FR2371443A1 - Composes chimiques utiles en particulier comme agents d'evacuation uterine, et procedes de preparation - Google Patents
Composes chimiques utiles en particulier comme agents d'evacuation uterine, et procedes de preparationInfo
- Publication number
- FR2371443A1 FR2371443A1 FR7734602A FR7734602A FR2371443A1 FR 2371443 A1 FR2371443 A1 FR 2371443A1 FR 7734602 A FR7734602 A FR 7734602A FR 7734602 A FR7734602 A FR 7734602A FR 2371443 A1 FR2371443 A1 FR 2371443A1
- Authority
- FR
- France
- Prior art keywords
- preparation
- chemical compounds
- methods
- compounds useful
- uterine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- -1 2-hydroxyethylidene Chemical group 0.000 abstract 1
- XRDHAXIOHKTIGF-UKHUEATNSA-N 9-[(2r,3s,6e)-3-hydroxy-6-(2-hydroxyethylidene)-2-methyloxepan-2-yl]-2,6-dimethylnon-2-en-5-one Chemical compound CC(C)=CCC(=O)C(C)CCC[C@@]1(C)OC\C(=C\CO)CC[C@@H]1O XRDHAXIOHKTIGF-UKHUEATNSA-N 0.000 abstract 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 abstract 1
- XRDHAXIOHKTIGF-UHFFFAOYSA-N Zoapatanol Natural products CC(C)=CCC(=O)C(C)CCCC1(C)OCC(=CCO)CCC1O XRDHAXIOHKTIGF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 125000003551 oxepanyl group Chemical group 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/04—Seven-membered rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne des composés chimiques d'extraits de la plante zoapatle. Ces composés ont un noyau oxépane substitué, et ont pour matières premières du 2S,3R-6-(2-hydroxyéthylidène)-2-méthyl-2-(4,8-diméthyl-5-oxo-7-nonényl)-oxépan-3-ol, et du 2S,3R-6E-(2-hydroxyéthylidène)-2-méthyl-2-(5-oxo-4,7,8-triméthyl-6E-nonényl)-oxépan-3-ol. L'invention s'applique notamment à la préparation de substances ayant des propriétés d'évacuation utérine ou pouvant induire des contractions utérines.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/742,940 US4102895A (en) | 1976-11-18 | 1976-11-18 | Oxepanes |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2371443A1 true FR2371443A1 (fr) | 1978-06-16 |
FR2371443B1 FR2371443B1 (fr) | 1984-02-24 |
Family
ID=24986860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7734602A Granted FR2371443A1 (fr) | 1976-11-18 | 1977-11-17 | Composes chimiques utiles en particulier comme agents d'evacuation uterine, et procedes de preparation |
Country Status (15)
Country | Link |
---|---|
US (1) | US4102895A (fr) |
JP (1) | JPS5365890A (fr) |
AT (1) | AT363478B (fr) |
AU (1) | AU516476B2 (fr) |
CA (1) | CA1113478A (fr) |
CH (3) | CH627469A5 (fr) |
DE (1) | DE2751396A1 (fr) |
FR (1) | FR2371443A1 (fr) |
GB (1) | GB1594100A (fr) |
GR (1) | GR63241B (fr) |
IE (1) | IE45915B1 (fr) |
IL (1) | IL53420A (fr) |
NZ (1) | NZ185641A (fr) |
PH (1) | PH13596A (fr) |
ZA (1) | ZA776879B (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2429789A1 (fr) * | 1978-06-29 | 1980-01-25 | Ortho Pharma Corp | Synthese totale de la substance utero-evacuante d,l-zoapatanol, derivee de la plante zoapatle |
EP0116375A1 (fr) * | 1980-05-02 | 1984-08-22 | Ortho Pharmaceutical Corporation | Acide (1RS, 4SR, 5RS)-4-(5-hydroxy-4,8-diméthyl-8-nonen-1-yl)-4-méthyl-3,8-dioxabicyclo(3.2.1.)octane-1-acétique et procédé pour sa préparation |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4182717A (en) * | 1978-06-29 | 1980-01-08 | Ortho Pharmaceutical Corp. | Total synthesis of the utero-evacuant substance d,l-zoapatanol |
US4256644A (en) * | 1978-12-18 | 1981-03-17 | Ortho Pharmaceutical Corporation | Chemical intermediates in the preparation of oxepane compounds |
US4215048A (en) * | 1979-05-18 | 1980-07-29 | Ortho Pharmaceutical Corporation | Total synthesis of (1RS, 4SR, 5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
US4237054A (en) * | 1979-05-18 | 1980-12-02 | Ortho Pharmaceutical Corporation | Total synthesis of (1RS,4SR,5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo[3.2.1] octane-1-acetic acid |
US4237055A (en) * | 1979-06-18 | 1980-12-02 | Ortho Pharmaceutical Corporation | Synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
US4322353A (en) * | 1980-04-18 | 1982-03-30 | Ortho Pharmaceutical Corporation | Synthesis of dioxabicyclo(3.2.1)octanes and oxepanes |
US4329288A (en) * | 1980-05-02 | 1982-05-11 | Ortho Pharmaceutical Corporation | (1RS,4SR,5RS)-4-(5-Hydroxy-4,8-dimethyl-8-nonenyl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
KR850000218B1 (ko) * | 1980-07-31 | 1985-03-06 | 오오소오 화아마슈이티갈 코오포레이숀 | 디옥사비시클로[3.2.1]옥탄 유도체의 합성방법 |
US4277401A (en) * | 1980-08-25 | 1981-07-07 | Ortho Pharmaceutical Corporation | Total synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl)-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
US4307019A (en) * | 1980-08-25 | 1981-12-22 | Ortho Pharmaceutical Corporation | Total synthesis of 1RS,4SR,5RS,-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
US4360467A (en) * | 1981-02-23 | 1982-11-23 | Ortho Pharmaceutical Corporation | Process for preparing 8-oxabicyclo[3.2.1]-octane-1-acetic acids |
US4322357A (en) * | 1981-02-23 | 1982-03-30 | Ortho Pharmaceutical Corporation | Novel cycloheptanes |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2515670C2 (de) * | 1975-04-10 | 1985-07-25 | Ortho Pharmaceutical Corp., Raritan, N.J. | Verfahren zum Isolieren von Substanzen mit uteroevakuierender Wirkung aus der Zoapatl-Pflanze und diese Substanzen enthaltende Arzneimittel |
-
1976
- 1976-11-18 US US05/742,940 patent/US4102895A/en not_active Expired - Lifetime
-
1977
- 1977-11-08 NZ NZ185641A patent/NZ185641A/en unknown
- 1977-11-10 GB GB46828/77A patent/GB1594100A/en not_active Expired
- 1977-11-16 CH CH1401977A patent/CH627469A5/fr not_active IP Right Cessation
- 1977-11-16 JP JP13678877A patent/JPS5365890A/ja active Granted
- 1977-11-17 IE IE2339/77A patent/IE45915B1/en unknown
- 1977-11-17 DE DE19772751396 patent/DE2751396A1/de not_active Ceased
- 1977-11-17 GR GR54828A patent/GR63241B/el unknown
- 1977-11-17 ZA ZA00776879A patent/ZA776879B/xx unknown
- 1977-11-17 AT AT0824077A patent/AT363478B/de not_active IP Right Cessation
- 1977-11-17 FR FR7734602A patent/FR2371443A1/fr active Granted
- 1977-11-17 AU AU30729/77A patent/AU516476B2/en not_active Expired
- 1977-11-17 CA CA291,123A patent/CA1113478A/fr not_active Expired
- 1977-11-17 IL IL53420A patent/IL53420A/xx unknown
- 1977-11-21 PH PH20456A patent/PH13596A/en unknown
-
1981
- 1981-02-04 CH CH75081A patent/CH629792A5/fr not_active IP Right Cessation
- 1981-02-04 CH CH75181A patent/CH629793A5/fr not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2429789A1 (fr) * | 1978-06-29 | 1980-01-25 | Ortho Pharma Corp | Synthese totale de la substance utero-evacuante d,l-zoapatanol, derivee de la plante zoapatle |
EP0116375A1 (fr) * | 1980-05-02 | 1984-08-22 | Ortho Pharmaceutical Corporation | Acide (1RS, 4SR, 5RS)-4-(5-hydroxy-4,8-diméthyl-8-nonen-1-yl)-4-méthyl-3,8-dioxabicyclo(3.2.1.)octane-1-acétique et procédé pour sa préparation |
Also Published As
Publication number | Publication date |
---|---|
US4102895A (en) | 1978-07-25 |
PH13596A (en) | 1980-08-05 |
DE2751396A1 (de) | 1978-05-24 |
NZ185641A (en) | 1984-08-24 |
ATA824077A (de) | 1981-01-15 |
IL53420A0 (en) | 1978-01-31 |
FR2371443B1 (fr) | 1984-02-24 |
CH627469A5 (fr) | 1982-01-15 |
JPS5365890A (en) | 1978-06-12 |
ZA776879B (en) | 1979-06-27 |
AU516476B2 (en) | 1981-06-04 |
CH629792A5 (fr) | 1982-05-14 |
JPS625154B2 (fr) | 1987-02-03 |
AU3072977A (en) | 1979-05-24 |
AT363478B (de) | 1981-08-10 |
CH629793A5 (fr) | 1982-05-14 |
IL53420A (en) | 1983-05-15 |
GB1594100A (en) | 1981-07-30 |
CA1113478A (fr) | 1981-12-01 |
GR63241B (en) | 1979-10-12 |
IE45915L (en) | 1978-05-18 |
IE45915B1 (en) | 1982-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |