FR2361349A1 - Enkephalines substituees en position i, leurs procedes de preparation et leur utilisation comme analgesiques et antidiarrheiques - Google Patents

Enkephalines substituees en position i, leurs procedes de preparation et leur utilisation comme analgesiques et antidiarrheiques

Info

Publication number
FR2361349A1
FR2361349A1 FR7724537A FR7724537A FR2361349A1 FR 2361349 A1 FR2361349 A1 FR 2361349A1 FR 7724537 A FR7724537 A FR 7724537A FR 7724537 A FR7724537 A FR 7724537A FR 2361349 A1 FR2361349 A1 FR 2361349A1
Authority
FR
France
Prior art keywords
analgesics
substituted
antidiarrheics
enkephalins
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7724537A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of FR2361349A1 publication Critical patent/FR2361349A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Les composés de l'invention sont des analogues de la méthionine**5-enképhaline ou de la leucine**5-enképhaline dont le radical en position 1 est substitué par divers autres restes d'amino-acides. Les composés de l'invention, qui sont des agonistes actifs sur les sites récepteurs des opiacés, constituent des médicaments utiles notamment comme analgésiques, antagonistes des narcotiques et agents antidiarrhéiques.
FR7724537A 1976-08-09 1977-08-09 Enkephalines substituees en position i, leurs procedes de preparation et leur utilisation comme analgesiques et antidiarrheiques Withdrawn FR2361349A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71262676A 1976-08-09 1976-08-09

Publications (1)

Publication Number Publication Date
FR2361349A1 true FR2361349A1 (fr) 1978-03-10

Family

ID=24862912

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7724537A Withdrawn FR2361349A1 (fr) 1976-08-09 1977-08-09 Enkephalines substituees en position i, leurs procedes de preparation et leur utilisation comme analgesiques et antidiarrheiques

Country Status (5)

Country Link
JP (1) JPS5321140A (fr)
AU (1) AU2768977A (fr)
DE (1) DE2735674A1 (fr)
FR (1) FR2361349A1 (fr)
GB (1) GB1532148A (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655149A1 (de) * 1975-12-17 1977-06-23 Sandoz Ag Polypeptide und deren derivate
FR2338925A1 (fr) * 1976-01-26 1977-08-19 Wellcome Found Nouveaux peptides et medicament contenant ces substances
FR2339590A1 (fr) * 1976-02-02 1977-08-26 Sandoz Sa Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655149A1 (de) * 1975-12-17 1977-06-23 Sandoz Ag Polypeptide und deren derivate
FR2338925A1 (fr) * 1976-01-26 1977-08-19 Wellcome Found Nouveaux peptides et medicament contenant ces substances
FR2339590A1 (fr) * 1976-02-02 1977-08-26 Sandoz Sa Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *
NV2030/76 *

Also Published As

Publication number Publication date
GB1532148A (en) 1978-11-15
AU2768977A (en) 1979-02-15
DE2735674A1 (de) 1978-02-16
JPS5321140A (en) 1978-02-27

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Legal Events

Date Code Title Description
ST Notification of lapse