FR2313064A1 - Antidepressant 2-indenyloxymethyl-morpholine derivs - prepd. by acylation and cyclization of 1-indenyloxy-2-amino-propanol derivs - Google Patents

Antidepressant 2-indenyloxymethyl-morpholine derivs - prepd. by acylation and cyclization of 1-indenyloxy-2-amino-propanol derivs

Info

Publication number
FR2313064A1
FR2313064A1 FR7602414A FR7602414A FR2313064A1 FR 2313064 A1 FR2313064 A1 FR 2313064A1 FR 7602414 A FR7602414 A FR 7602414A FR 7602414 A FR7602414 A FR 7602414A FR 2313064 A1 FR2313064 A1 FR 2313064A1
Authority
FR
France
Prior art keywords
derivs
morpholine
indenyloxymethyl
indenyloxy
prepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7602414A
Other languages
French (fr)
Other versions
FR2313064B1 (en
Inventor
Masuo Murakami
Kozo Takahashi
Yuji Kawashira
Tadao Kojima
Kunihiro Niigata
Takashi Fujikura
Yoshihisa Nozaki
Shiro Tachikawa
Shinji Usuda
Soichi Kagami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2313064A1 publication Critical patent/FR2313064A1/en
Application granted granted Critical
Publication of FR2313064B1 publication Critical patent/FR2313064B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Morpholine derivs. of formula (I): (where R' and R3 are H lower alkyl or phenyl; R2 is H, lower alkyl, cycloalkyl, phenyl or benzyl; and one of the broken lines is a double bond and the other is a single bond), e.g. 2-(7-indenyloxymethyl)-4-isopropyl-morpholine, and their salts with pharmacologically non-toxic or utilisable acids have methamphetamine-like, stimulant and antireserpine activities and are useful as antidepressants.
FR7602414A 1975-01-29 1976-01-29 Antidepressant 2-indenyloxymethyl-morpholine derivs - prepd. by acylation and cyclization of 1-indenyloxy-2-amino-propanol derivs Granted FR2313064A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50012177A JPS5188972A (en) 1975-01-29 1975-01-29 22*77 indeniruokishimechiru **4 chikanmoruhorinjudotainoseiho

Publications (2)

Publication Number Publication Date
FR2313064A1 true FR2313064A1 (en) 1976-12-31
FR2313064B1 FR2313064B1 (en) 1979-03-16

Family

ID=11798132

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7602414A Granted FR2313064A1 (en) 1975-01-29 1976-01-29 Antidepressant 2-indenyloxymethyl-morpholine derivs - prepd. by acylation and cyclization of 1-indenyloxy-2-amino-propanol derivs

Country Status (2)

Country Link
JP (1) JPS5188972A (en)
FR (1) FR2313064A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57157693U (en) * 1981-03-28 1982-10-04
JPS5821680U (en) * 1981-08-04 1983-02-10 日本軽金属株式会社 Shoji glass installation structure
CN100402511C (en) * 2005-06-24 2008-07-16 山东大学 6-aryloxymethyl-4-aryl-3-morpholone derivative and its preparation method
WO2011130194A2 (en) 2010-04-12 2011-10-20 Supernus Pharmaceuticals Inc. Methods for producing viloxazine salts and novel polymorphs thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
JPS5188972A (en) 1976-08-04
FR2313064B1 (en) 1979-03-16
JPS5616789B2 (en) 1981-04-18

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Legal Events

Date Code Title Description
ST Notification of lapse