FR2393801A1 - Nouveaux 9-hydroxyhexahydrodibenzo(b,d)pyranes, leurs derives substitues en position 1, leur procede de preparation et medicament les contenant - Google Patents
Nouveaux 9-hydroxyhexahydrodibenzo(b,d)pyranes, leurs derives substitues en position 1, leur procede de preparation et medicament les contenantInfo
- Publication number
- FR2393801A1 FR2393801A1 FR787816894A FR7816894A FR2393801A1 FR 2393801 A1 FR2393801 A1 FR 2393801A1 FR 787816894 A FR787816894 A FR 787816894A FR 7816894 A FR7816894 A FR 7816894A FR 2393801 A1 FR2393801 A1 FR 2393801A1
- Authority
- FR
- France
- Prior art keywords
- hydroxyhexahydrodibenzo
- pyranes
- new
- preparation process
- product containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
- C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
L'invention a trait au domaine de la chimie médicale. Elle concerne des 9-hydroxyhexahydrodibenzo Øb,dõ pyranes, des 9-hydroxyhexahydrodibenzoØb,dõpyranes substitués en position 1 dont le substituant est un atome d'hydrogène ou un groupe méthyle, hydroxyméthyle, formyle, carboxy, carbamyle, amino, mono-ou dialkylamino, alcanoylamino, phénylalkylsulfamido ou alkylsulfamido, et les 9-cétones correspondantes. Les composés de l'invention sont doués de propriétés analgésiques et tranquillisantes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/804,306 US4118559A (en) | 1977-06-07 | 1977-06-07 | 9-Hydroxyhexahydrodibenzo[O,d]pyrans, 1-substituted-9-hydroxyhexahydrodibenzo[b,d]pyrans and intermediates therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2393801A1 true FR2393801A1 (fr) | 1979-01-05 |
FR2393801B1 FR2393801B1 (fr) | 1980-11-07 |
Family
ID=25188658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR787816894A Granted FR2393801A1 (fr) | 1977-06-07 | 1978-06-06 | Nouveaux 9-hydroxyhexahydrodibenzo(b,d)pyranes, leurs derives substitues en position 1, leur procede de preparation et medicament les contenant |
Country Status (10)
Country | Link |
---|---|
US (1) | US4118559A (fr) |
JP (4) | JPS543075A (fr) |
BE (1) | BE867858A (fr) |
DE (1) | DE2824987A1 (fr) |
DK (1) | DK251178A (fr) |
FR (1) | FR2393801A1 (fr) |
GB (2) | GB2067184B (fr) |
IT (1) | IT1110481B (fr) |
LU (1) | LU79767A1 (fr) |
NL (1) | NL7806189A (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4165323A (en) * | 1977-06-07 | 1979-08-21 | Pfizer Inc. | 9-Hydroxyhexahydrodibenzo[b,d]pyrans, 1-substituted-9-hydroxyhexahydrodibenzo[b,d]pyrans and intermediates therefor |
US4243674A (en) * | 1978-06-12 | 1981-01-06 | Pfizer Inc. | 9-Hydroxydibenzo[b,d]pyrans and intermediates therefore |
US4340737A (en) * | 1979-05-29 | 1982-07-20 | Pfizer Inc. | 9-Hydroxyoctahydrobenzo[C]quinolines and intermediates therefor |
US4405626A (en) * | 1980-10-03 | 1983-09-20 | Pfizer Inc. | 9-Hydroxyoctahydrobenzo(c)quinolines analgesic compositions containing them and processes for producing analgesic with them |
US4400385A (en) * | 1980-10-03 | 1983-08-23 | Pfizer Inc. | 9-Hydroxyoctahydrobenzo [c]quinolines, analgesic compositions containing them and processes for producing analgesia with them |
US4454144A (en) * | 1982-06-21 | 1984-06-12 | Pfizer Inc. | Substituted dibenzo[b,d]pyran analgesics |
US4681954A (en) * | 1985-10-07 | 1987-07-21 | Pennwalt Corporation | 7,8,9,10-tetrahydro-6-oxo-6H-dibenzo(b,d)pyranyloxy-propanes |
US4647674A (en) * | 1985-10-07 | 1987-03-03 | Pennwalt Corporation | Bis-(dibenzo[b,d]pyranyloxy) propanes |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4033845A (en) * | 1975-11-20 | 1977-07-05 | Warner-Lambert Company | [2-(4-Oxo-4H-1-benzopyran-2-yl)ethenyl]benzonitriles and benzoic acids |
-
1977
- 1977-06-07 US US05/804,306 patent/US4118559A/en not_active Expired - Lifetime
-
1978
- 1978-06-05 LU LU79767A patent/LU79767A1/fr unknown
- 1978-06-06 DK DK251178A patent/DK251178A/da unknown
- 1978-06-06 BE BE188351A patent/BE867858A/fr unknown
- 1978-06-06 GB GB8027390A patent/GB2067184B/en not_active Expired
- 1978-06-06 IT IT24269/78A patent/IT1110481B/it active
- 1978-06-06 GB GB7826430A patent/GB2000761B/en not_active Expired
- 1978-06-06 FR FR787816894A patent/FR2393801A1/fr active Granted
- 1978-06-07 NL NL7806189A patent/NL7806189A/xx not_active Application Discontinuation
- 1978-06-07 DE DE19782824987 patent/DE2824987A1/de not_active Withdrawn
- 1978-06-07 JP JP6872778A patent/JPS543075A/ja active Granted
-
1979
- 1979-05-29 JP JP6671579A patent/JPS54163580A/ja active Pending
- 1979-05-29 JP JP6671779A patent/JPS54163581A/ja active Pending
- 1979-05-29 JP JP6671679A patent/JPS5511571A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK251178A (da) | 1978-12-08 |
GB2067184A (en) | 1981-07-22 |
GB2000761B (en) | 1982-05-26 |
US4118559A (en) | 1978-10-03 |
NL7806189A (nl) | 1978-12-11 |
JPS54163580A (en) | 1979-12-26 |
FR2393801B1 (fr) | 1980-11-07 |
DE2824987A1 (de) | 1978-12-14 |
BE867858A (fr) | 1978-12-06 |
JPS5511571A (en) | 1980-01-26 |
JPS5735914B2 (fr) | 1982-07-31 |
JPS54163581A (en) | 1979-12-26 |
JPS543075A (en) | 1979-01-11 |
IT1110481B (it) | 1985-12-23 |
LU79767A1 (fr) | 1980-01-22 |
IT7824269A0 (it) | 1978-06-06 |
GB2000761A (en) | 1979-01-17 |
GB2067184B (en) | 1982-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |