FR2442053A2 - Increasing antibacterial activity of cephalosporin derivs. - by combining with beta lactamase inhibiting penicillanic-S,S-di:oxide - Google Patents

Increasing antibacterial activity of cephalosporin derivs. - by combining with beta lactamase inhibiting penicillanic-S,S-di:oxide

Info

Publication number
FR2442053A2
FR2442053A2 FR7917043A FR7917043A FR2442053A2 FR 2442053 A2 FR2442053 A2 FR 2442053A2 FR 7917043 A FR7917043 A FR 7917043A FR 7917043 A FR7917043 A FR 7917043A FR 2442053 A2 FR2442053 A2 FR 2442053A2
Authority
FR
France
Prior art keywords
penicillanic
combining
oxide
antibacterial activity
beta lactamase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7917043A
Other languages
French (fr)
Other versions
FR2442053B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2442053A2 publication Critical patent/FR2442053A2/en
Application granted granted Critical
Publication of FR2442053B2 publication Critical patent/FR2442053B2/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The antibacterial effect of 7-(D-2- 4-ethylpiperazine-2,3-dione-1-carboxamido -2- 4-hydroxyph- enyl acetamido -3-(1-methyl-5-tetrazolyl thiomethyl)-3-deactoxyme- thyl-cephalosporamic acid (I) or its salts, is increased by combining it with a penicillanic-5,5-dioxide of formula (II) or its salts with bases. In the formulae, R1 is H or residue completing an ester which is easily hydrolysed in vivo. (I) is a known antibacterial. (II) are antibacterials and beta-lactamase inhibitors. The mixt. of (I) and (II) are useful esp. against ampicillin resistant strains of E. Coli and Bacteriods spp, and are effective at lower doses than either component individually.
FR7917043A 1977-06-07 1979-06-29 Increasing antibacterial activity of cephalosporin derivs. - by combining with beta lactamase inhibiting penicillanic-S,S-di:oxide Granted FR2442053A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80432077A 1977-06-07 1977-06-07
US87938178A 1978-02-21 1978-02-21
US89045178A 1978-03-29 1978-03-29
US96376378A 1978-11-27 1978-11-27

Publications (2)

Publication Number Publication Date
FR2442053A2 true FR2442053A2 (en) 1980-06-20
FR2442053B2 FR2442053B2 (en) 1982-12-10

Family

ID=27505824

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7917043A Granted FR2442053A2 (en) 1977-06-07 1979-06-29 Increasing antibacterial activity of cephalosporin derivs. - by combining with beta lactamase inhibiting penicillanic-S,S-di:oxide

Country Status (2)

Country Link
DE (1) DE2912511C2 (en)
FR (1) FR2442053A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1158639A (en) * 1978-12-11 1983-12-13 Eric M. Gordon 6-bromopenicillanic acid sulfone
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5236684A (en) * 1975-09-13 1977-03-22 Toyama Chem Co Ltd Process for preparation of novel penicillins and cephalosporins
FR2393804A1 (en) * 1977-06-07 1979-01-05 Pfizer 1,1-DIOXIDES OF PENICILLANIC ACID AND ITS ESTERS USEFUL AS B-LACTAMASE INHIBITORS
FR2420347A1 (en) * 1978-03-24 1979-10-19 Toyama Chemical Co Ltd NEW ANTIBACTERIAL COMPOSITION CONTAINING A CEPHALOSPORIN AND A B-LACTAMASE INHIBITOR COMPOUND CONTAINING A B-LACTAM CORE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5236684A (en) * 1975-09-13 1977-03-22 Toyama Chem Co Ltd Process for preparation of novel penicillins and cephalosporins
FR2393804A1 (en) * 1977-06-07 1979-01-05 Pfizer 1,1-DIOXIDES OF PENICILLANIC ACID AND ITS ESTERS USEFUL AS B-LACTAMASE INHIBITORS
FR2420347A1 (en) * 1978-03-24 1979-10-19 Toyama Chemical Co Ltd NEW ANTIBACTERIAL COMPOSITION CONTAINING A CEPHALOSPORIN AND A B-LACTAMASE INHIBITOR COMPOUND CONTAINING A B-LACTAM CORE

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1977 *

Also Published As

Publication number Publication date
DE2912511A1 (en) 1979-10-04
DE2912511C2 (en) 1982-06-24
FR2442053B2 (en) 1982-12-10

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