FR2401935A1 - Nouveaux 25-alkylcholesterols utiles notamment comme hypocholesterolemiants et leur procede de preparation - Google Patents

Nouveaux 25-alkylcholesterols utiles notamment comme hypocholesterolemiants et leur procede de preparation

Info

Publication number
FR2401935A1
FR2401935A1 FR7824922A FR7824922A FR2401935A1 FR 2401935 A1 FR2401935 A1 FR 2401935A1 FR 7824922 A FR7824922 A FR 7824922A FR 7824922 A FR7824922 A FR 7824922A FR 2401935 A1 FR2401935 A1 FR 2401935A1
Authority
FR
France
Prior art keywords
hypocholesterolemiants
alkylcholesterols
useful
new
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7824922A
Other languages
English (en)
French (fr)
Other versions
FR2401935B1 (it
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of FR2401935A1 publication Critical patent/FR2401935A1/fr
Application granted granted Critical
Publication of FR2401935B1 publication Critical patent/FR2401935B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7824922A 1977-08-29 1978-08-29 Nouveaux 25-alkylcholesterols utiles notamment comme hypocholesterolemiants et leur procede de preparation Granted FR2401935A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82838577A 1977-08-29 1977-08-29

Publications (2)

Publication Number Publication Date
FR2401935A1 true FR2401935A1 (fr) 1979-03-30
FR2401935B1 FR2401935B1 (it) 1981-07-10

Family

ID=25251653

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7824922A Granted FR2401935A1 (fr) 1977-08-29 1978-08-29 Nouveaux 25-alkylcholesterols utiles notamment comme hypocholesterolemiants et leur procede de preparation

Country Status (9)

Country Link
JP (1) JPS5448751A (it)
AU (1) AU520334B2 (it)
CA (1) CA1113086A (it)
CH (1) CH643566A5 (it)
DE (1) DE2837414A1 (it)
ES (1) ES472877A1 (it)
FR (1) FR2401935A1 (it)
GB (1) GB2009180B (it)
IT (1) IT1106121B (it)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462444A1 (fr) * 1979-07-30 1981-02-13 Searle & Co 25-halogeno-5-cholestene-3b, 22-diols et leurs esters utiles notamment comme hypocholesterolemiants
EP0069304A1 (en) * 1981-06-29 1983-01-12 G.D. Searle & Co. 24-Cyclopropylcholene-3 beta, 22-diols and esters thereof
FR2516087A1 (fr) * 1981-11-09 1983-05-13 Searle & Co 5a-cholestane-3b, 22s-diols substitues en position 25 et leurs esters, et leurs utilisations therapeutiques en tant qu'inhibiteurs de la biosynthese du cholesterol
EP0562849A2 (en) * 1992-03-27 1993-09-29 Eli Lilly And Company Steroid derivatives

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225525A (en) * 1979-02-08 1980-09-30 Hoffmann-La Roche Inc. Vitamin D3 metabolite derivatives
US6518262B1 (en) 1999-03-09 2003-02-11 Akzo Nobel N.V. 22R-hydroxycholesta-8, 14-diene derivatives for the inhibition of meiosis
JP2005508281A (ja) * 2001-02-08 2005-03-31 ザ ユニバーシティー オブ シカゴ ステロイド誘導体
US7078396B2 (en) 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
JP2013500986A (ja) 2009-07-29 2013-01-10 ザ・ユニバーシティ・オブ・シカゴ 肝臓ｘ受容体アゴニスト

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1976 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462444A1 (fr) * 1979-07-30 1981-02-13 Searle & Co 25-halogeno-5-cholestene-3b, 22-diols et leurs esters utiles notamment comme hypocholesterolemiants
EP0069304A1 (en) * 1981-06-29 1983-01-12 G.D. Searle & Co. 24-Cyclopropylcholene-3 beta, 22-diols and esters thereof
FR2516087A1 (fr) * 1981-11-09 1983-05-13 Searle & Co 5a-cholestane-3b, 22s-diols substitues en position 25 et leurs esters, et leurs utilisations therapeutiques en tant qu'inhibiteurs de la biosynthese du cholesterol
EP0562849A2 (en) * 1992-03-27 1993-09-29 Eli Lilly And Company Steroid derivatives
EP0562849A3 (it) * 1992-03-27 1994-02-16 Lilly Co Eli

Also Published As

Publication number Publication date
CA1113086A (en) 1981-11-24
IT7850879A0 (it) 1978-08-28
DE2837414A1 (de) 1979-03-08
ES472877A1 (es) 1979-02-16
AU520334B2 (en) 1982-01-28
AU3931878A (en) 1980-03-06
GB2009180A (en) 1979-06-13
IT1106121B (it) 1985-11-11
DE2837414C2 (it) 1987-09-03
JPS5448751A (en) 1979-04-17
FR2401935B1 (it) 1981-07-10
CH643566A5 (de) 1984-06-15
JPS6259720B2 (it) 1987-12-12
GB2009180B (en) 1982-05-26

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Legal Events

Date Code Title Description
ST Notification of lapse