FR2424915A1 - Nouveaux derives d'acides /4h/ 1-3 benzodioxin-2-carboxyliques, un procede pour leur preparation et leur application comme medicaments - Google Patents

Nouveaux derives d'acides /4h/ 1-3 benzodioxin-2-carboxyliques, un procede pour leur preparation et leur application comme medicaments

Info

Publication number
FR2424915A1
FR2424915A1 FR7813095A FR7813095A FR2424915A1 FR 2424915 A1 FR2424915 A1 FR 2424915A1 FR 7813095 A FR7813095 A FR 7813095A FR 7813095 A FR7813095 A FR 7813095A FR 2424915 A1 FR2424915 A1 FR 2424915A1
Authority
FR
France
Prior art keywords
alkyl
useful
angina
halo
cyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7813095A
Other languages
English (en)
Other versions
FR2424915B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7813095A priority Critical patent/FR2424915A1/fr
Priority to SE7902817A priority patent/SE445553B/sv
Priority to SE7902817D priority patent/SE7902817L/xx
Priority to US06/034,432 priority patent/US4281012A/en
Priority to ES480163A priority patent/ES480163A1/es
Priority to DK180179A priority patent/DK180179A/da
Priority to NL7903436A priority patent/NL7903436A/xx
Priority to IT7948908A priority patent/IT1116836B/it
Priority to JP5352279A priority patent/JPS54144382A/ja
Priority to BE0/194947A priority patent/BE875986A/fr
Priority to CH414479A priority patent/CH640233A5/fr
Priority to GB7915447A priority patent/GB2022579B/en
Priority to DE19792917902 priority patent/DE2917902A1/de
Publication of FR2424915A1 publication Critical patent/FR2424915A1/fr
Application granted granted Critical
Publication of FR2424915B1 publication Critical patent/FR2424915B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms using aldehydes or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/373—Halogenated derivatives with all hydroxy groups on non-condensed rings and with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION A POUR OBJET LES PRODUITS DE FORMULE GENERALE I DANS LAQUELLE: (CF DESSIN DANS BOPI) RHYDROGENE, ALCOYLE (C1-C5), DIALCOYLAMINOALCOYLE (ALCOYLEC1-C5), (2, 3-DIHYDROXYPROPANYL), (2-2-DIMETHYL 1,3-DIOXOLAN-4-YL) METHYLE,RHYDROGENE OU ALCOYLE (C1-C5),R ET R, IDENTIQUES OU DIFFERENTSHYDROGENE, ALCOYLE (C1-C5), CYCLOHEXYLE OU BIEN R ET R FORMENT ENSEMBLE AVEC L'ATOME DE CARBONE AUQUEL ILS SONT LIES, UN RADICAL CYCLOHEXANE, ETRHYDROGENE OU HALOGENE, SOUS FORMES RACEMIQUES OU OPTIQUEMENT ACTIVES AINSI QUE LES SELS ALCALINS, ALCALINO-TERREUX, D'ALUMINIUM, D'AMMONIUM ET D'AMINES DES PRODUITS DE FORMULE I CI-DESSUS, DANS LAQUELLE R REPRESENTE UN ATOME D'HYDROGENE, AINSI QUE LES SELS D'ADDITION D'ACIDES DE PRODUITS DE FORMULE I CI-DESSUS, DANS LAQUELLE RDIALCOYLAMINOALCOYLE, UN PROCEDE POUR LEUR PREPARATION ET LEUR APPLICATION COMME MEDICAMENTS.
FR7813095A 1978-05-03 1978-05-03 Nouveaux derives d'acides /4h/ 1-3 benzodioxin-2-carboxyliques, un procede pour leur preparation et leur application comme medicaments Granted FR2424915A1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR7813095A FR2424915A1 (fr) 1978-05-03 1978-05-03 Nouveaux derives d'acides /4h/ 1-3 benzodioxin-2-carboxyliques, un procede pour leur preparation et leur application comme medicaments
SE7902817A SE445553B (sv) 1978-05-03 1979-03-29 /4h/-1,3-bensodioxan-2-karboxylsyraderivat
SE7902817D SE7902817L (sv) 1978-05-03 1979-03-29 Substituerade /4h/ 1,3-bensodioxin-2-karboxylsyraderivat, framstellning och anvendning derav sasom lekemedel samt farmaceutiska kompositioner innehallande dessa
US06/034,432 US4281012A (en) 1978-05-03 1979-04-30 [4H]-1,3-Benzodioxin-2-carboxylic acids
DK180179A DK180179A (da) 1978-05-03 1979-05-02 Fremgangsmaade ril fremstilling af substituerede derivater af 4h-1,3-benzodioxin-2-carboxylsyrer
NL7903436A NL7903436A (nl) 1978-05-03 1979-05-02 Nieuwe gesubstitueerde-(4h)-1,3-benzodioxine-2-carbon- zuurderivaten, werkwijze ter bereiding van deze deri- vaten en farmaceutische preparaten, waarin ze zijn op- genomen.
ES480163A ES480163A1 (es) 1978-05-03 1979-05-02 Procedimiento de preparacion de nuevos derivados sustituidos de acidos 4h-1-benzodioxin-2- carboxilicos.
IT7948908A IT1116836B (it) 1978-05-03 1979-05-02 Derivati originali sostituiti di acidi 4h 1,3-benzodiossin 2-carnos stiton procedimento per la loro produzione loro impiego come medicamenti e composizoni farmaceutiche cheli contingono
JP5352279A JPS54144382A (en) 1978-05-03 1979-05-02 Novel substituted derivative of *4h**1*33benzodioxinee22carboxylic acid*its manufacture*use as drug and pharmaceutic composition containing it
BE0/194947A BE875986A (fr) 1978-05-03 1979-05-02 Nouveaux derives substitues d'acides/4h/1,3-benzodioxin 2-carboxyliques, procede pour leur preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
CH414479A CH640233A5 (fr) 1978-05-03 1979-05-03 Acides (4h) 1,3-benzodioxine 2-carboxyliques substitues et leurs esters, procedes pour leur preparation et compositions pharmaceutiques les renfermant.
GB7915447A GB2022579B (en) 1978-05-03 1979-05-03 4h-1,3-benzodioxin-2-carboxylic acid derivatives
DE19792917902 DE2917902A1 (de) 1978-05-03 1979-05-03 Neue substituierte derivate von eckige klammer auf 4 h eckige klammer zu- 1,3-benzodioxin-2-carbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung als pharmazeutische zusammensetzungen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7813095A FR2424915A1 (fr) 1978-05-03 1978-05-03 Nouveaux derives d'acides /4h/ 1-3 benzodioxin-2-carboxyliques, un procede pour leur preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
FR2424915A1 true FR2424915A1 (fr) 1979-11-30
FR2424915B1 FR2424915B1 (fr) 1981-10-30

Family

ID=9207867

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7813095A Granted FR2424915A1 (fr) 1978-05-03 1978-05-03 Nouveaux derives d'acides /4h/ 1-3 benzodioxin-2-carboxyliques, un procede pour leur preparation et leur application comme medicaments

Country Status (2)

Country Link
BE (1) BE875986A (fr)
FR (1) FR2424915A1 (fr)

Also Published As

Publication number Publication date
FR2424915B1 (fr) 1981-10-30
BE875986A (fr) 1979-11-05

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