FR2378024A1 - Nouvelle propylamine substituee, obtention et application - Google Patents

Nouvelle propylamine substituee, obtention et application

Info

Publication number
FR2378024A1
FR2378024A1 FR7702058A FR7702058A FR2378024A1 FR 2378024 A1 FR2378024 A1 FR 2378024A1 FR 7702058 A FR7702058 A FR 7702058A FR 7702058 A FR7702058 A FR 7702058A FR 2378024 A1 FR2378024 A1 FR 2378024A1
Authority
FR
France
Prior art keywords
obtaining
applying
new substituted
propylamine
substituted propylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7702058A
Other languages
English (en)
French (fr)
Other versions
FR2378024B1 (xx
Inventor
R Y Mauvernay
N Busch
J Simond
A Monteil
J Moleyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Priority to FR7702058A priority Critical patent/FR2378024A1/fr
Priority to JP11797777A priority patent/JPS5392764A/ja
Priority to CH27378A priority patent/CH628889A5/fr
Priority to GB1506/78A priority patent/GB1595031A/en
Priority to IL53816A priority patent/IL53816A0/xx
Priority to GR55207A priority patent/GR64868B7/el
Priority to NLAANVRAGE7800753,A priority patent/NL189258C/xx
Priority to PT67556A priority patent/PT67556B/pt
Priority to ES466237A priority patent/ES466237A1/es
Priority to AU32660/78A priority patent/AU516479B2/en
Priority to BE184554A priority patent/BE863214A/xx
Priority to ZA00780426A priority patent/ZA78426B/xx
Priority to DE2802864A priority patent/DE2802864C2/de
Publication of FR2378024A1 publication Critical patent/FR2378024A1/fr
Application granted granted Critical
Publication of FR2378024B1 publication Critical patent/FR2378024B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7702058A 1973-02-28 1977-01-25 Nouvelle propylamine substituee, obtention et application Granted FR2378024A1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR7702058A FR2378024A1 (fr) 1977-01-25 1977-01-25 Nouvelle propylamine substituee, obtention et application
JP11797777A JPS5392764A (en) 1977-01-25 1977-10-03 Novel substituted propylamine and method for its production
CH27378A CH628889A5 (en) 1977-01-25 1978-01-11 Substituted propylamine, process for its preparation and pharmaceutical composition containing this compound
GB1506/78A GB1595031A (en) 1977-01-25 1978-01-13 3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzyl propylamine and its salts
IL53816A IL53816A0 (en) 1977-01-25 1978-01-16 A new substituted propylamine, its preparation and pharmaceutical compositions containing it
GR55207A GR64868B7 (en) 1973-02-28 1978-01-19 Method for the preparation of novel substituted propilamine
NLAANVRAGE7800753,A NL189258C (nl) 1977-01-25 1978-01-20 Zout van 3-isobutoxy-2-pyrrolidino-n-fenyl-n-benzyl-propylamine met cardiovasculaire eigenschappen, alsmede geneesmiddel dat dit zout bevat.
PT67556A PT67556B (fr) 1977-01-25 1978-01-20 Procede d'obtention d'une nouvelle propylamine substituee
ES466237A ES466237A1 (es) 1977-01-25 1978-01-21 Procedimiento para la obtencion de una nueva propilamina sustituida.
AU32660/78A AU516479B2 (en) 1977-01-25 1978-01-23 Process for preparing 3-isobutoxy 2-pyrrolidino n-phenyl n-benzyl propylamine
BE184554A BE863214A (fr) 1977-01-25 1978-01-23 Nouvelle propylamine substituee, obtention et application
ZA00780426A ZA78426B (en) 1977-01-25 1978-01-24 Substituted propylamine and a process for obtaining same
DE2802864A DE2802864C2 (de) 1977-01-25 1978-01-24 Verfahren zur Herstellung von 3-Isobutoxy-2-pyrrolidino-N-phenyl-N-benzylpropylamin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7702058A FR2378024A1 (fr) 1977-01-25 1977-01-25 Nouvelle propylamine substituee, obtention et application

Publications (2)

Publication Number Publication Date
FR2378024A1 true FR2378024A1 (fr) 1978-08-18
FR2378024B1 FR2378024B1 (xx) 1979-05-11

Family

ID=9185890

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7702058A Granted FR2378024A1 (fr) 1973-02-28 1977-01-25 Nouvelle propylamine substituee, obtention et application

Country Status (12)

Country Link
JP (1) JPS5392764A (xx)
AU (1) AU516479B2 (xx)
BE (1) BE863214A (xx)
CH (1) CH628889A5 (xx)
DE (1) DE2802864C2 (xx)
ES (1) ES466237A1 (xx)
FR (1) FR2378024A1 (xx)
GB (1) GB1595031A (xx)
IL (1) IL53816A0 (xx)
NL (1) NL189258C (xx)
PT (1) PT67556B (xx)
ZA (1) ZA78426B (xx)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138684A2 (fr) * 1983-09-27 1985-04-24 Riom Laboratoires- C.E.R.M. "R.L.-Cerm" - (S.A.) 2-(N-pyrrolidino)-3-isobutoxy-N-phenyl substitué N-benzyl propylamines, leur préparation et leur application pharmaceutique
FR2558160A1 (fr) * 1984-01-18 1985-07-19 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyrimidinyl ou -pyrazinyl propylamines, leur preparation et leur application en therapeutique
FR2558161A1 (fr) * 1984-01-18 1985-07-19 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino) n-furylmethyl ou n-thienylmethyl n-pyridyl propylamines, leur preparation et leur application en therapeutique
FR2558159A1 (fr) * 1984-01-18 1985-07-19 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyridyl-n-arylmethyl-propylamines, leur preparation et leur application en therapeutique
EP0303181A2 (de) * 1987-08-11 1989-02-15 Roche Diagnostics GmbH 1,2-Diamino-Verbindungen, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002274A1 (en) * 1981-12-28 1983-07-07 Carter Wallace Synthesis of 1-(3-isobutoxy-2-(phenylbenzyl)-amino)-propyl-pyrrolidino hydrochloride
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative
DE3468684D1 (de) * 1983-11-11 1988-02-18 Akzo Nv Ether of n-propanolamine derivative
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JP2678758B2 (ja) * 1988-02-16 1997-11-17 興和株式会社 新規なプロパン誘導体
WO2016098128A1 (en) * 2014-12-16 2016-06-23 Council Of Scientific & Industrial Research Process for the preparation of bepridil

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2174655A1 (xx) * 1972-03-06 1973-10-19 Mauvernay Ctre Rech

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2174655A1 (xx) * 1972-03-06 1973-10-19 Mauvernay Ctre Rech

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138684A2 (fr) * 1983-09-27 1985-04-24 Riom Laboratoires- C.E.R.M. "R.L.-Cerm" - (S.A.) 2-(N-pyrrolidino)-3-isobutoxy-N-phenyl substitué N-benzyl propylamines, leur préparation et leur application pharmaceutique
EP0138684A3 (en) * 1983-09-27 1985-06-19 Riom Laboratoires- C.E.R.M. "R.L.-Cerm" - (S.A.) 2-(n-pyrrolidino)-3-isobutoxy-n-phenyl-substituted n-benzylpropyl amines, their preparation and their pharmaceutical use
FR2558160A1 (fr) * 1984-01-18 1985-07-19 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyrimidinyl ou -pyrazinyl propylamines, leur preparation et leur application en therapeutique
FR2558161A1 (fr) * 1984-01-18 1985-07-19 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino) n-furylmethyl ou n-thienylmethyl n-pyridyl propylamines, leur preparation et leur application en therapeutique
FR2558159A1 (fr) * 1984-01-18 1985-07-19 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyridyl-n-arylmethyl-propylamines, leur preparation et leur application en therapeutique
EP0149583A2 (fr) * 1984-01-18 1985-07-24 Riom Laboratoires- C.E.R.M. "R.L.-Cerm" - (S.A.) 3-Alkoxy-2(N-pyrrolidino)-N-pyridyl-N-furyl (ou thienyl)-methyl-propylamines, leur préparation et les compositions pharmaceutiques les contenant
EP0151062A2 (fr) * 1984-01-18 1985-08-07 Riom Laboratoires- C.E.R.M. "R.L.-Cerm" - (S.A.) 3-Alkoxy-2-(N-pyrrolidino)-N-pyrimidinyl ou N-pyrazinyl-propylamines, leur préparation et les compositions pharmaceutiques les contenant
EP0149583A3 (fr) * 1984-01-18 1985-08-07 Riom Laboratoires- C.E.R.M. "R.L.-Cerm" - (S.A.) 3-Alkoxy-2(N-pyrrolidino)-N-pyridyl-N-furyl (ou thienyl)-methyl-propylamines, leur préparation et les compositions pharmaceutiques les contenant
EP0151062A3 (fr) * 1984-01-18 1985-08-21 Riom Laboratoires- C.E.R.M. "R.L.-Cerm" - (S.A.) 3-Alkoxy-2-(N-pyrrolidino)-N-pyrimidinyl ou N-pyrazinyl-propylamines, leur préparation et les compositions pharmaceutiques les contenant
EP0303181A2 (de) * 1987-08-11 1989-02-15 Roche Diagnostics GmbH 1,2-Diamino-Verbindungen, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
EP0303181A3 (de) * 1987-08-11 1991-09-04 Roche Diagnostics GmbH 1,2-Diamino-Verbindungen, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Also Published As

Publication number Publication date
PT67556A (fr) 1978-02-01
NL7800753A (nl) 1978-07-27
NL189258C (nl) 1993-02-16
IL53816A0 (en) 1978-04-30
ZA78426B (en) 1979-01-31
AU3266078A (en) 1979-08-02
DE2802864C2 (de) 1982-12-09
GB1595031A (en) 1981-08-05
FR2378024B1 (xx) 1979-05-11
JPS5429493B2 (xx) 1979-09-25
NL189258B (nl) 1992-09-16
AU516479B2 (en) 1981-06-04
JPS5392764A (en) 1978-08-15
ES466237A1 (es) 1978-10-16
PT67556B (fr) 1979-06-18
DE2802864A1 (de) 1978-07-27
CH628889A5 (en) 1982-03-31
BE863214A (fr) 1978-07-24

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