FR2399835A1 - Procede de preparation de microcapsules contenant un produit pharmaceutique - Google Patents

Procede de preparation de microcapsules contenant un produit pharmaceutique

Info

Publication number
FR2399835A1
FR2399835A1 FR7823573A FR7823573A FR2399835A1 FR 2399835 A1 FR2399835 A1 FR 2399835A1 FR 7823573 A FR7823573 A FR 7823573A FR 7823573 A FR7823573 A FR 7823573A FR 2399835 A1 FR2399835 A1 FR 2399835A1
Authority
FR
France
Prior art keywords
microcapsules containing
pharmaceutical product
preparing microcapsules
polyisobutylene
phase separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7823573A
Other languages
English (en)
Other versions
FR2399835B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of FR2399835A1 publication Critical patent/FR2399835A1/fr
Application granted granted Critical
Publication of FR2399835B1 publication Critical patent/FR2399835B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention a pour objet un procédé de préparation de microcapsules contenant un produit pharmaceutique ou médicament, par séparation de phases liquide-liquide, suivant lequel on utilise, comme agent formateur de paroi, de l'éthylcelluose ayant une teneur pondérale en éthoxy d'environ 48 à 49,5 % et, comme agent inducteur de la separation des phases, du polyisobutylène, lesdits éthyl cellulose et/ou polyisobutylène étant utilisés sous la forme d'un mélange de deux constituants présentant des masses moléculaires moyennes différentes.
FR7823573A 1977-08-11 1978-08-10 Procede de preparation de microcapsules contenant un produit pharmaceutique Granted FR2399835A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9674977A JPS5432614A (en) 1977-08-11 1977-08-11 Preparation of microcapsules containing pharmaceuticals

Publications (2)

Publication Number Publication Date
FR2399835A1 true FR2399835A1 (fr) 1979-03-09
FR2399835B1 FR2399835B1 (fr) 1981-07-10

Family

ID=14173315

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7823573A Granted FR2399835A1 (fr) 1977-08-11 1978-08-10 Procede de preparation de microcapsules contenant un produit pharmaceutique

Country Status (7)

Country Link
US (1) US4218333A (fr)
JP (1) JPS5432614A (fr)
CH (1) CH638398A5 (fr)
DE (1) DE2834373C2 (fr)
FR (1) FR2399835A1 (fr)
GB (1) GB2002318B (fr)
IT (1) IT1107850B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447192A1 (fr) * 1979-01-25 1980-08-22 Adria Lab Inc Forme galenique a liberation prolongee d'indoprofene
FR2468364A1 (fr) * 1979-10-31 1981-05-08 Tanabe Seiyaku Co Procede de preparation de microcapsules d'ethylcellulose contenant un compose pharmaceutiquement actif

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56152739A (en) * 1980-04-25 1981-11-26 Tanabe Seiyaku Co Ltd Production of microcapsule
JPS57197214A (en) * 1981-05-29 1982-12-03 Tanabe Seiyaku Co Ltd Rapid-releasing microcapsule and its preparation
JPS5858146A (ja) * 1981-10-05 1983-04-06 Tanabe Seiyaku Co Ltd 速放性マイクロカプセル
JPS5916821A (ja) * 1982-07-16 1984-01-28 Tanabe Seiyaku Co Ltd 非凝集性マイクロカプセルの製法
CH669506A5 (en) * 1986-01-13 1989-03-31 Hugo Degen Oscillating and reclining furniture
HU201869B (en) * 1988-12-30 1991-01-28 Egyt Gyogyszervegyeszeti Gyar Process for producing microcapsules of quick dissolving active component
JP2017522299A (ja) * 2014-06-30 2017-08-10 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 口腔ケア活性剤のカプセル化

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1419650A1 (de) * 1960-03-09 1969-01-30 Ncr Co Verfahren zur Herstellung sehr kleiner,feste Teilchen enthaltender Kapseln
DE1519848A1 (de) * 1965-08-18 1969-07-10 Ncr Co Verfahren zur Herstellung sehr kleiner Polymerkapseln
FR2084199A5 (fr) * 1970-03-04 1971-12-17 Bayer Ag
FR2206129A1 (fr) * 1972-07-31 1974-06-07 Merck & Co Inc
JPS5255817A (en) * 1975-10-31 1977-05-07 Sony Corp Time error difference correction system of video signal reproduction u nit

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB906422A (en) * 1958-05-02 1962-09-19 Wellcome Found Improvements in and relating to prolonged acting pharmaceutical preparations
US3173878A (en) * 1960-02-26 1965-03-16 Ibm Process of making microcapsules
US3155590A (en) * 1962-08-02 1964-11-03 Ncr Co Encapsulation process and its product
US3341416A (en) * 1963-12-11 1967-09-12 Ncr Co Encapsulation of aspirin in ethylcellulose and its product
US3623997A (en) * 1966-06-06 1971-11-30 Ncr Co Wall-sealing treatment for minute capsules and minute capsules having walls of sealed polymeric material
US3557279A (en) * 1969-06-12 1971-01-19 Merck & Co Inc Microencapsulation form of an anti-inflammatory drug
US4123382A (en) * 1973-05-25 1978-10-31 Merck & Co., Inc. Method of microencapsulation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1419650A1 (de) * 1960-03-09 1969-01-30 Ncr Co Verfahren zur Herstellung sehr kleiner,feste Teilchen enthaltender Kapseln
DE1519848A1 (de) * 1965-08-18 1969-07-10 Ncr Co Verfahren zur Herstellung sehr kleiner Polymerkapseln
FR2084199A5 (fr) * 1970-03-04 1971-12-17 Bayer Ag
FR2206129A1 (fr) * 1972-07-31 1974-06-07 Merck & Co Inc
JPS5255817A (en) * 1975-10-31 1977-05-07 Sony Corp Time error difference correction system of video signal reproduction u nit

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447192A1 (fr) * 1979-01-25 1980-08-22 Adria Lab Inc Forme galenique a liberation prolongee d'indoprofene
FR2468364A1 (fr) * 1979-10-31 1981-05-08 Tanabe Seiyaku Co Procede de preparation de microcapsules d'ethylcellulose contenant un compose pharmaceutiquement actif

Also Published As

Publication number Publication date
DE2834373A1 (de) 1979-02-22
GB2002318A (en) 1979-02-21
GB2002318B (en) 1982-02-10
FR2399835B1 (fr) 1981-07-10
US4218333A (en) 1980-08-19
DE2834373C2 (de) 1985-09-26
JPS5432614A (en) 1979-03-10
IT1107850B (it) 1985-12-02
IT7868892A0 (it) 1978-08-10
CH638398A5 (de) 1983-09-30
JPS5632294B2 (fr) 1981-07-27

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Legal Events

Date Code Title Description
ST Notification of lapse