FR2425427A1 - Procede pour la preparation de l'acide a-(4-(4-chlorobenzoylamino-ethyl)phenoxy)isobutyrique - Google Patents

Procede pour la preparation de l'acide a-(4-(4-chlorobenzoylamino-ethyl)phenoxy)isobutyrique

Info

Publication number
FR2425427A1
FR2425427A1 FR7911966A FR7911966A FR2425427A1 FR 2425427 A1 FR2425427 A1 FR 2425427A1 FR 7911966 A FR7911966 A FR 7911966A FR 7911966 A FR7911966 A FR 7911966A FR 2425427 A1 FR2425427 A1 FR 2425427A1
Authority
FR
France
Prior art keywords
chlorobenzoylamino
ethyl
preparation
phenoxy
isobutyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7911966A
Other languages
English (en)
Other versions
FR2425427B1 (fr
Inventor
Peter Dr Beyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of FR2425427A1 publication Critical patent/FR2425427A1/fr
Application granted granted Critical
Publication of FR2425427B1 publication Critical patent/FR2425427B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Abstract

PROCEDE POUR LA PREPARATION DE 2-4-(4-CHLOROBENZOYLAMINO-ETHYL)PHENOXY2-METHYLPROPIONIQUE DE FORMULE: (CF DESSIN DANS BOPI) CARACTERISE EN CE QUE L'ON FAIT REAGIR UNE MOLE DE N-(4-CHLOROBENZOYL)TYRAMINE AVEC 20 A 100 MOLES D'ACETONE, 2 A 10, DE PREFERENCE DE 3 A 6 MOLES DE CHLOROFORME ET 3 A 4, DE PREFERENCE 3,2 A 3,5 MOLES D'ALCALI PAR MOLE DE CHLOROFORME DANS UN DOMAINE DE TEMPERATURE COMPRIS ENVIRON ENTRE 10 ET 40C, DE PREFERENCE ENTRE 15 ET 30C.
FR7911966A 1978-05-12 1979-05-11 Procede pour la preparation de l'acide a-(4-(4-chlorobenzoylamino-ethyl)phenoxy)isobutyrique Expired FR2425427B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2820759 1978-05-12

Publications (2)

Publication Number Publication Date
FR2425427A1 true FR2425427A1 (fr) 1979-12-07
FR2425427B1 FR2425427B1 (fr) 1984-08-24

Family

ID=6039192

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7911966A Expired FR2425427B1 (fr) 1978-05-12 1979-05-11 Procede pour la preparation de l'acide a-(4-(4-chlorobenzoylamino-ethyl)phenoxy)isobutyrique

Country Status (22)

Country Link
US (1) US4370495A (fr)
JP (1) JPS5649906B2 (fr)
AR (1) AR219595A1 (fr)
AT (1) AT365167B (fr)
AU (1) AU520908B2 (fr)
BE (1) BE876162A (fr)
CA (1) CA1124260A (fr)
CH (1) CH641762A5 (fr)
CS (1) CS203960B2 (fr)
DD (1) DD143520A5 (fr)
DK (1) DK187579A (fr)
FI (1) FI791466A (fr)
FR (1) FR2425427B1 (fr)
GB (1) GB2021575B (fr)
HU (1) HU177958B (fr)
IL (1) IL57220A (fr)
IT (1) IT1166786B (fr)
NL (1) NL183185C (fr)
PL (1) PL114686B1 (fr)
SE (1) SE433609B (fr)
SU (1) SU828962A3 (fr)
YU (1) YU41438B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102707A (en) * 1992-08-02 1996-11-14 Cherkez Stephen Processes for the preparation of tyramine derivatives
ES2105003T3 (es) * 1993-05-12 1997-10-16 Heumann Pharma Gmbh & Co Forma estable y cristalina del bezafibrato.
CN101353315B (zh) * 2008-08-08 2011-05-11 淮阴工学院 一种苯扎贝特的制备方法
CN101445467B (zh) * 2008-12-30 2013-01-23 浙江九洲药业股份有限公司 N-(4-氯苯甲酰基)-酪胺的化学合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2154739A1 (fr) * 1971-10-01 1973-05-11 Boehringer Mannheim Gmbh
FR2259597A1 (fr) * 1974-02-06 1975-08-29 Boehringer Mannheim Gmbh
FR2324295A1 (fr) * 1975-09-17 1977-04-15 Boehringer Mannheim Gmbh Nouveaux acides phenoxyalcoylcarboxyliques et procede permettant leur production

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2108980A1 (en) * 1970-10-27 1972-05-26 Biosedra Lab Pure ethyl alpha-p-iodophenoxyisobutyrate - with hypolipaemic activity
US3948973A (en) * 1972-08-29 1976-04-06 Sterling Drug Inc. Halocyclopropyl substituted phenoxyalkanoic acids
GB1422679A (en) * 1972-11-16 1976-01-28 Funai Pharmaceutical Ind Ltd Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same
JPS5735171B2 (fr) * 1973-07-02 1982-07-27

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2154739A1 (fr) * 1971-10-01 1973-05-11 Boehringer Mannheim Gmbh
FR2259597A1 (fr) * 1974-02-06 1975-08-29 Boehringer Mannheim Gmbh
FR2324295A1 (fr) * 1975-09-17 1977-04-15 Boehringer Mannheim Gmbh Nouveaux acides phenoxyalcoylcarboxyliques et procede permettant leur production

Also Published As

Publication number Publication date
AU520908B2 (en) 1982-03-04
FI791466A (fi) 1979-11-13
BE876162A (fr) 1979-11-12
DD143520A5 (de) 1980-08-27
SE433609B (sv) 1984-06-04
AU4679079A (en) 1979-11-15
CH641762A5 (de) 1984-03-15
ATA352979A (de) 1981-05-15
AT365167B (de) 1981-12-28
SE7904008L (sv) 1979-11-13
IT7922464A0 (it) 1979-05-08
GB2021575B (en) 1982-07-07
HU177958B (en) 1982-02-28
GB2021575A (en) 1979-12-05
YU109879A (en) 1982-10-31
IL57220A0 (en) 1979-09-30
CS203960B2 (en) 1981-03-31
AR219595A1 (es) 1980-08-29
SU828962A3 (ru) 1981-05-07
NL183185C (nl) 1988-08-16
DK187579A (da) 1979-11-13
JPS54148742A (en) 1979-11-21
IL57220A (en) 1982-04-30
US4370495A (en) 1983-01-25
PL114686B1 (en) 1981-02-28
YU41438B (en) 1987-06-30
CA1124260A (fr) 1982-05-25
JPS5649906B2 (en) 1981-11-25
FR2425427B1 (fr) 1984-08-24
IT1166786B (it) 1987-05-06
NL7903631A (nl) 1979-11-14

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0348, 920527

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0348, 790511

CL Concession to grant licences