NL189258B - Zout van 3-isobutoxy-2-pyrrolidino-n-fenyl-n-benzyl-propylamine met cardiovasculaire eigenschappen, alsmede geneesmiddel dat dit zout bevat. - Google Patents

Zout van 3-isobutoxy-2-pyrrolidino-n-fenyl-n-benzyl-propylamine met cardiovasculaire eigenschappen, alsmede geneesmiddel dat dit zout bevat.

Info

Publication number
NL189258B
NL189258B NLAANVRAGE7800753,A NL7800753A NL189258B NL 189258 B NL189258 B NL 189258B NL 7800753 A NL7800753 A NL 7800753A NL 189258 B NL189258 B NL 189258B
Authority
NL
Netherlands
Prior art keywords
salt
pyrrolidino
isobutoxy
propylamine
benzyl
Prior art date
Application number
NLAANVRAGE7800753,A
Other languages
English (en)
Other versions
NL7800753A (nl
NL189258C (nl
Original Assignee
Cerm Cent Europ Rech Mauvernay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerm Cent Europ Rech Mauvernay filed Critical Cerm Cent Europ Rech Mauvernay
Publication of NL7800753A publication Critical patent/NL7800753A/nl
Publication of NL189258B publication Critical patent/NL189258B/nl
Application granted granted Critical
Publication of NL189258C publication Critical patent/NL189258C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NLAANVRAGE7800753,A 1977-01-25 1978-01-20 Zout van 3-isobutoxy-2-pyrrolidino-n-fenyl-n-benzyl-propylamine met cardiovasculaire eigenschappen, alsmede geneesmiddel dat dit zout bevat. NL189258C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7702058A FR2378024A1 (fr) 1977-01-25 1977-01-25 Nouvelle propylamine substituee, obtention et application

Publications (3)

Publication Number Publication Date
NL7800753A NL7800753A (nl) 1978-07-27
NL189258B true NL189258B (nl) 1992-09-16
NL189258C NL189258C (nl) 1993-02-16

Family

ID=9185890

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7800753,A NL189258C (nl) 1977-01-25 1978-01-20 Zout van 3-isobutoxy-2-pyrrolidino-n-fenyl-n-benzyl-propylamine met cardiovasculaire eigenschappen, alsmede geneesmiddel dat dit zout bevat.

Country Status (12)

Country Link
JP (1) JPS5392764A (nl)
AU (1) AU516479B2 (nl)
BE (1) BE863214A (nl)
CH (1) CH628889A5 (nl)
DE (1) DE2802864C2 (nl)
ES (1) ES466237A1 (nl)
FR (1) FR2378024A1 (nl)
GB (1) GB1595031A (nl)
IL (1) IL53816A0 (nl)
NL (1) NL189258C (nl)
PT (1) PT67556B (nl)
ZA (1) ZA78426B (nl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002274A1 (en) * 1981-12-28 1983-07-07 Carter Wallace Synthesis of 1-(3-isobutoxy-2-(phenylbenzyl)-amino)-propyl-pyrrolidino hydrochloride
DK156396C (da) * 1983-09-27 1990-01-08 Cerm Cent Europ Rech Mauvernay 2-(n-pyrrolidino)-3-isobutoxy-n-substituerede phenyl-n-benzyl-propylamin-forbindelser og farmaceutiske midler indeholdende disse
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative
DE3468684D1 (de) * 1983-11-11 1988-02-18 Akzo Nv Ether of n-propanolamine derivative
FR2558161B1 (fr) * 1984-01-18 1987-01-23 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino) n-furylmethyl ou n-thienylmethyl n-pyridyl propylamines, leur preparation et leur application en therapeutique
FR2558160B1 (fr) * 1984-01-18 1986-05-30 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyrimidinyl ou -pyrazinyl propylamines, leur preparation et leur application en therapeutique
FR2558159B1 (fr) * 1984-01-18 1986-06-13 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyridyl-n-arylmethyl-propylamines, leur preparation et leur application en therapeutique
DE3726632A1 (de) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JP2678758B2 (ja) * 1988-02-16 1997-11-17 興和株式会社 新規なプロパン誘導体
WO2016098128A1 (en) * 2014-12-16 2016-06-23 Council Of Scientific & Industrial Research Process for the preparation of bepridil

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795735A (fr) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay Nouvelles ethylenediamines substituees a activite cardiovasculaire

Also Published As

Publication number Publication date
PT67556A (fr) 1978-02-01
NL7800753A (nl) 1978-07-27
FR2378024A1 (fr) 1978-08-18
NL189258C (nl) 1993-02-16
IL53816A0 (en) 1978-04-30
ZA78426B (en) 1979-01-31
AU3266078A (en) 1979-08-02
DE2802864C2 (de) 1982-12-09
GB1595031A (en) 1981-08-05
FR2378024B1 (nl) 1979-05-11
JPS5429493B2 (nl) 1979-09-25
AU516479B2 (en) 1981-06-04
JPS5392764A (en) 1978-08-15
ES466237A1 (es) 1978-10-16
PT67556B (fr) 1979-06-18
DE2802864A1 (de) 1978-07-27
CH628889A5 (en) 1982-03-31
BE863214A (fr) 1978-07-24

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Legal Events

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BB A search report has been drawn up
BC A request for examination has been filed
BC A request for examination has been filed
A85 Still pending on 85-01-01
BV The patent application has lapsed
DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

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