FR2354340A1 - Procede pour la recuperation de l'antithrombine iii - Google Patents
Procede pour la recuperation de l'antithrombine iiiInfo
- Publication number
- FR2354340A1 FR2354340A1 FR7717655A FR7717655A FR2354340A1 FR 2354340 A1 FR2354340 A1 FR 2354340A1 FR 7717655 A FR7717655 A FR 7717655A FR 7717655 A FR7717655 A FR 7717655A FR 2354340 A1 FR2354340 A1 FR 2354340A1
- Authority
- FR
- France
- Prior art keywords
- antithrombin iii
- albumin
- factor viii
- recovering
- gamma globulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y10S530/831—Cohn fractions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'antithrombine III de grande pureté est obtenue à partir du plasma de sang humain. D'abord le fibrinogène et le facteur VIII sont séparés par précipitation. La prothrombine est récupérée sous la forme d'un adsorbat sur du phosphate tricalcique finement divisé. L'albumine et la gamma globuline se retrouvent dans un surnageant aqueux. L'antithrombine est recueillie dans une phase précipitée. Le procédé permet d'obtenir les fibrinogènes, facteur VIII, complexe de prothrombine, albumine, gamma globuline et impuretés protéiniques sous des formes susceptibles de donner lieu à des préparation utiles.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/694,167 US4087415A (en) | 1976-06-09 | 1976-06-09 | Antithrombin III |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2354340A1 true FR2354340A1 (fr) | 1978-01-06 |
FR2354340B1 FR2354340B1 (fr) | 1982-09-10 |
Family
ID=24787683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7717655A Granted FR2354340A1 (fr) | 1976-06-09 | 1977-06-09 | Procede pour la recuperation de l'antithrombine iii |
Country Status (4)
Country | Link |
---|---|
US (1) | US4087415A (fr) |
JP (1) | JPS52151710A (fr) |
DE (1) | DE2725711A1 (fr) |
FR (1) | FR2354340A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1980002426A1 (fr) * | 1979-05-04 | 1980-11-13 | Merieux Inst | Concentres de complexe prothrombinique, preparation et application |
FR2460138A1 (fr) * | 1978-01-07 | 1981-01-23 | Green Cross Corp | Preparation antithrombinique et son procede de fabrication |
EP0090505A2 (fr) * | 1982-03-03 | 1983-10-05 | Genentech, Inc. | Antithrombine III humaine, séquences d'ADN pour celli-ci, vecteurs de clonage et d'expression contenant ces sequences et cultures de cellules transformées par ceux-ci, procédé pour exprimer l'antithrombine III humaine et compositions pharmaceutiques la contenant |
US4517294A (en) * | 1982-03-03 | 1985-05-14 | Genentech, Inc. | Human antithrombin III |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1603244A (en) * | 1977-05-20 | 1981-11-18 | Max Planck Gesellschaft | Medicaments for the suppression of pathological processes |
US4170639A (en) * | 1978-07-10 | 1979-10-09 | Warner-Lambert Company | Antihemophilic factor concentrate and its production |
DE2902158A1 (de) * | 1979-01-20 | 1980-07-31 | Biotest Serum Institut Gmbh | Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen |
SE448945B (sv) * | 1979-12-20 | 1987-03-30 | Blombaeck E G B | Forfarande for rening och /eller koncentrering av faktor viii-komplexet |
JPS5699422A (en) * | 1980-01-10 | 1981-08-10 | Toyo Soda Mfg Co Ltd | Separation of plasma albumin |
US4287180A (en) * | 1980-01-28 | 1981-09-01 | Baxter Travenol Laboratories, Inc. | Method for treating blood clotting factor inhibitors |
US4386025A (en) * | 1980-09-30 | 1983-05-31 | Cutter Laboratories, Inc. | Method of preparing antithrombin |
US4446314A (en) * | 1980-09-30 | 1984-05-01 | Cutter Laboratories, Inc. | Fractionation of heparin |
DE3038163A1 (de) * | 1980-10-09 | 1982-05-06 | Boehringer Mannheim Gmbh, 6800 Mannheim | Thrombininhibitor, seine herstellung und verwendung |
US4632981A (en) * | 1982-07-30 | 1986-12-30 | Genentech, Inc. | Human antithrombin III |
AT379310B (de) * | 1983-05-20 | 1985-12-27 | Immuno Ag | Verfahren zur herstellung eines antithrombin iii-heparin- bzw. antithrombin iii-heparinoidkonzentrates |
AU578554B2 (en) * | 1986-01-24 | 1988-10-27 | Japanese Red Cross Society | Centrifugal method of separating blood components |
AU768076B2 (en) | 1998-10-08 | 2003-12-04 | Children's Hospital | Compositions and methods for inhibiting angiogenesis |
SE0203770D0 (sv) * | 2002-12-19 | 2002-12-19 | Biovitrum Ab | Method of separation |
PT2503995T (pt) * | 2009-11-24 | 2017-11-23 | Grifols Therapeutics Inc | Métodos de liofilização, composições e kits |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2154483A1 (fr) * | 1971-09-08 | 1973-05-11 | Kabi Ab |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3631018A (en) * | 1970-05-01 | 1971-12-28 | Baxter Laboratories Inc | Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate |
US3682881A (en) * | 1970-10-02 | 1972-08-08 | Baxter Laboratories Inc | Fractionation of plasma using glycine and polyethylene glycol |
US3839314A (en) * | 1971-06-29 | 1974-10-01 | Baxter Laboratories Inc | Clarification of blood serum and plasma using block copolymers of ethylene oxide and polyoxypropylene |
US3770631A (en) * | 1971-06-29 | 1973-11-06 | Baxter Laboratories Inc | Clarification of blood serum and plasma |
US3880989A (en) * | 1973-01-30 | 1975-04-29 | Baxter Laboratories Inc | Production of antisera comprising fractionating plasma or serum with an ethylene oxide-polyoxypropylene block copolymer |
US3956259A (en) * | 1973-01-30 | 1976-05-11 | Baxter Laboratories, Inc. | Fractionation of blood using block copolymer of ethylene oxide and polyoxypropylene polymer to recover fraction suitable for organ perfusate |
US3850903A (en) * | 1973-06-21 | 1974-11-26 | S Mankarious | Plasma volume expander prepared from cohn iv precipitate using block copolymers of ethylene oxide and polyoxypropylene |
-
1976
- 1976-06-09 US US05/694,167 patent/US4087415A/en not_active Expired - Lifetime
-
1977
- 1977-06-06 JP JP6721977A patent/JPS52151710A/ja active Pending
- 1977-06-07 DE DE19772725711 patent/DE2725711A1/de not_active Withdrawn
- 1977-06-09 FR FR7717655A patent/FR2354340A1/fr active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2154483A1 (fr) * | 1971-09-08 | 1973-05-11 | Kabi Ab |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2460138A1 (fr) * | 1978-01-07 | 1981-01-23 | Green Cross Corp | Preparation antithrombinique et son procede de fabrication |
WO1980002426A1 (fr) * | 1979-05-04 | 1980-11-13 | Merieux Inst | Concentres de complexe prothrombinique, preparation et application |
FR2472390A1 (fr) * | 1979-05-04 | 1981-07-03 | Merieux Inst | Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus |
EP0090505A2 (fr) * | 1982-03-03 | 1983-10-05 | Genentech, Inc. | Antithrombine III humaine, séquences d'ADN pour celli-ci, vecteurs de clonage et d'expression contenant ces sequences et cultures de cellules transformées par ceux-ci, procédé pour exprimer l'antithrombine III humaine et compositions pharmaceutiques la contenant |
EP0090505A3 (en) * | 1982-03-03 | 1984-02-22 | Genentech, Inc. | Human antithrombin iii, dna sequences therefor, expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby, a process for expressing human antithrombin iii, and pharmaceutical compositions comprising it |
US4517294A (en) * | 1982-03-03 | 1985-05-14 | Genentech, Inc. | Human antithrombin III |
Also Published As
Publication number | Publication date |
---|---|
US4087415A (en) | 1978-05-02 |
FR2354340B1 (fr) | 1982-09-10 |
DE2725711A1 (de) | 1977-12-22 |
JPS52151710A (en) | 1977-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CA | Change of address | ||
TP | Transmission of property | ||
ST | Notification of lapse |