FR2377395A2 - Nouveaux derives de la 11-desoxy prostaglandine f2, leur procede de preparation et leur application comme medicaments - Google Patents
Nouveaux derives de la 11-desoxy prostaglandine f2, leur procede de preparation et leur application comme medicamentsInfo
- Publication number
- FR2377395A2 FR2377395A2 FR7701299A FR7701299A FR2377395A2 FR 2377395 A2 FR2377395 A2 FR 2377395A2 FR 7701299 A FR7701299 A FR 7701299A FR 7701299 A FR7701299 A FR 7701299A FR 2377395 A2 FR2377395 A2 FR 2377395A2
- Authority
- FR
- France
- Prior art keywords
- hypotensives
- smooth
- agents
- prostaglandin analogues
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001077 hypotensive effect Effects 0.000 title abstract 3
- 208000001953 Hypotension Diseases 0.000 title abstract 2
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title abstract 2
- 208000021822 hypotensive Diseases 0.000 title abstract 2
- 239000000130 luteolytic agent Substances 0.000 title abstract 2
- 210000002460 smooth muscle Anatomy 0.000 title abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000012173 estrus Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000002863 oxytocic agent Substances 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Les produits répondant à la formule I du brevet principal dont les noms suivent : L'acide (8RS, 9SR, 12RS, 15 alpha RS) (5Z, 13E) 9,15-dihydroxy 16-Ø3'(5'-chlorolthiényloxyõ 17, 18, 19, 20 tétranor prosta 5,13- diénoïque et son sel de tris(hydroxyméthyl)méthylamine; L'acide (8RS, 9SR, 12RS, 15 beta SR) (5Z, 13E)9,15-dihydroy 16-Ø3'(5'-chlorolthiényloxyõ 17, 18, 19, 20 tétranor prosta 5,13- diénoïque et son sel de tris(hydroxyméthyl)méthylamine; L'acide (8RS, 9SR, 12RS, 150 H alpha RS) (5Z, 13E) 9,15-dihydroxy 16-Ø3'(2'-chloro)thiényloxyõ 17, 18, 19, 20 tétranor prosta 5,13-diénoïque et son sel de tris(hydroxyméthyl)méthyllamine; L'acide (8RS, 9SR, 12RS, 15RS) (5Z, 13E) 9,15-dihydroxy 16-Ø3'-(4'-chloro)thiényloxyõ 17, 18, 19, 20 tétranor prosta 5,13-diénoïque et son sel de tris(hydroxyméthyl)méthylamine; L'acide (8RS, 9SR, 12RS, 15 alpha RS)(5Z, 13E) 9,15-dihydroxy 16-Ø3'-(2'-cyano, 5'-méthyl)thiényoxyõ 17, 18, 19, 20 tétranor prosta 5,13-diénoïque et son sel de tris(hydroxyméthylõméthylamine ; Le sel de tris-(hydroxyméthyõméthylanine de l'acide (8RS, 9SR, 12RS, 15RS) (5Z, 13E) 9,15-dihydroxy 16-Ø3'(1'-thia 2', 5'-diazolyloxy)õ 17, 18, 19, 20 tétranor prosta 5,13-diénoÏque et leurs applications.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7701299A FR2377395A2 (fr) | 1977-01-18 | 1977-01-18 | Nouveaux derives de la 11-desoxy prostaglandine f2, leur procede de preparation et leur application comme medicaments |
SE7704616A SE436037B (sv) | 1976-04-30 | 1977-04-21 | Sett att framstella nya 11-desoxi-prostaglandin-f?712-derivat |
CA277,423A CA1100493A (fr) | 1976-04-30 | 1977-04-29 | Procede de preparation de nouveaux derives de la 11- desoxy prostaglandine f.sub.2 |
NL7704758A NL7704758A (nl) | 1976-04-30 | 1977-04-29 | Werkwijze voor de bereiding van nieuwe ver- bindingen van 11-desoxyprostaglandine f2. |
GB18082/77A GB1538842A (en) | 1976-04-30 | 1977-04-29 | Prostaglandin derivatives |
DK187677A DK187677A (da) | 1976-04-30 | 1977-04-29 | Fremgangsmade til fremstilling af derivater af 11-desoxyprostandin f2. |
CH541177A CH620675A5 (fr) | 1976-04-30 | 1977-04-29 | |
DE19772719244 DE2719244A1 (de) | 1976-04-30 | 1977-04-29 | Neue derivate des 11-desoxy-prostaglandin-f tief 2 , verfahren zu deren herstellung und pharmazeutische zusammensetzungen |
AR267416A AR222627A1 (es) | 1976-04-30 | 1977-04-29 | Procedimiento para la preparacion de los nuevos derivados de acido(8rs,9rs,12rs,15rs)(5z,13e)9,15-dihidroxi 16-sustituido-18,19,20-trinor(o 17,18,19,20-tetranor)prosta 5,13-dienoico e intermediarios para su uso exclusivo en dicho procedimiento |
JP5061277A JPS52148048A (en) | 1976-04-30 | 1977-04-30 | New 111deoxyprostaglandin f2 derivative* process for manufacture and pharmaceutical compositions thereof |
IE885/77A IE45141B1 (en) | 1976-04-30 | 1977-05-02 | Prostaglandin derivatives |
US05/792,563 US4119727A (en) | 1976-04-30 | 1977-05-02 | Novel 11-desoxy-prostaglandin F2 derivatives |
AU24795/77A AU511408B2 (en) | 1976-04-30 | 1977-05-02 | 11-desoxy prostaglandin f2 derivatives |
AT310177A AT355739B (de) | 1976-04-30 | 1977-05-02 | Verfahren zur herstellung neuer derivate des 11-desoxy prostaglandins f2 |
LU77240A LU77240A1 (fr) | 1976-04-30 | 1977-05-03 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7701299A FR2377395A2 (fr) | 1977-01-18 | 1977-01-18 | Nouveaux derives de la 11-desoxy prostaglandine f2, leur procede de preparation et leur application comme medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2377395A2 true FR2377395A2 (fr) | 1978-08-11 |
FR2377395B2 FR2377395B2 (fr) | 1982-09-17 |
Family
ID=9185611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7701299A Granted FR2377395A2 (fr) | 1976-04-30 | 1977-01-18 | Nouveaux derives de la 11-desoxy prostaglandine f2, leur procede de preparation et leur application comme medicaments |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2377395A2 (fr) |
-
1977
- 1977-01-18 FR FR7701299A patent/FR2377395A2/fr active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2377395B2 (fr) | 1982-09-17 |
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