FR2354999A1 - Nouvel ester de p-hydroxyphenyluree de l'ibuprofene et son procede de preparation - Google Patents
Nouvel ester de p-hydroxyphenyluree de l'ibuprofene et son procede de preparationInfo
- Publication number
- FR2354999A1 FR2354999A1 FR7718570A FR7718570A FR2354999A1 FR 2354999 A1 FR2354999 A1 FR 2354999A1 FR 7718570 A FR7718570 A FR 7718570A FR 7718570 A FR7718570 A FR 7718570A FR 2354999 A1 FR2354999 A1 FR 2354999A1
- Authority
- FR
- France
- Prior art keywords
- ester
- hydroxyphenyluree
- ibuprofene
- new
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title 1
- MHVJUTLRTHDAOG-UHFFFAOYSA-N p-hydroxyphenylurea Natural products NC(=O)NC1=CC=C(O)C=C1 MHVJUTLRTHDAOG-UHFFFAOYSA-N 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- 229960001680 ibuprofen Drugs 0.000 abstract 2
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 p-hydroxyphenylurea ester Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/696,947 US4049700A (en) | 1976-06-17 | 1976-06-17 | Ibuprofen p-hydroxyphenylurea ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2354999A1 true FR2354999A1 (fr) | 1978-01-13 |
| FR2354999B1 FR2354999B1 (enExample) | 1980-03-21 |
Family
ID=24799157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7718570A Granted FR2354999A1 (fr) | 1976-06-17 | 1977-06-16 | Nouvel ester de p-hydroxyphenyluree de l'ibuprofene et son procede de preparation |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4049700A (enExample) |
| JP (1) | JPS6021137B2 (enExample) |
| BE (1) | BE855824A (enExample) |
| CA (1) | CA1088094A (enExample) |
| DE (1) | DE2724183C2 (enExample) |
| FR (1) | FR2354999A1 (enExample) |
| GB (1) | GB1538416A (enExample) |
| NL (1) | NL7706619A (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1113331B (it) * | 1979-03-27 | 1986-01-20 | Neopharmed Spa | Esteri della salicilammide con attivita' terapeutica,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| JPS63155237U (enExample) * | 1987-03-31 | 1988-10-12 | ||
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5310960A (en) * | 1993-07-02 | 1994-05-10 | Affinity Biotech, Inc. | Low temperature process for preparing neomorphic ibuprofen |
| US5466865A (en) * | 1993-07-02 | 1995-11-14 | Ibah, Inc. | Neomorphic ibuprofen and methods of using same |
| US5310961A (en) * | 1993-07-02 | 1994-05-10 | Affinity Biotech, Inc. | Neomorphic ibuprofen |
| US20070053984A1 (en) * | 2005-03-03 | 2007-03-08 | Monique Spann-Wade | Topical gels compositions |
| US20080317684A1 (en) * | 2006-09-06 | 2008-12-25 | Isw Group, Inc. | Topical Compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2270859A1 (enExample) * | 1974-05-15 | 1975-12-12 | Acraf |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931285A (en) * | 1974-01-08 | 1976-01-06 | The Upjohn Company | Substituted tolyl esters of PGE1 |
-
1976
- 1976-06-17 US US05/696,947 patent/US4049700A/en not_active Expired - Lifetime
-
1977
- 1977-05-19 CA CA278,818A patent/CA1088094A/en not_active Expired
- 1977-05-27 DE DE2724183A patent/DE2724183C2/de not_active Expired
- 1977-06-01 GB GB23162/77A patent/GB1538416A/en not_active Expired
- 1977-06-16 NL NL7706619A patent/NL7706619A/xx not_active Application Discontinuation
- 1977-06-16 FR FR7718570A patent/FR2354999A1/fr active Granted
- 1977-06-17 JP JP52071982A patent/JPS6021137B2/ja not_active Expired
- 1977-06-17 BE BE178549A patent/BE855824A/xx not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2270859A1 (enExample) * | 1974-05-15 | 1975-12-12 | Acraf |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1538416A (en) | 1979-01-17 |
| US4049700A (en) | 1977-09-20 |
| NL7706619A (nl) | 1977-12-20 |
| CA1088094A (en) | 1980-10-21 |
| DE2724183C2 (de) | 1986-03-13 |
| FR2354999B1 (enExample) | 1980-03-21 |
| DE2724183A1 (de) | 1978-01-05 |
| JPS52153939A (en) | 1977-12-21 |
| JPS6021137B2 (ja) | 1985-05-25 |
| BE855824A (fr) | 1977-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |