FR2372629A1 - Nouvel antibiotique et son procede de preparation - Google Patents

Nouvel antibiotique et son procede de preparation

Info

Publication number
FR2372629A1
FR2372629A1 FR7614782A FR7614782A FR2372629A1 FR 2372629 A1 FR2372629 A1 FR 2372629A1 FR 7614782 A FR7614782 A FR 7614782A FR 7614782 A FR7614782 A FR 7614782A FR 2372629 A1 FR2372629 A1 FR 2372629A1
Authority
FR
France
Prior art keywords
antibiotic
components
lysolipine
derivatives
nutrient solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7614782A
Other languages
English (en)
Other versions
FR2372629B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH647775A external-priority patent/CH603791A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2372629A1 publication Critical patent/FR2372629A1/fr
Application granted granted Critical
Publication of FR2372629B1 publication Critical patent/FR2372629B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1. L'invention concerne un nouvel antibiotique insoluble dans l'eau, la lysolipine, qui se trouve sous forme de ses composants X et I ou de mélanges de ces composants, et les dérivés de l'antibiotique ainsi que les préparations qui contiennent ces composés et un procédé de preparation de ces substances. 2. Conformément au procédé de l'invention, on effectue une culture aérobie de la souche Streptomyces violaceoniger Tü 96 ou un mutant formant la lysolipine dans une solution nutritive aqueuse contenant une source de carbone et d'azote ainsi que des sels inorganiques, jusqu'à ce que la solution nutritive présente une nette activité antibiotique, on isole la lysolipine de cette dernière et, si on le désire, on la sépare en ses composants et/ou on la transforme en dérivés. 3. Application en tant que médicament antibiotique.
FR7614782A 1975-05-20 1976-05-17 Nouvel antibiotique et son procede de preparation Granted FR2372629A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH647775A CH603791A5 (en) 1975-05-20 1975-05-20 Antibacterial lysolipins and lysolipin I di-O-acetate
CH422876 1976-04-05

Publications (2)

Publication Number Publication Date
FR2372629A1 true FR2372629A1 (fr) 1978-06-30
FR2372629B1 FR2372629B1 (fr) 1979-03-23

Family

ID=25694966

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7614782A Granted FR2372629A1 (fr) 1975-05-20 1976-05-17 Nouvel antibiotique et son procede de preparation

Country Status (12)

Country Link
US (1) US4277478A (fr)
JP (1) JPS51142597A (fr)
AU (1) AU508077B2 (fr)
CA (1) CA1079213A (fr)
DE (1) DE2621690A1 (fr)
DK (1) DK143907C (fr)
FR (1) FR2372629A1 (fr)
GB (1) GB1550700A (fr)
GR (1) GR59336B (fr)
IL (1) IL49591A (fr)
NL (1) NL7605303A (fr)
NZ (1) NZ180898A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650802A (en) * 1984-03-26 1987-03-17 American Cyanamid Company Methods and compositions for treating protozoal infections with a novel antibiotic
US4649143A (en) * 1984-03-26 1987-03-10 American Cyanamid Company Methods and compositions for treating protozoal infections with a novel antibiotic
EP0156193B1 (fr) * 1984-03-26 1990-12-27 American Cyanamid Company Composés et compositions pour le traitement d'infections protozoiques avec un antibiotique
US5087567A (en) * 1990-01-12 1992-02-11 Bristol-Myers Squibb Company Antitumor antibiotic BMY-42428
WO2002027010A1 (fr) * 2000-09-29 2002-04-04 Taisho Pharmaceutical Co., Ltd. Compose a base de xanthone
WO2006032232A2 (fr) * 2004-09-24 2006-03-30 Combinature Biopharm Ag Nouvelle batterie de genes de biosynthese de lysolipine
DE102006002427A1 (de) * 2006-01-09 2007-07-12 Combinature Biopharm Ag Neue Lysolipin Derivate

Also Published As

Publication number Publication date
AU1408076A (en) 1977-11-24
DK221476A (da) 1976-11-21
DK143907C (da) 1982-05-24
IL49591A0 (en) 1976-07-30
IL49591A (en) 1979-11-30
AU508077B2 (en) 1980-03-06
FR2372629B1 (fr) 1979-03-23
DK143907B (da) 1981-10-26
CA1079213A (fr) 1980-06-10
GB1550700A (en) 1979-08-15
DE2621690A1 (de) 1976-12-09
GR59336B (en) 1977-12-14
NZ180898A (en) 1979-10-25
JPS51142597A (en) 1976-12-08
NL7605303A (nl) 1976-11-23
US4277478A (en) 1981-07-07

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Legal Events

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