FR2290193A1 - Derives de n2-naphtalenesulfonyl-l-arginine, leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives de n2-naphtalenesulfonyl-l-arginine, leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2290193A1
FR2290193A1 FR7534105A FR7534105A FR2290193A1 FR 2290193 A1 FR2290193 A1 FR 2290193A1 FR 7534105 A FR7534105 A FR 7534105A FR 7534105 A FR7534105 A FR 7534105A FR 2290193 A1 FR2290193 A1 FR 2290193A1
Authority
FR
France
Prior art keywords
naphtalenesulfonyl
preparation
pharmaceutical compositions
compositions containing
arginine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7534105A
Other languages
English (en)
Other versions
FR2290193B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP49128775A external-priority patent/JPS51125053A/ja
Priority claimed from JP49128774A external-priority patent/JPS51125052A/ja
Priority claimed from JP49136695A external-priority patent/JPS51125051A/ja
Priority claimed from JP49136697A external-priority patent/JPS51125260A/ja
Priority claimed from JP50023268A external-priority patent/JPS5912662B2/ja
Priority claimed from JP50023635A external-priority patent/JPS5939423B2/ja
Priority claimed from JP50026768A external-priority patent/JPS5939424B2/ja
Priority claimed from JP2935775A external-priority patent/JPS51105046A/ja
Priority claimed from JP2935875A external-priority patent/JPS51105047A/ja
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Publication of FR2290193A1 publication Critical patent/FR2290193A1/fr
Publication of FR2290193B1 publication Critical patent/FR2290193B1/fr
Application granted granted Critical
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7534105A 1974-11-08 1975-11-07 Derives de n2-naphtalenesulfonyl-l-arginine, leur preparation et compositions pharmaceutiques les contenant Granted FR2290193A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP49128774A JPS51125052A (en) 1974-11-08 1974-11-08 Process for preparing n2-(5, 6, 7, 8-tetrahydro-1-0r-2- naphthalenesul fonyl) arginine amides or their acid adduct salts
JP49128775A JPS51125053A (en) 1974-11-08 1974-11-08 Process for preparing n2-(5, 6, 7, 8-tetrahydro-1-or-2- naphthalenesul fonyl) agrinine amides or their acid adduct salts
JP49136697A JPS51125260A (en) 1974-11-29 1974-11-29 Process for preparing n2- alkoxynaphthalenesulfonylarginine amides or their acid adduct salts
JP49136695A JPS51125051A (en) 1974-11-29 1974-11-29 Process for preparing n2-alkoxynaphthalenesulfonyl-arginine amides or their acid adduct salts
JP50023268A JPS5912662B2 (ja) 1975-02-25 1975-02-25 Ｎ↓２−ナフタレンスルホニルアルギニンアミド類またはその酸付加塩の製造法
JP50023635A JPS5939423B2 (ja) 1975-02-26 1975-02-26 Ｎ↓２−ナフタレンスルホニルアルギニンアミド類またはその酸付加塩の製造方法
JP50026768A JPS5939424B2 (ja) 1975-03-05 1975-03-05 Ｎ↓２−ナフタレンスルホニルアルギニンアミド類またはその酸付加塩の製造法
JP2935775A JPS51105046A (en) 1975-03-11 1975-03-11 n22 nafutarensuruhoniruarugininesuterurui mataha sonosanfukaennoseizoho
JP2935875A JPS51105047A (en) 1975-03-11 1975-03-11 n22 nafutarensuruhoniruarugininesuterurui mataha sonosanfukaennoseizoho

Publications (2)

Publication Number Publication Date
FR2290193A1 true FR2290193A1 (fr) 1976-06-04
FR2290193B1 FR2290193B1 (fr) 1978-08-18

Family

ID=27576753

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7534105A Granted FR2290193A1 (fr) 1974-11-08 1975-11-07 Derives de n2-naphtalenesulfonyl-l-arginine, leur preparation et compositions pharmaceutiques les contenant

Country Status (9)

Country Link
US (3) US4066758A (fr)
CA (1) CA1073914A (fr)
DE (1) DE2550088A1 (fr)
DK (1) DK498975A (fr)
FR (1) FR2290193A1 (fr)
GB (1) GB1516668A (fr)
NL (1) NL7512637A (fr)
NO (1) NO753733L (fr)
SE (1) SE431204B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0097630A2 (fr) * 1982-06-23 1984-01-04 KabiVitrum AB Dérivés de N-alpha-arylsulfonyl-p-guanidino-phénylalanine utiles comme inhibiteur de la thrombine
FR2559151A1 (fr) * 1984-02-06 1985-08-09 Mitsubishi Chem Ind Derives de l'arginine et sels d'addition d'acides correspondants pharmaceutiquement acceptables et compositions pharmaceutiques les contenant

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173630A (en) * 1974-11-08 1979-11-06 Mitsubishi Chemical Industries Limited N2 Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US4104392A (en) * 1974-11-08 1978-08-01 Mitsubishi Chemical Industries Ltd. N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof, and antithrombotic compositions and methods employing them
JPS61112018A (ja) * 1984-11-06 1986-05-30 Mitsubishi Chem Ind Ltd 線溶増強剤
US5371091A (en) * 1992-08-31 1994-12-06 Bristol-Myers Squibb Company Heteroaromatic amine thrombin inhibitors
US5332822A (en) * 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
WO2022175136A2 (fr) 2021-02-16 2022-08-25 Dsm Ip Assets B.V. Nouveaux inhibiteurs de lrat

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622615A (en) * 1968-11-06 1971-11-23 Parke Davis & Co N{11 -(p-tolylsulfonyl)-L-arginine esters

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3867447A (en) * 1972-08-25 1975-02-18 Du Pont Hydroxyguanidine O-carbamates
US3978045A (en) * 1973-08-13 1976-08-31 Mitsubishi Chemical Industries Ltd. N2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
NL165652C (nl) * 1973-08-13 1981-05-15 Mitsubishi Chem Ind Werkwijze ter bereiding van een preparaat met anti- trombosewerking en/of diagnosticum voor trombine in bloed op basis van l-argininederivaten, het gevormde preparaat, het gevormde diagnosticum en werkwijze ter bereiding van l-argininederivaten.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622615A (en) * 1968-11-06 1971-11-23 Parke Davis & Co N{11 -(p-tolylsulfonyl)-L-arginine esters

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0097630A2 (fr) * 1982-06-23 1984-01-04 KabiVitrum AB Dérivés de N-alpha-arylsulfonyl-p-guanidino-phénylalanine utiles comme inhibiteur de la thrombine
EP0097630A3 (en) * 1982-06-23 1984-07-04 Kabivitrum Ab New thrombin inhibiting compounds
US4537896A (en) * 1982-06-23 1985-08-27 Kabivitrum Ab Thrombin inhibiting arylsulfonyl guanidinophenylalanine amides
FR2559151A1 (fr) * 1984-02-06 1985-08-09 Mitsubishi Chem Ind Derives de l'arginine et sels d'addition d'acides correspondants pharmaceutiquement acceptables et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
US4066758A (en) 1978-01-03
SE431204B (sv) 1984-01-23
FR2290193B1 (fr) 1978-08-18
SE7512530L (sv) 1976-05-10
GB1516668A (en) 1978-07-05
DK498975A (da) 1976-05-09
NO753733L (fr) 1976-05-11
NL7512637A (nl) 1976-05-11
US4062963A (en) 1977-12-13
DE2550088A1 (de) 1976-05-20
US4049645A (en) 1977-09-20
CA1073914A (fr) 1980-03-18

Similar Documents

Publication Publication Date Title
FR2276832A1 (fr) Nouvelles compositions pharmaceutiques et leur preparation
BE801108A (fr) Nouveaux composes pyridopyrrolobenzheterocycliques leur preparation et compositions pharmaceutiques les contenant
MC1119A1 (fr) Derives de l'isoquinoleine,leur preparation et medicaments contenant ces substances
FR2346350A1 (fr) Nouveaux derives de piperazine et de piperidine, leur procede de preparation et les compositions pharmaceutiques les contenant
BE847368A (fr) Nouvelles compositions pharmaceutiques et leur preparation,
BE853422A (fr) Trans-hexahydro-pyrido-indoles, leur preparation et compositions pharmaceutiques les contenant
BE771493A (fr) Nouveaux derives de l'isoindoline, leur preparation et les compositionsqui les contiennent
BE778796A (fr) Derives des polymyxines, leur preparation et les compositions medicinales les contenant
BE776682A (fr) Nouveaux derives de l'isoindoline, leur preparation et les compositionsmedicinales qui les contiennent
FR2290193A1 (fr) Derives de n2-naphtalenesulfonyl-l-arginine, leur preparation et compositions pharmaceutiques les contenant
BE825458A (fr) Nouveaux derives de piperidine, leur procede de preparation et compositions pharmaceutiques les contenant
BE800311A (fr) Aminohalopyridines substituees, leur preparation et compositions en contenant
BE794226A (fr) Derives de la quinoleine, leur preparation et les medicaments qui en contiennent
BE848227A (fr) Nouveaux composes heterocycliques et compositions pharmaceutiques les contenant,
BE803474A (fr) Nouvelles 2-alkylamino-dihydropyridines, leur procede de preparation et compositions pharmaceutiques les contenant
BE815499A (fr) Compositions pharmaceutiques contenant des derives de triazolo-isoquinoleine
BE806854A (fr) Nouvelles urees tricycliques, leur preparation et les compositions pharmaceutiques en contenant
FR2310132A1 (fr) 14b-hydroxy-3-desoxycardenolides et analogues de ceux-ci, leur preparation et compositions pharmaceutiques les contenant
FR2340310A1 (fr) Hydrazinophtalazines substituees, leur preparation et compositions pharmaceutiques les contenant
BE777911A (fr) Nouveaux composes heterocycliques, leur preparation et compositions pharmaceutiques les contenant
IL43218A0 (en) New derivatives of 2-amino-indane,their preparation and pharmaceutical compositions containing them
BE786031A (fr) Nouveaux derives de la phenanthridine, leur preparation et les compositions medicinales qui les contiennent
BE827444A (fr) Nouveaux derives de la thyronamine, procede de preparation et compositions pharmaceutiques
BE793851A (fr) Nouveaux derives de l'isoindoline, leur preparation et les compositions medicinales qui les contiennent
FR2283670A1 (fr) Derives d'acides 19,20-bis-nor-prostanoique, leur preparation et compositions pharmaceutiques les contenant

Legal Events

Date Code Title Description
ST Notification of lapse