FR2339618A1 - Procede de preparation de (-)11-aminovincamone, de 11-aminoeburamonine, de 11-aminovincamone racemique et derives indoliques nouveaux - Google Patents
Procede de preparation de (-)11-aminovincamone, de 11-aminoeburamonine, de 11-aminovincamone racemique et derives indoliques nouveauxInfo
- Publication number
- FR2339618A1 FR2339618A1 FR7602603A FR7602603A FR2339618A1 FR 2339618 A1 FR2339618 A1 FR 2339618A1 FR 7602603 A FR7602603 A FR 7602603A FR 7602603 A FR7602603 A FR 7602603A FR 2339618 A1 FR2339618 A1 FR 2339618A1
- Authority
- FR
- France
- Prior art keywords
- base
- nitro
- amino
- vincamones
- vincamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002490 cerebral effect Effects 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 abstract 2
- BMTAFVWTTFSTOG-UHFFFAOYSA-N Butylate Chemical compound CCSC(=O)N(CC(C)C)CC(C)C BMTAFVWTTFSTOG-UHFFFAOYSA-N 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- WYJAPUKIYAZSEM-MOPGFXCFSA-N Eburnamonine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)CC(=O)N5C2=C1 WYJAPUKIYAZSEM-MOPGFXCFSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- WYJAPUKIYAZSEM-UHFFFAOYSA-N rac-Eburnamonin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(=O)N5C2=C1 WYJAPUKIYAZSEM-UHFFFAOYSA-N 0.000 abstract 1
- 229960002922 vinburnine Drugs 0.000 abstract 1
- 229960002726 vincamine Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7602603A FR2339618A1 (fr) | 1976-01-30 | 1976-01-30 | Procede de preparation de (-)11-aminovincamone, de 11-aminoeburamonine, de 11-aminovincamone racemique et derives indoliques nouveaux |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7602603A FR2339618A1 (fr) | 1976-01-30 | 1976-01-30 | Procede de preparation de (-)11-aminovincamone, de 11-aminoeburamonine, de 11-aminovincamone racemique et derives indoliques nouveaux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2339618A1 true FR2339618A1 (fr) | 1977-08-26 |
| FR2339618B1 FR2339618B1 (enExample) | 1980-03-07 |
Family
ID=9168589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7602603A Granted FR2339618A1 (fr) | 1976-01-30 | 1976-01-30 | Procede de preparation de (-)11-aminovincamone, de 11-aminoeburamonine, de 11-aminovincamone racemique et derives indoliques nouveaux |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2339618A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356305A (en) * | 1979-08-13 | 1982-10-26 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the preparation of halovincamone derivatives |
| DE3322686A1 (de) * | 1982-06-30 | 1984-02-16 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | Neue eburnanderivate, verfahren zur herstellung derselben und diese enthaltende pharmazeutische praeparate |
| DE3409185A1 (de) * | 1984-04-12 | 1985-09-26 | Consiglio Nazionale Delle Ricerche, Rom/Roma | Verfahren zur herstellung von eburnamoninen auf elektrochemischem weg |
| US5093337A (en) * | 1987-11-19 | 1992-03-03 | Roussel Uclaf | Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320302A1 (fr) * | 1975-08-05 | 1977-03-04 | Omnium Chimique Sa | Procede de preparation de 11-aminovincamine dextrogyre, de 11-aminovincamine levogyre, de 11-aminovincamine racemique et derives indoliques nouveaux |
-
1976
- 1976-01-30 FR FR7602603A patent/FR2339618A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320302A1 (fr) * | 1975-08-05 | 1977-03-04 | Omnium Chimique Sa | Procede de preparation de 11-aminovincamine dextrogyre, de 11-aminovincamine levogyre, de 11-aminovincamine racemique et derives indoliques nouveaux |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356305A (en) * | 1979-08-13 | 1982-10-26 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the preparation of halovincamone derivatives |
| DE3322686A1 (de) * | 1982-06-30 | 1984-02-16 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | Neue eburnanderivate, verfahren zur herstellung derselben und diese enthaltende pharmazeutische praeparate |
| DE3409185A1 (de) * | 1984-04-12 | 1985-09-26 | Consiglio Nazionale Delle Ricerche, Rom/Roma | Verfahren zur herstellung von eburnamoninen auf elektrochemischem weg |
| US5093337A (en) * | 1987-11-19 | 1992-03-03 | Roussel Uclaf | Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2339618B1 (enExample) | 1980-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |