FR2283670A1 - Derives d'acides 19,20-bis-nor-prostanoique, leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives d'acides 19,20-bis-nor-prostanoique, leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2283670A1
FR2283670A1 FR7524666A FR7524666A FR2283670A1 FR 2283670 A1 FR2283670 A1 FR 2283670A1 FR 7524666 A FR7524666 A FR 7524666A FR 7524666 A FR7524666 A FR 7524666A FR 2283670 A1 FR2283670 A1 FR 2283670A1
Authority
FR
France
Prior art keywords
bis
preparation
pharmaceutical compositions
compositions containing
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7524666A
Other languages
English (en)
Other versions
FR2283670B1 (fr
Inventor
Umberto Valcavi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISTITUTO BIOCHIM
Original Assignee
ISTITUTO BIOCHIM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISTITUTO BIOCHIM filed Critical ISTITUTO BIOCHIM
Publication of FR2283670A1 publication Critical patent/FR2283670A1/fr
Application granted granted Critical
Publication of FR2283670B1 publication Critical patent/FR2283670B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
FR7524666A 1974-08-07 1975-08-07 Derives d'acides 19,20-bis-nor-prostanoique, leur preparation et compositions pharmaceutiques les contenant Granted FR2283670A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26111/74A IT1060366B (it) 1974-08-07 1974-08-07 Acidi 19.20 bis nor prostanoici come composti ipolipemici

Publications (2)

Publication Number Publication Date
FR2283670A1 true FR2283670A1 (fr) 1976-04-02
FR2283670B1 FR2283670B1 (fr) 1981-01-02

Family

ID=11218654

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7524666A Granted FR2283670A1 (fr) 1974-08-07 1975-08-07 Derives d'acides 19,20-bis-nor-prostanoique, leur preparation et compositions pharmaceutiques les contenant

Country Status (19)

Country Link
US (1) US4073938A (fr)
JP (1) JPS5819675B2 (fr)
AT (1) AT359214B (fr)
BE (1) BE832229A (fr)
CA (1) CA1084917A (fr)
CS (1) CS188965B2 (fr)
DD (1) DD121103A5 (fr)
DE (1) DE2535343C2 (fr)
DK (1) DK357975A (fr)
ES (1) ES440055A1 (fr)
FR (1) FR2283670A1 (fr)
GB (1) GB1523355A (fr)
IL (1) IL47761A (fr)
IT (1) IT1060366B (fr)
NL (1) NL178314C (fr)
PH (1) PH14954A (fr)
SE (1) SE420090B (fr)
SU (1) SU794003A1 (fr)
ZA (1) ZA754777B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239778A (en) * 1978-09-12 1980-12-16 The University Of Illinois Foundation Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation
US4374856A (en) * 1980-09-10 1983-02-22 The Upjohn Company Liver cytoprotection using PGE's
IT1190400B (it) * 1985-10-04 1988-02-16 Istituto Biochimico Italiano Derivati dell'acido 19,20-bis,nor-prostanoico ad attivita' antiulcera e anoressivca,procedimento per la loro preparazione e composizioni farmaceutiche
IT1205183B (it) * 1987-06-25 1989-03-15 Istituto Biochimico Italiano Derivati prostaglandinici,procedimenti per prepararli e composizioni farmaceutiche che li contengono
MXPA05007674A (es) * 2003-01-23 2005-09-22 Esperion Therapeutics Inc Compuestos de hidroxilo y composiciones para el manejo del colesterol y usos relacionados.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1027118A (fr) * 1972-04-03 1978-02-28 Martin J. Weiss 3-alkyle-2-(6-carboxyhexyle) cyclopentanones, acides et esters derives

Also Published As

Publication number Publication date
SU794003A1 (ru) 1981-01-07
ZA754777B (en) 1976-07-28
NL178314B (nl) 1985-10-01
IT1060366B (it) 1982-07-10
BE832229A (fr) 1975-12-01
IL47761A (en) 1979-07-25
ES440055A1 (es) 1977-07-16
SE420090B (sv) 1981-09-14
SE7508857L (sv) 1976-02-09
DE2535343C2 (de) 1983-08-04
NL178314C (nl) 1986-03-03
JPS5819675B2 (ja) 1983-04-19
DE2535343A1 (de) 1976-02-19
PH14954A (en) 1982-02-02
DK357975A (da) 1976-02-08
NL7509196A (nl) 1976-02-10
US4073938A (en) 1978-02-14
CS188965B2 (en) 1979-03-30
AT359214B (de) 1980-10-27
IL47761A0 (en) 1975-10-15
CA1084917A (fr) 1980-09-02
FR2283670B1 (fr) 1981-01-02
JPS51125043A (en) 1976-11-01
GB1523355A (en) 1978-08-31
DD121103A5 (fr) 1976-07-12
ATA616275A (de) 1980-03-15

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