino) benzoates - 2-(4-phenyl-piperazino)-ethyl 2-(7-or 8-substd-4-quinolyl-amino)-benzoate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
CCPA | Application for a supplementary protection certificate |
Free format text: 093C0024 |
|
RE20 | Patent expired |
Owner name: YAMANOUCHI PHARMACEUTICAL CO. LTD Effective date: 19940220 |
|
CCPV | Grant of a supplementary protection certificate |
Free format text: 093C0024, EXPIRES:19990220 |