FR2422396A1 - Vehicule compose d'un phospholipide et d'un lipide non miscible, destine a liberer une substance xenobiotique dans l'organisme d'un mammifere - Google Patents
Vehicule compose d'un phospholipide et d'un lipide non miscible, destine a liberer une substance xenobiotique dans l'organisme d'un mammifereInfo
- Publication number
- FR2422396A1 FR2422396A1 FR7909464A FR7909464A FR2422396A1 FR 2422396 A1 FR2422396 A1 FR 2422396A1 FR 7909464 A FR7909464 A FR 7909464A FR 7909464 A FR7909464 A FR 7909464A FR 2422396 A1 FR2422396 A1 FR 2422396A1
- Authority
- FR
- France
- Prior art keywords
- phospholipid
- substance
- mammal
- organism
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title abstract 7
- 239000002676 xenobiotic agent Substances 0.000 title abstract 4
- 230000002034 xenobiotic effect Effects 0.000 title abstract 4
- 150000003904 phospholipids Chemical class 0.000 title abstract 3
- 241000124008 Mammalia Species 0.000 title abstract 2
- 150000002632 lipids Chemical class 0.000 title abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003633 blood substitute Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention a trait au domaine de la chimie médicale Elle concerne un véhicule apte à délivrer une substance xénobiotique à l'organisme d'un mammifère de manière à modifier dans un sens bénéfique la pharmacodynamique (par exemple la cinétique dans le plasma, l'efficacité chimiothérapeutique, la toxicité l'absorption orale, la distribution dans les tissus, le métabolisme, etc.) de ladite substance Le véhicule distributeur se présente sous la forme de microréservoirs formés d'un constituant phospholipidique et d'un constituant lipidique non miscible au phospholipide. Des agents modifiant la liaison et la vitesse de libération de la substance xénobiotique peuvent aussi être ajoutés. L'invention concerne également des procédés de préparation des microréservoirs contenant la substance xénobiotique. Les substances xénohiotiques comprennent à titre non limitatif des médicaments, des agents diagnostiques, des substituts du sang, des substances biologiques endogènes, des hormones, des adjuvants immunologiques, etc.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89631178A | 1978-04-14 | 1978-04-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2422396A1 true FR2422396A1 (fr) | 1979-11-09 |
| FR2422396B1 FR2422396B1 (fr) | 1983-03-11 |
Family
ID=25405992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7909464A Granted FR2422396A1 (fr) | 1978-04-14 | 1979-04-13 | Vehicule compose d'un phospholipide et d'un lipide non miscible, destine a liberer une substance xenobiotique dans l'organisme d'un mammifere |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5513260A (fr) |
| CA (1) | CA1119955A (fr) |
| CH (1) | CH637825A5 (fr) |
| DE (1) | DE2915028A1 (fr) |
| FR (1) | FR2422396A1 (fr) |
| GB (1) | GB2018712B (fr) |
| IT (1) | IT1193471B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55153713A (en) * | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
| EP0280394B1 (fr) * | 1987-01-27 | 1994-12-14 | Vestar, Inc. | Véhicule de délivrance à base de phospholipides pour des ingrédients actifs insolubles dans l'eau |
| GB2326337A (en) | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
| WO2005053643A1 (fr) * | 2003-12-01 | 2005-06-16 | Mitsubishi Pharma Corporation | Liposome |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2278321A1 (fr) * | 1974-07-19 | 1976-02-13 | Battelle Memorial Institute | Procede de preparation de liposomes |
-
1979
- 1979-03-23 CA CA000324080A patent/CA1119955A/fr not_active Expired
- 1979-04-12 GB GB7913056A patent/GB2018712B/en not_active Expired
- 1979-04-12 CH CH353579A patent/CH637825A5/fr not_active IP Right Cessation
- 1979-04-12 DE DE19792915028 patent/DE2915028A1/de not_active Ceased
- 1979-04-13 JP JP4447779A patent/JPS5513260A/ja active Pending
- 1979-04-13 FR FR7909464A patent/FR2422396A1/fr active Granted
- 1979-04-13 IT IT21861/79A patent/IT1193471B/it active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2278321A1 (fr) * | 1974-07-19 | 1976-02-13 | Battelle Memorial Institute | Procede de preparation de liposomes |
Non-Patent Citations (1)
| Title |
|---|
| CA1979 * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2018712B (en) | 1982-09-08 |
| IT1193471B (it) | 1988-07-08 |
| FR2422396B1 (fr) | 1983-03-11 |
| DE2915028A1 (de) | 1979-12-13 |
| JPS5513260A (en) | 1980-01-30 |
| CH637825A5 (fr) | 1983-08-31 |
| GB2018712A (en) | 1979-10-24 |
| CA1119955A (fr) | 1982-03-16 |
| IT7921861A0 (it) | 1979-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |