FR2396758A1 - Nouveaux 2-thioethers d'ergoline et leurs sulfoxydes, utiles notamment comme bloqueurs des centres adrenergiques a et leurs procedes de preparation - Google Patents

Nouveaux 2-thioethers d'ergoline et leurs sulfoxydes, utiles notamment comme bloqueurs des centres adrenergiques a et leurs procedes de preparation

Info

Publication number
FR2396758A1
FR2396758A1 FR7820054A FR7820054A FR2396758A1 FR 2396758 A1 FR2396758 A1 FR 2396758A1 FR 7820054 A FR7820054 A FR 7820054A FR 7820054 A FR7820054 A FR 7820054A FR 2396758 A1 FR2396758 A1 FR 2396758A1
Authority
FR
France
Prior art keywords
thioethers
sulfoxides
blockers
useful
preparation methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7820054A
Other languages
English (en)
Other versions
FR2396758B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIMES Societa Italiana Medicinali e Sintetici SpA
Original Assignee
SIMES Societa Italiana Medicinali e Sintetici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SIMES Societa Italiana Medicinali e Sintetici SpA filed Critical SIMES Societa Italiana Medicinali e Sintetici SpA
Publication of FR2396758A1 publication Critical patent/FR2396758A1/fr
Application granted granted Critical
Publication of FR2396758B1 publication Critical patent/FR2396758B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Les médicaments selon l'invention répondent à la formule générale :
FR7820054A 1977-07-05 1978-07-05 Nouveaux 2-thioethers d'ergoline et leurs sulfoxydes, utiles notamment comme bloqueurs des centres adrenergiques a et leurs procedes de preparation Granted FR2396758A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH825577 1977-07-05

Publications (2)

Publication Number Publication Date
FR2396758A1 true FR2396758A1 (fr) 1979-02-02
FR2396758B1 FR2396758B1 (fr) 1981-06-26

Family

ID=4337542

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7820054A Granted FR2396758A1 (fr) 1977-07-05 1978-07-05 Nouveaux 2-thioethers d'ergoline et leurs sulfoxydes, utiles notamment comme bloqueurs des centres adrenergiques a et leurs procedes de preparation

Country Status (7)

Country Link
US (1) US4197299A (fr)
JP (1) JPS5414999A (fr)
BE (1) BE868768A (fr)
DE (1) DE2829471A1 (fr)
FR (1) FR2396758A1 (fr)
GB (1) GB2000772B (fr)
IT (1) IT1192260B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1193467B (it) * 1978-01-26 1988-07-08 Simes Carbammati di omolisergoli (8 beta-idrossietilergoline)
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline
US4683313A (en) * 1985-06-24 1987-07-28 Eli Lilly And Company 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
GB8615471D0 (en) * 1986-06-25 1986-07-30 Erba Farmitalia T-butyl ergoline derivatives
DE102007014947B4 (de) * 2007-03-23 2010-05-27 Axxonis Pharma Ag Stabilisierte wässrige Lösungen von Ergolinverbindungen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1429210A (fr) * 1964-04-14 1966-02-18 Farmaceutici Italia Nouveaux dérivés de méthyl.6 et diméthyl.1.6 ergoline, substitués en position 2, et leur procédé de préparation
FR2303548A1 (fr) * 1975-03-14 1976-10-08 Siphar Sa Nouveaux carbamates de 2-halogenoergolines et 2-halogenoergolenes, utiles notamment comme vasodilatateurs, et leur procede de preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1053507A (fr) * 1964-04-14
CH507249A (de) * 1968-05-31 1971-05-15 Sandoz Ag Verfahren zur Herstellung von 2-Brom-a-ergokryptin
US3920664A (en) * 1972-07-21 1975-11-18 Lilly Co Eli D-2-halo-6-alkyl-8-substituted ergolines and related compounds
NL7416120A (nl) * 1973-12-21 1975-06-24 Farmaceutici Italia Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten.
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
HU172649B (hu) * 1975-04-24 1978-11-28 Gyogyszerkutato Intezet Sposob poluchenija novykh biologicheski aktivnykh lizergamidov

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1429210A (fr) * 1964-04-14 1966-02-18 Farmaceutici Italia Nouveaux dérivés de méthyl.6 et diméthyl.1.6 ergoline, substitués en position 2, et leur procédé de préparation
FR2303548A1 (fr) * 1975-03-14 1976-10-08 Siphar Sa Nouveaux carbamates de 2-halogenoergolines et 2-halogenoergolenes, utiles notamment comme vasodilatateurs, et leur procede de preparation

Also Published As

Publication number Publication date
JPS6225149B2 (fr) 1987-06-01
US4197299A (en) 1980-04-08
FR2396758B1 (fr) 1981-06-26
DE2829471A1 (de) 1979-02-15
DE2829471C2 (fr) 1988-09-22
GB2000772A (en) 1979-01-17
GB2000772B (en) 1982-02-24
IT7823911A0 (it) 1978-05-26
BE868768A (fr) 1978-11-03
IT1192260B (it) 1988-03-31
JPS5414999A (en) 1979-02-03

Similar Documents

Publication Publication Date Title
FR2378521A1 (fr) Derives du carbostyrile, utiles notamment comme stimulants des centres b- adrenorecepteurs, et leur procede de preparation
FR2360587A1 (fr) Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments
FR2421874A1 (fr) Carboxyalkylacylamino-acides utiles comme agents hypotenseurs
FR2358418A1 (fr) Nouveaux polygalactosidosaccharoses sulfates utiles notamment comme inhibiteurs du complement
FR2376147A1 (fr) Prostaglandines bicycliques, utiles notamment comme anti-agglutinants des plaquettes sanguines et leur procede de preparation
FR2391209A1 (fr) Aminoalkyl thiophenes, utiles comme medicaments, leur preparation et compositions en contenant
FR2401135A1 (fr) Nouveaux derives d'aminoalkyl-benzenes et procedes pour leur preparation
FR2392007A1 (fr) 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy-piperidines, leurs derives, leur preparation et leur utilisation comme antidiarrheiques et analgesiques
FR2446283A1 (fr) Phenoxyphenylpiperidines, leur preparation et leurs applications therapeutiques
FR2436149A1 (fr) Nouveaux aminoglucosides, leur preparation et leur application comme medicaments
FR2389623A1 (fr)
FR2363563A1 (fr) Nouveaux derives de 1-acyloxymethyl-5-fluorouracile utiles notamment comme agents antitumoraux, et leur procede de preparation
FR2423485A1 (fr) Nouvelles 1,3-diaryl-2-imino-imidazolidines et 1,3-diaryl-2-imino-hexahydro-pyrimidines substituees, procedes de preparation de ces composes et medicaments les contenant
FR2396758A1 (fr) Nouveaux 2-thioethers d'ergoline et leurs sulfoxydes, utiles notamment comme bloqueurs des centres adrenergiques a et leurs procedes de preparation
FR2403994A1 (fr) Nouvelles 1-(2-chloroethyl)-1-nitrosourees utiles notamment comme agents antitumoraux et leur procede de preparation
FR2395994A1 (fr) Nouveaux derives d'aminoacides a-acetyleniques et leur utilisation therapeutique
FR2401935A1 (fr) Nouveaux 25-alkylcholesterols utiles notamment comme hypocholesterolemiants et leur procede de preparation
FR2422638A1 (fr) Nouveaux derives de 3,3-dichloro-2-azetidinone, utiles notamment comme agents anti-inflammatoires
FR2445838A1 (fr) Nouveaux 1a,3b-dihydroxy-5-steroides
FR2426690A2 (fr) Composes de rifamycine
FR2401922A1 (fr) Picolylamides d'acides 4-hydroxy-isophtaliques substitues, leur preparation et leurs utilisations therapeutiques
FR2446833A1 (fr) Octahydro-2h-pyrrolo(3,4-g)quinoleines et leur utilisation therapeutiques
FR2373514A1 (fr) Derives d'ammonium quaternaire de l'adamantane utiles notamment comme agents antimicrobiens et leur procede de preparation
FR2429786A1 (fr) Sulfonyl-urees, leurs procedes de preparation et leur application en therapeutique
FR2360305A1 (fr) Nouveaux 2,3-alkylene bis (oxy)benzamides substitues, leurs derives et leurs procedes de preparation

Legal Events

Date Code Title Description
ST Notification of lapse