FR2424918A1 - Nouvelles piperazines substituees, leur preparation et leur utilisation - Google Patents

Nouvelles piperazines substituees, leur preparation et leur utilisation

Info

Publication number
FR2424918A1
FR2424918A1 FR7911350A FR7911350A FR2424918A1 FR 2424918 A1 FR2424918 A1 FR 2424918A1 FR 7911350 A FR7911350 A FR 7911350A FR 7911350 A FR7911350 A FR 7911350A FR 2424918 A1 FR2424918 A1 FR 2424918A1
Authority
FR
France
Prior art keywords
preparation
new substituted
substituted piperazines
piperazines
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7911350A
Other languages
English (en)
Other versions
FR2424918B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2424918A1 publication Critical patent/FR2424918A1/fr
Application granted granted Critical
Publication of FR2424918B1 publication Critical patent/FR2424918B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

LA PRESENTE INVENTION EST RELATIVE A DE NOUVELLES PIPERAZINES SUBSTITUEES, A LEUR PREPARATION AINSI QU'A LEUR UTILISATION. SUIVANT L'INVENTION, CES PIPERAZINES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE X REPRESENTE UN RADICAL CHLORO OU TRIFLUOROMETHYLE, R EST UN RADICAL TRIAZINYLE, PYRAZINYLE, PYRIDINYLE, PYRIMIDINYLE OU PHENYLE SUBSTITUE OU NON, OU BIEN R
FR7911350A 1978-05-05 1979-05-04 Nouvelles piperazines substituees, leur preparation et leur utilisation Granted FR2424918A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/903,200 US4159331A (en) 1978-05-05 1978-05-05 Antihypertensive 4-aminoquinolines

Publications (2)

Publication Number Publication Date
FR2424918A1 true FR2424918A1 (fr) 1979-11-30
FR2424918B1 FR2424918B1 (fr) 1983-01-14

Family

ID=25417100

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7911350A Granted FR2424918A1 (fr) 1978-05-05 1979-05-04 Nouvelles piperazines substituees, leur preparation et leur utilisation

Country Status (9)

Country Link
US (1) US4159331A (fr)
JP (1) JPS54145684A (fr)
AU (1) AU521589B2 (fr)
BE (1) BE876040A (fr)
DE (1) DE2914491A1 (fr)
FR (1) FR2424918A1 (fr)
GB (1) GB2021568B (fr)
IT (1) IT1113369B (fr)
NL (1) NL7903510A (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871843A (en) * 1983-10-18 1989-10-03 Dropic-Societe Civile De Gestion De Droits De Propriete Industrielle Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions
FR2553414B1 (fr) * 1983-10-18 1986-08-14 Choay Sa Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques
GB8424979D0 (en) * 1984-10-03 1984-11-07 Wyeth John & Brother Ltd Benzenesulphonamide derivatives
EP0215902A1 (fr) * 1985-03-13 1987-04-01 The Upjohn Company Procede de preparation de 4-amino quinolines
US5149700A (en) * 1990-05-30 1992-09-22 American Home Products Corporation Substituted arylsulfonamides and benzamides
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
AU3248600A (en) * 1999-03-03 2000-09-21 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
AU2006326540A1 (en) * 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
BRPI0709612A2 (pt) * 2006-03-15 2011-07-19 Wyeth Corp composto de fórmula i; método para o tratamento de um distúrbio no sistema nervoso central relacionado ou afetado pelo receptor histamina-3 em um paciente que necessita deste tratamento; método para a inibição do receptor h3; composição farmacêutica; e processo para a preparação de um composto de fórmula i
MX2008014743A (es) * 2006-05-19 2008-12-01 Wyeth Corp N-benzoil- y n-bencilpirrolidin-3-ilaminas como antagonistas de histamina-3.
PE20081152A1 (es) * 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3
CN101778838A (zh) * 2007-05-24 2010-07-14 惠氏有限责任公司 作为组胺-3拮抗剂的氮杂环基苯甲酰胺衍生物
JP2010533725A (ja) * 2007-07-16 2010-10-28 ワイス・エルエルシー ヒスタミン‐３（ｈ３）受容体としてのアミノアルキルアゾール化合物
TW200918062A (en) * 2007-09-12 2009-05-01 Wyeth Corp Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists
CA2699384A1 (fr) * 2007-09-12 2009-03-19 Wyeth Llc Derives d'isoquinolinyle et d'isoindolinyle convenant comme antagonistes de l'histamine-3
US9783515B2 (en) 2013-05-07 2017-10-10 The Regents Of The University Of California Radiomitigating pharmaceutical formulations
CR20160428A (es) 2014-02-14 2017-04-04 Takeda Pharmaceuticals Co Pizazinas moduladoras de gpr6
JP2022505264A (ja) 2018-10-17 2022-01-14 デューク・ユニヴァーシティ 神経保護剤として使用するためのキノンレダクターゼ２阻害剤
AU2020337892A1 (en) * 2019-08-24 2022-05-19 BCN Biosciences L.L.C. Methods of treatment using BCN057 and BCN512

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2229413A1 (en) * 1973-05-17 1974-12-13 Upjohn Co Para-4-quinolyl amino benzene sulphonamides - from a 4-chloro quinoline and a p-amino benzene sulphonamide, hypotensives etc.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3992382A (en) * 1973-06-15 1976-11-16 The Upjohn Company Quinolylaminobenzoylpiperazine-1-oxides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2229413A1 (en) * 1973-05-17 1974-12-13 Upjohn Co Para-4-quinolyl amino benzene sulphonamides - from a 4-chloro quinoline and a p-amino benzene sulphonamide, hypotensives etc.

Also Published As

Publication number Publication date
FR2424918B1 (fr) 1983-01-14
NL7903510A (nl) 1979-11-07
DE2914491A1 (de) 1979-11-08
AU4667279A (en) 1979-11-08
BE876040A (fr) 1979-11-05
IT7922089A0 (it) 1979-04-23
GB2021568B (en) 1982-08-04
GB2021568A (en) 1979-12-05
AU521589B2 (en) 1982-04-22
JPS54145684A (en) 1979-11-14
US4159331A (en) 1979-06-26
IT1113369B (it) 1986-01-20

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Legal Events

Date Code Title Description
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