FR2305435A1 - Cephalosporin intermediate mercapto-substd azole derivs - prepd eg by cyclising N-acyl-dithiocarbazoic acids or their salts (BE270976) - Google Patents

Cephalosporin intermediate mercapto-substd azole derivs - prepd eg by cyclising N-acyl-dithiocarbazoic acids or their salts (BE270976)

Info

Publication number
FR2305435A1
FR2305435A1 FR7608976A FR7608976A FR2305435A1 FR 2305435 A1 FR2305435 A1 FR 2305435A1 FR 7608976 A FR7608976 A FR 7608976A FR 7608976 A FR7608976 A FR 7608976A FR 2305435 A1 FR2305435 A1 FR 2305435A1
Authority
FR
France
Prior art keywords
derivs
substd
azole
mercapto
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7608976A
Other languages
French (fr)
Other versions
FR2305435B3 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7512813A external-priority patent/GB1542397A/en
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of FR2305435A1 publication Critical patent/FR2305435A1/en
Application granted granted Critical
Publication of FR2305435B3 publication Critical patent/FR2305435B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mercapto-substd. azole derivs. of formula (I) (where X is O, S, NH, NCH3 or NB in which B is benzyl or 4-methoxybenzyl; and R is -CH2OCH2COOR1, CH2OCH2CONR1R2 or CONR1R2 in which R1 and R2 are H or 1-4C alkyl R being other than CONH2 when X is NH, NCH3 or N-benzyl) e.g. 2-(carboxymethoxymethyl) 1,3,4-thiadiazole-5-thiol and their ammonium and alkali metal salts are new cpds. (I) are inters. for cephalosporins.
FR7608976A 1975-03-27 1976-03-26 Cephalosporin intermediate mercapto-substd azole derivs - prepd eg by cyclising N-acyl-dithiocarbazoic acids or their salts (BE270976) Granted FR2305435A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7512813A GB1542397A (en) 1975-03-27 1975-03-27 Cephem compounds
GB4044775 1975-10-02

Publications (2)

Publication Number Publication Date
FR2305435A1 true FR2305435A1 (en) 1976-10-22
FR2305435B3 FR2305435B3 (en) 1978-12-22

Family

ID=26249283

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7608976A Granted FR2305435A1 (en) 1975-03-27 1976-03-26 Cephalosporin intermediate mercapto-substd azole derivs - prepd eg by cyclising N-acyl-dithiocarbazoic acids or their salts (BE270976)

Country Status (12)

Country Link
JP (1) JPS51146467A (en)
AU (1) AU1244376A (en)
DD (1) DD124732A5 (en)
DE (1) DE2612761A1 (en)
DK (1) DK132776A (en)
FI (1) FI760794A (en)
FR (1) FR2305435A1 (en)
IL (1) IL49200A0 (en)
LU (1) LU74644A1 (en)
NO (1) NO761051L (en)
PT (1) PT64946B (en)
SE (1) SE7603700L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853196A1 (en) * 1978-12-07 1980-06-26 Schering Ag 1,3,4-THIADIAZOLE-2-CARBONIC ACID DERIVATIVES, METHOD FOR PRODUCING THESE COMPOUNDS AND THEIR FUNGICIDES AND NEMATICIDES CONTAINING THEM
US4230715A (en) * 1979-09-04 1980-10-28 Richardson-Merrell Inc. 1,2,4-Triazole-3-thiols as antisecretory agents

Also Published As

Publication number Publication date
PT64946A (en) 1976-04-01
LU74644A1 (en) 1977-10-10
NO761051L (en) 1976-09-28
IL49200A0 (en) 1976-05-31
AU1244376A (en) 1977-10-06
DD124732A5 (en) 1977-03-09
DE2612761A1 (en) 1976-10-07
JPS51146467A (en) 1976-12-16
FR2305435B3 (en) 1978-12-22
DK132776A (en) 1976-09-28
SE7603700L (en) 1976-09-28
PT64946B (en) 1977-08-25
FI760794A (en) 1976-09-28

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Legal Events

Date Code Title Description
ST Notification of lapse