FR2368452A1 - Derives radio-iodes de carbamates hydroxyles et leur application a l'analyse de fluides biologiques - Google Patents
Derives radio-iodes de carbamates hydroxyles et leur application a l'analyse de fluides biologiquesInfo
- Publication number
- FR2368452A1 FR2368452A1 FR7803365A FR7803365A FR2368452A1 FR 2368452 A1 FR2368452 A1 FR 2368452A1 FR 7803365 A FR7803365 A FR 7803365A FR 7803365 A FR7803365 A FR 7803365A FR 2368452 A1 FR2368452 A1 FR 2368452A1
- Authority
- FR
- France
- Prior art keywords
- analysis
- application
- biological fluids
- derivatives
- carbamates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004458 analytical method Methods 0.000 title abstract 3
- 239000013060 biological fluid Substances 0.000 title abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 title 1
- XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical class [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000004159 blood analysis Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne des dérivés marqués à l'iode radio-actif qui servent à l'analyse de divers composés des fluides biologiques. Ces dérivés sont obtenus par réaction d'un composé tel qu'un stéroïde ou une hormone, avec un isocyanate hydroxylé protégé, élimination du groupe protecteur et radio-iodation. Ces derivés permettent l'analyse des réactions antigène-anticorps dans le sang, d'une manière quantitative par comptage de désintégrations. Application à l'analyse du sang.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/687,149 US4115539A (en) | 1976-05-17 | 1976-05-17 | Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2368452A1 true FR2368452A1 (fr) | 1978-05-19 |
FR2368452B1 FR2368452B1 (fr) | 1985-09-06 |
Family
ID=24759277
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7714947A Granted FR2369284A1 (fr) | 1976-05-17 | 1977-05-16 | Produits de reaction d'isocyanates silyles avec des composes interessants du point de vue chimiqu |
FR7803364A Granted FR2368453A1 (fr) | 1976-05-17 | 1978-02-07 | Carbamates hydroxyles provenant de la reaction d'isocyanates avec des composes interessants du point de vue chimique |
FR7803365A Expired FR2368452B1 (fr) | 1976-05-17 | 1978-02-07 | Derives radio-iodes de carbamates hydroxyles et leur application a l'analyse de fluides biologiques |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7714947A Granted FR2369284A1 (fr) | 1976-05-17 | 1977-05-16 | Produits de reaction d'isocyanates silyles avec des composes interessants du point de vue chimiqu |
FR7803364A Granted FR2368453A1 (fr) | 1976-05-17 | 1978-02-07 | Carbamates hydroxyles provenant de la reaction d'isocyanates avec des composes interessants du point de vue chimique |
Country Status (13)
Country | Link |
---|---|
US (1) | US4115539A (fr) |
JP (2) | JPS5315359A (fr) |
AU (1) | AU519191B2 (fr) |
BE (1) | BE854692A (fr) |
BR (1) | BR7703146A (fr) |
CA (1) | CA1093486A (fr) |
DE (1) | DE2722038C2 (fr) |
DK (1) | DK213177A (fr) |
FR (3) | FR2369284A1 (fr) |
GB (2) | GB1586185A (fr) |
IL (1) | IL52095A0 (fr) |
NL (1) | NL7705411A (fr) |
SE (2) | SE447025B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2433509A1 (fr) * | 1978-08-17 | 1980-03-14 | Sheludyakov Viktor | Procede de preparation d'isocyanates |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4256833A (en) * | 1979-01-08 | 1981-03-17 | Majid Ali | Enzyme immunoassay for allergic disorders |
US4358435A (en) * | 1980-06-09 | 1982-11-09 | The Research Foundation Of State University Of New York | Ligand compositions and processes for their manufacture and their use in radioimmunoassay |
US4670406A (en) * | 1984-01-06 | 1987-06-02 | Becton Dickinson And Company | Tracers for use in assays |
US4595656A (en) * | 1984-01-06 | 1986-06-17 | Becton Dickinson & Company | Coupling agents and products produced therefrom |
CA1290701C (fr) * | 1984-07-05 | 1991-10-15 | Jerald C. Nelson | Cellule pour dialyse |
US4736046A (en) * | 1985-12-23 | 1988-04-05 | The Dow Chemical Company | β-isocyanato organosilanes |
GB9625895D0 (en) * | 1996-12-13 | 1997-01-29 | Riley Patrick A | Novel compound useful as therapeutic agents and assay reagents |
EP1303481A1 (fr) * | 2000-07-26 | 2003-04-23 | Patrick Anthony Riley | Derives de phenylethylamine et leur utilisation dans le traitement de melanome |
EP3296313B1 (fr) * | 2010-01-15 | 2020-12-16 | Suzhou Neupharma Co., Ltd | Certaines entités chimiques, compositions et procédés |
CN102656179B (zh) | 2010-08-28 | 2015-07-29 | 苏州润新生物科技有限公司 | 蟾蜍灵衍生物、其药物组合物及用途 |
CN103619865B (zh) * | 2011-02-02 | 2016-10-12 | 苏州润新生物科技有限公司 | 某些化学个体、组合物及方法 |
CN109354598A (zh) | 2012-04-29 | 2019-02-19 | 润新生物公司 | 化学个体、药物组合物及癌症治疗方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2285613A1 (fr) * | 1974-09-11 | 1976-04-16 | Abbott Lab | Dosage radio-immunologique competitif de la digoxine dans le serum |
US3963697A (en) * | 1974-08-29 | 1976-06-15 | Curtis Nuclear Corporation | Labelled cardiotonic glycosides for use in radioimmunoassay |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3953431A (en) * | 1971-05-24 | 1976-04-27 | Becton, Dickinson & Company | Derivatives of digoxigenin |
US3996344A (en) * | 1972-05-15 | 1976-12-07 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies and use |
US3843696A (en) * | 1972-09-05 | 1974-10-22 | Syva Co | Methadone analog compounds |
US3878187A (en) * | 1972-09-11 | 1975-04-15 | Syva Co | Polypeptide derivatives of amphetamine and analogs for immunoassays |
US3867366A (en) * | 1972-11-06 | 1975-02-18 | Synvar Associates A K A Syva C | Opiate imidates and protein conjugates thereof |
US3888866A (en) * | 1973-06-01 | 1975-06-10 | Syva Co | Nitrogen derivatives of benzoyl ecgonine |
SE396478B (sv) * | 1974-04-03 | 1977-09-19 | Pharmacia Ab | Radioaktivt merkt antigen, hapten eller antikropp for anvendning vid radioimmunologiska bestemningsmetoder |
-
1976
- 1976-05-17 US US05/687,149 patent/US4115539A/en not_active Expired - Lifetime
-
1977
- 1977-05-04 SE SE7705191A patent/SE447025B/xx not_active IP Right Cessation
- 1977-05-16 BE BE177621A patent/BE854692A/fr unknown
- 1977-05-16 BR BR7703146A patent/BR7703146A/pt unknown
- 1977-05-16 DK DK213177A patent/DK213177A/da unknown
- 1977-05-16 IL IL52095A patent/IL52095A0/xx unknown
- 1977-05-16 GB GB20472/77A patent/GB1586185A/en not_active Expired
- 1977-05-16 JP JP5553677A patent/JPS5315359A/ja active Pending
- 1977-05-16 GB GB25202/79A patent/GB1586186A/en not_active Expired
- 1977-05-16 CA CA278,492A patent/CA1093486A/fr not_active Expired
- 1977-05-16 NL NL7705411A patent/NL7705411A/xx not_active Application Discontinuation
- 1977-05-16 DE DE2722038A patent/DE2722038C2/de not_active Expired
- 1977-05-16 FR FR7714947A patent/FR2369284A1/fr active Granted
- 1977-05-17 AU AU25187/77A patent/AU519191B2/en not_active Ceased
-
1978
- 1978-02-07 FR FR7803364A patent/FR2368453A1/fr active Granted
- 1978-02-07 FR FR7803365A patent/FR2368452B1/fr not_active Expired
-
1982
- 1982-06-30 JP JP57111828A patent/JPS5823699A/ja active Granted
- 1982-10-08 SE SE8205750A patent/SE446738B/sv not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3963697A (en) * | 1974-08-29 | 1976-06-15 | Curtis Nuclear Corporation | Labelled cardiotonic glycosides for use in radioimmunoassay |
FR2285613A1 (fr) * | 1974-09-11 | 1976-04-16 | Abbott Lab | Dosage radio-immunologique competitif de la digoxine dans le serum |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2433509A1 (fr) * | 1978-08-17 | 1980-03-14 | Sheludyakov Viktor | Procede de preparation d'isocyanates |
Also Published As
Publication number | Publication date |
---|---|
US4115539A (en) | 1978-09-19 |
SE446738B (sv) | 1986-10-06 |
FR2368453B1 (fr) | 1981-10-02 |
IL52095A0 (en) | 1977-07-31 |
SE8205750L (sv) | 1982-10-08 |
AU2518777A (en) | 1978-11-23 |
DK213177A (da) | 1977-11-18 |
NL7705411A (nl) | 1977-11-21 |
GB1586185A (en) | 1981-03-18 |
JPS5823699A (ja) | 1983-02-12 |
BR7703146A (pt) | 1978-04-04 |
FR2368453A1 (fr) | 1978-05-19 |
AU519191B2 (en) | 1981-11-19 |
BE854692A (fr) | 1977-11-16 |
SE447025B (sv) | 1986-10-20 |
DE2722038A1 (de) | 1977-12-15 |
FR2369284B1 (fr) | 1981-10-02 |
FR2369284A1 (fr) | 1978-05-26 |
SE7705191L (sv) | 1977-11-18 |
CA1093486A (fr) | 1981-01-13 |
FR2368452B1 (fr) | 1985-09-06 |
GB1586186A (en) | 1981-03-18 |
SE8205750D0 (sv) | 1982-10-08 |
JPS6332356B2 (fr) | 1988-06-29 |
DE2722038C2 (de) | 1983-05-19 |
JPS5315359A (en) | 1978-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |