FR2346010A2 - Procede de preparation du chlorhydrate de n-nicotinoyl o-p-chloro phenoxy isobutanoyl ethanol amine, utile dans le traitement des dislipidemies et la prevention de l'atherosclerose - Google Patents
Procede de preparation du chlorhydrate de n-nicotinoyl o-p-chloro phenoxy isobutanoyl ethanol amine, utile dans le traitement des dislipidemies et la prevention de l'atheroscleroseInfo
- Publication number
- FR2346010A2 FR2346010A2 FR7609253A FR7609253A FR2346010A2 FR 2346010 A2 FR2346010 A2 FR 2346010A2 FR 7609253 A FR7609253 A FR 7609253A FR 7609253 A FR7609253 A FR 7609253A FR 2346010 A2 FR2346010 A2 FR 2346010A2
- Authority
- FR
- France
- Prior art keywords
- treatment
- isobutanoyl
- nicotinoyl
- useful
- dislipidemias
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HZAXFHJVJLSVMW-UHFFFAOYSA-N monoethanolamine hydrochloride Natural products NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 title abstract 5
- UFUYXOVKNKIDFN-UHFFFAOYSA-N 2-hydroxy-4-methyl-2-phenoxypentan-3-one Chemical compound O(C1=CC=CC=C1)C(C)(O)C(C(C)C)=O UFUYXOVKNKIDFN-UHFFFAOYSA-N 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 title 1
- 229940073579 ethanolamine hydrochloride Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- XBLVHTDFJBKJLG-UHFFFAOYSA-N Ethyl nicotinate Chemical compound CCOC(=O)C1=CC=CN=C1 XBLVHTDFJBKJLG-UHFFFAOYSA-N 0.000 abstract 4
- OODRWLGKUBMFLZ-UHFFFAOYSA-N 2-(4-chlorophenoxy)-2-methylpropanoyl chloride Chemical compound ClC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 OODRWLGKUBMFLZ-UHFFFAOYSA-N 0.000 abstract 2
- 229940031098 ethanolamine Drugs 0.000 abstract 2
- 229940064982 ethylnicotinate Drugs 0.000 abstract 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 abstract 2
- KMQANHOODDGGJW-UHFFFAOYSA-N Cl.C(C(C)C)(=O)C(O)CN Chemical compound Cl.C(C(C)C)(=O)C(O)CN KMQANHOODDGGJW-UHFFFAOYSA-N 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7609253A FR2346010A2 (fr) | 1976-03-29 | 1976-03-29 | Procede de preparation du chlorhydrate de n-nicotinoyl o-p-chloro phenoxy isobutanoyl ethanol amine, utile dans le traitement des dislipidemies et la prevention de l'atherosclerose |
ES457244A ES457244A1 (es) | 1976-03-29 | 1977-03-26 | Un procedimiento de preparacion del clorhidrato de n-nicoti-noil-3-p-cloro-fenoxi-isobutanoil-etanol-amina. |
CA274,862A CA1095051A (fr) | 1976-03-29 | 1977-03-28 | Preparation du chlorhydrate de n-nicotinoyl o-p- chloro phenoxy isobutanoly ethanol amine |
ZA00771892A ZA771892B (en) | 1976-03-29 | 1977-03-29 | Process for the preparation of n-nicotinoyl-o-p-chlorophenoxyisobutanoyl-ethanol-amine hydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7609253A FR2346010A2 (fr) | 1976-03-29 | 1976-03-29 | Procede de preparation du chlorhydrate de n-nicotinoyl o-p-chloro phenoxy isobutanoyl ethanol amine, utile dans le traitement des dislipidemies et la prevention de l'atherosclerose |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2346010A2 true FR2346010A2 (fr) | 1977-10-28 |
FR2346010B2 FR2346010B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-05-18 |
Family
ID=9171169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7609253A Granted FR2346010A2 (fr) | 1976-03-29 | 1976-03-29 | Procede de preparation du chlorhydrate de n-nicotinoyl o-p-chloro phenoxy isobutanoyl ethanol amine, utile dans le traitement des dislipidemies et la prevention de l'atherosclerose |
Country Status (4)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0161422A1 (en) * | 1984-03-21 | 1985-11-21 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Alkanolamine derivatives and platelet aggregation inhibitors containing the same as an active ingredient |
-
1976
- 1976-03-29 FR FR7609253A patent/FR2346010A2/fr active Granted
-
1977
- 1977-03-26 ES ES457244A patent/ES457244A1/es not_active Expired
- 1977-03-28 CA CA274,862A patent/CA1095051A/fr not_active Expired
- 1977-03-29 ZA ZA00771892A patent/ZA771892B/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0161422A1 (en) * | 1984-03-21 | 1985-11-21 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Alkanolamine derivatives and platelet aggregation inhibitors containing the same as an active ingredient |
US4619938A (en) * | 1984-03-21 | 1986-10-28 | Terumo Kabushiki Kaisha | Fatty acid derivatives of aminoalkyl nicotinic acid esters and platelet aggregation inhibitors |
Also Published As
Publication number | Publication date |
---|---|
ZA771892B (en) | 1978-03-29 |
ES457244A1 (es) | 1978-02-01 |
CA1095051A (fr) | 1981-02-03 |
FR2346010B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-05-18 |
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