FR2361349A1 - Enkephalines substituees en position i, leurs procedes de preparation et leur utilisation comme analgesiques et antidiarrheiques - Google Patents
Enkephalines substituees en position i, leurs procedes de preparation et leur utilisation comme analgesiques et antidiarrheiquesInfo
- Publication number
- FR2361349A1 FR2361349A1 FR7724537A FR7724537A FR2361349A1 FR 2361349 A1 FR2361349 A1 FR 2361349A1 FR 7724537 A FR7724537 A FR 7724537A FR 7724537 A FR7724537 A FR 7724537A FR 2361349 A1 FR2361349 A1 FR 2361349A1
- Authority
- FR
- France
- Prior art keywords
- analgesics
- substituted
- antidiarrheics
- enkephalins
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C07K14/702—Enkephalins with at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Les composés de l'invention sont des analogues de la méthionine**5-enképhaline ou de la leucine**5-enképhaline dont le radical en position 1 est substitué par divers autres restes d'amino-acides. Les composés de l'invention, qui sont des agonistes actifs sur les sites récepteurs des opiacés, constituent des médicaments utiles notamment comme analgésiques, antagonistes des narcotiques et agents antidiarrhéiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71262676A | 1976-08-09 | 1976-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2361349A1 true FR2361349A1 (fr) | 1978-03-10 |
Family
ID=24862912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7724537A Withdrawn FR2361349A1 (fr) | 1976-08-09 | 1977-08-09 | Enkephalines substituees en position i, leurs procedes de preparation et leur utilisation comme analgesiques et antidiarrheiques |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS5321140A (fr) |
AU (1) | AU2768977A (fr) |
DE (1) | DE2735674A1 (fr) |
FR (1) | FR2361349A1 (fr) |
GB (1) | GB1532148A (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2655149A1 (de) * | 1975-12-17 | 1977-06-23 | Sandoz Ag | Polypeptide und deren derivate |
FR2338925A1 (fr) * | 1976-01-26 | 1977-08-19 | Wellcome Found | Nouveaux peptides et medicament contenant ces substances |
FR2339590A1 (fr) * | 1976-02-02 | 1977-08-26 | Sandoz Sa | Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments |
-
1977
- 1977-08-08 JP JP9491877A patent/JPS5321140A/ja active Pending
- 1977-08-08 GB GB33220/77A patent/GB1532148A/en not_active Expired
- 1977-08-08 DE DE19772735674 patent/DE2735674A1/de active Pending
- 1977-08-08 AU AU27689/77A patent/AU2768977A/en active Pending
- 1977-08-09 FR FR7724537A patent/FR2361349A1/fr not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2655149A1 (de) * | 1975-12-17 | 1977-06-23 | Sandoz Ag | Polypeptide und deren derivate |
FR2338925A1 (fr) * | 1976-01-26 | 1977-08-19 | Wellcome Found | Nouveaux peptides et medicament contenant ces substances |
FR2339590A1 (fr) * | 1976-02-02 | 1977-08-26 | Sandoz Sa | Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments |
Non-Patent Citations (2)
Title |
---|
EXBK/76 * |
NV2030/76 * |
Also Published As
Publication number | Publication date |
---|---|
AU2768977A (en) | 1979-02-15 |
DE2735674A1 (de) | 1978-02-16 |
JPS5321140A (en) | 1978-02-27 |
GB1532148A (en) | 1978-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |