FR2380780A2 - Psychotropic medicaments - comprising 5-hydroxymethyl-3-phenyl-2-oxazolidone derivs. - Google Patents

Psychotropic medicaments - comprising 5-hydroxymethyl-3-phenyl-2-oxazolidone derivs.

Info

Publication number
FR2380780A2
FR2380780A2 FR7718075A FR7718075A FR2380780A2 FR 2380780 A2 FR2380780 A2 FR 2380780A2 FR 7718075 A FR7718075 A FR 7718075A FR 7718075 A FR7718075 A FR 7718075A FR 2380780 A2 FR2380780 A2 FR 2380780A2
Authority
FR
France
Prior art keywords
hydroxymethyl
phenyl
derivs
oxazolidone
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7718075A
Other languages
French (fr)
Other versions
FR2380780B2 (en
Inventor
Philippe Dostert
Colette Douzon
Guy Bourgery
Claude Gouret
Gisele Mocquet
Alain Coston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH219177A external-priority patent/CH618975A5/fr
Application filed by Delalande SA filed Critical Delalande SA
Publication of FR2380780A2 publication Critical patent/FR2380780A2/en
Application granted granted Critical
Publication of FR2380780B2 publication Critical patent/FR2380780B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Abstract

Medicaments comprising 5-hydroxymethyl-3-phenyl-2-oxazolidones of formula (I) are claimed. (where R is NO2, 1-3C alkoxy (but not p-OMe), 1-3C alkylthio, 2-4C acyl, Br, or several 1-4C alkyl gps.). Cpds. (I) are 5-hydroxytryptophan potentiators and reserpine antagonists useful as psychotropic agents. Some have higher activity and lower toxicity than toloxatone. Cpds. (I) and their prepn. are described in the Parent Patent. They can be administered orally as tablets, dragees or capsules in a daily dose of 500 mg.
FR7718075A 1977-02-22 1977-06-13 Psychotropic medicaments - comprising 5-hydroxymethyl-3-phenyl-2-oxazolidone derivs. Granted FR2380780A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH219177A CH618975A5 (en) 1976-03-01 1977-02-22

Publications (2)

Publication Number Publication Date
FR2380780A2 true FR2380780A2 (en) 1978-09-15
FR2380780B2 FR2380780B2 (en) 1981-05-29

Family

ID=4228019

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7718075A Granted FR2380780A2 (en) 1977-02-22 1977-06-13 Psychotropic medicaments - comprising 5-hydroxymethyl-3-phenyl-2-oxazolidone derivs.
FR7726104A Granted FR2381038A2 (en) 1977-02-22 1977-08-26 NEW DERIVATIVES OF CARBAMOYLOXYMETHYL-5 OXAZOLIDINONE-2, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
FR7726105A Granted FR2381037A2 (en) 1977-02-22 1977-08-26 NEW HYDROXYMETHYL-5 OXAZOLIDINONES-2, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR7726104A Granted FR2381038A2 (en) 1977-02-22 1977-08-26 NEW DERIVATIVES OF CARBAMOYLOXYMETHYL-5 OXAZOLIDINONE-2, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
FR7726105A Granted FR2381037A2 (en) 1977-02-22 1977-08-26 NEW HYDROXYMETHYL-5 OXAZOLIDINONES-2, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Country Status (1)

Country Link
FR (3) FR2380780A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4413001A (en) * 1978-06-09 1983-11-01 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4340606A (en) 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2528046B1 (en) * 1982-06-08 1985-06-21 Delalande Sa OPTICALLY ACTIVE OXAZOLIDINONE-2 N-ARYLATED DERIVATIVES, SPECIFIC AND REVERSIBLE INHIBITORS OF TYPE B MONOAMINE OXYDASE AND PROCESS FOR THEIR PREPARATION
TW286317B (en) * 1993-12-13 1996-09-21 Hoffmann La Roche
HUP9901979A3 (en) * 1995-09-01 2000-03-28 Upjohn Co Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings and pharmaceutical compositions containing the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035024A1 (en) * 1969-03-18 1970-12-18 Delalande Sa

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035024A1 (en) * 1969-03-18 1970-12-18 Delalande Sa

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4413001A (en) * 1978-06-09 1983-11-01 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones

Also Published As

Publication number Publication date
FR2380780B2 (en) 1981-05-29
FR2381038A2 (en) 1978-09-15
FR2381037B2 (en) 1981-05-29
FR2381038B2 (en) 1980-07-18
FR2381037A2 (en) 1978-09-15

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