FR2430614A1 - Appareil et procede de chromatographie - Google Patents

Appareil et procede de chromatographie

Info

Publication number
FR2430614A1
FR2430614A1 FR7916708A FR7916708A FR2430614A1 FR 2430614 A1 FR2430614 A1 FR 2430614A1 FR 7916708 A FR7916708 A FR 7916708A FR 7916708 A FR7916708 A FR 7916708A FR 2430614 A1 FR2430614 A1 FR 2430614A1
Authority
FR
France
Prior art keywords
column
chromatography
samples
passed
fractions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7916708A
Other languages
English (en)
Other versions
FR2430614B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Technicon Instruments Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technicon Instruments Corp filed Critical Technicon Instruments Corp
Publication of FR2430614A1 publication Critical patent/FR2430614A1/fr
Application granted granted Critical
Publication of FR2430614B1 publication Critical patent/FR2430614B1/fr
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/44—Flow patterns using recycling of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/44—Flow patterns using recycling of the fraction to be distributed
    • G01N2030/445—Flow patterns using recycling of the fraction to be distributed heart cut
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

L'invention concerne la chromatographie. On fait passer des échantillons, 9 successifs par une première 11 et une seconde colonne de chromatographie 21 en tandem; on fractionne l'éluat de la première colonne et on fait passer les fractions de chacun des échantillons à travers la seconde colonne pour séparation complémentaire, ce fractionnement étant obtenu par commutation de la vanne 15 placée entre la première et la seconde colonne; la vitesse de pompage de la seconde colonne peut être différente de celle de la première colonne et permet à plusieurs fractions d'occuper simultanément la seconde colonne. Amélioration au débit des systèmes de chromatographie liquide ou gazeuse.
FR7916708A 1978-07-07 1979-06-28 Appareil et procede de chromatographie Granted FR2430614A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/922,712 US4204952A (en) 1978-07-07 1978-07-07 Chromatographic apparatus and method

Publications (2)

Publication Number Publication Date
FR2430614A1 true FR2430614A1 (fr) 1980-02-01
FR2430614B1 FR2430614B1 (fr) 1984-10-19

Family

ID=25447483

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7916708A Granted FR2430614A1 (fr) 1978-07-07 1979-06-28 Appareil et procede de chromatographie

Country Status (12)

Country Link
US (1) US4204952A (fr)
JP (1) JPS5512486A (fr)
AU (1) AU518102B2 (fr)
BE (1) BE877273A (fr)
CA (1) CA1132371A (fr)
CH (1) CH639000A5 (fr)
DE (1) DE2926521A1 (fr)
FR (1) FR2430614A1 (fr)
GB (1) GB2024647B (fr)
IT (1) IT1119074B (fr)
NL (1) NL7901754A (fr)
SE (1) SE7901263L (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4392873A (en) * 1981-06-12 1983-07-12 Brockington Francis R Continuous vapor phase chromatography
JPS60219554A (ja) * 1984-04-16 1985-11-02 Yokogawa Hokushin Electric Corp 多量成分中の微量成分を測定する方法およびその装置
EP0207537B1 (fr) * 1985-06-28 1993-01-13 Shell Internationale Researchmaatschappij B.V. Analyseur chromatographique
US4630469A (en) * 1985-09-30 1986-12-23 Phillips Petroleum Company Sample homogenizer
US4724081A (en) * 1986-04-28 1988-02-09 Soken Kagaku Kabushiki Kaisha Process and apparatus for separation by liquid chromatography
DE3717456C1 (de) * 1987-05-23 1988-07-21 Eberhard Gerstel Gaschromatograph und Verfahren zur gaschromatographischen Trennung
US5057437A (en) * 1988-07-27 1991-10-15 Bio-Rad Laboratories, Inc. Method for broad spectrum drug detection
GB2223692A (en) * 1988-09-16 1990-04-18 Philips Nv Liquid chromatography
FI82553C (fi) * 1989-07-04 1991-03-11 Valtion Teknillinen Foerfarande och anordning foer kromatografisk separation.
JP2834224B2 (ja) * 1989-10-18 1998-12-09 株式会社日立製作所 液体クロマトグラフィーによる試料の分析装置
US5071547A (en) * 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
US5281256A (en) * 1990-09-28 1994-01-25 Regents Of The University Of Michigan Gas chromatography system with column bifurcation and tunable selectivity
JPH06138115A (ja) * 1991-04-25 1994-05-20 Shimadzu Corp 試料成分分取装置
US5288310A (en) * 1992-09-30 1994-02-22 The Regents Of The University Of Michigan Adsorbent trap for gas chromatography
US5346622A (en) * 1993-03-04 1994-09-13 Hewlett-Packard Company Hydrocarbon class separation and quantitation by split column effluent analysis
US5352585A (en) * 1993-06-29 1994-10-04 Bio-Rad Laboratories, Inc. System for benzodiazepine detection
DE19711173A1 (de) * 1997-03-18 1998-09-24 Sartorius Gmbh Verfahren und Anlage für die adsorptive Stofftrennung
FR2787576B1 (fr) 1998-12-22 2001-01-12 Inst Francais Du Petrole Procede et dispositif d'analyse integree pour la caracterisation d'hydrocarbures, par simulation de distillation
GB0025018D0 (en) * 2000-10-12 2000-11-29 Micromass Ltd Apparatus method for isotopically analysing samples
US6632268B2 (en) * 2001-02-08 2003-10-14 Oakland University Method and apparatus for comprehensive two-dimensional gas chromatography
US7089763B2 (en) * 2002-02-25 2006-08-15 Worldwide Water, L.L.C. Portable, potable water recovery and dispensing apparatus
US10948483B2 (en) 2013-04-08 2021-03-16 Chromacon Ag Method for control, monitoring and/or optimization of a chromatographic process
US10099156B2 (en) 2013-04-08 2018-10-16 Chromacon Ag Chromatographic purification method
EP3519808B1 (fr) * 2016-09-28 2023-04-05 Evosep ApS Analyse chromatographique à refocalisation de gradient double à basse pression
CN109923413A (zh) * 2016-11-15 2019-06-21 株式会社资生堂 多级色谱分析方法及分析系统

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3159019A (en) * 1959-07-17 1964-12-01 Phillips Petroleum Co Chromatographic analysis method
US3263488A (en) * 1963-03-04 1966-08-02 Hewlett Packard Co Method for gas chromatography
US3385101A (en) * 1964-11-16 1968-05-28 Phillips Petroleum Co Chromatographic analyzer
FR1546865A (fr) * 1966-11-21 1968-11-22 Shell Int Research Procédé et appareil de séparation chromatographique d'un mélange
US3508880A (en) * 1966-01-07 1970-04-28 Ceskoslovenska Akademie Ved Apparatus for carrying out chromatographic analyses of amino acids,their mixtures and similar materials
US3992175A (en) * 1974-02-11 1976-11-16 Toe Jokhannesovich Klementi Method of and device for chromatographic separation of fluid mixtures into fractions
US4070284A (en) * 1973-08-20 1978-01-24 Hitachi, Ltd. Liquid chromatography and apparatus for the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002583A (en) * 1957-06-10 1961-10-03 Phillips Petroleum Co Fluid separation by gas chromatography
DE1598205B1 (de) * 1964-04-13 1971-05-19 Ceskoslovenska Akademie Ved Einrichtung zur chromatographie von aminosaeuren und derglei chen enthaltenden gemischen
US4001112A (en) * 1972-06-14 1977-01-04 Philip Edwin Barker Method of operating a chromatographic apparatus
US3918906A (en) * 1973-08-06 1975-11-11 Dow Chemical Co Determining total ionic content
US3897213A (en) * 1973-08-06 1975-07-29 Dow Chemical Co Automated quantitative analysis of ionic species
FR2300607A1 (fr) * 1975-02-13 1976-09-10 Erap Proce

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3159019A (en) * 1959-07-17 1964-12-01 Phillips Petroleum Co Chromatographic analysis method
US3263488A (en) * 1963-03-04 1966-08-02 Hewlett Packard Co Method for gas chromatography
US3385101A (en) * 1964-11-16 1968-05-28 Phillips Petroleum Co Chromatographic analyzer
US3508880A (en) * 1966-01-07 1970-04-28 Ceskoslovenska Akademie Ved Apparatus for carrying out chromatographic analyses of amino acids,their mixtures and similar materials
FR1546865A (fr) * 1966-11-21 1968-11-22 Shell Int Research Procédé et appareil de séparation chromatographique d'un mélange
US4070284A (en) * 1973-08-20 1978-01-24 Hitachi, Ltd. Liquid chromatography and apparatus for the same
US3992175A (en) * 1974-02-11 1976-11-16 Toe Jokhannesovich Klementi Method of and device for chromatographic separation of fluid mixtures into fractions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF CHROMATOGRAPHIC SCIENCE, volume 8, décembre 1970, (US), L.R. SNYDER 'Comparisons of normal elution, coupled columns, and solvent flow or temperature programming in liquid chromatography', pages 692 - 706 *

Also Published As

Publication number Publication date
CA1132371A (fr) 1982-09-28
IT1119074B (it) 1986-03-03
NL7901754A (nl) 1980-01-09
US4204952A (en) 1980-05-27
DE2926521C2 (fr) 1989-05-11
AU4542379A (en) 1980-01-10
JPS5512486A (en) 1980-01-29
GB2024647A (en) 1980-01-16
AU518102B2 (en) 1981-09-10
GB2024647B (en) 1982-09-29
FR2430614B1 (fr) 1984-10-19
IT7967901A0 (it) 1979-04-27
CH639000A5 (de) 1983-10-31
SE7901263L (sv) 1980-01-08
BE877273A (fr) 1979-12-27
DE2926521A1 (de) 1980-01-17

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