FR2286654A1 - NEW CYCLIC DERIVATIVES OF ADENOSINE-MONOPHOSPHORIC ACID - Google Patents

NEW CYCLIC DERIVATIVES OF ADENOSINE-MONOPHOSPHORIC ACID

Info

Publication number
FR2286654A1
FR2286654A1 FR7530111A FR7530111A FR2286654A1 FR 2286654 A1 FR2286654 A1 FR 2286654A1 FR 7530111 A FR7530111 A FR 7530111A FR 7530111 A FR7530111 A FR 7530111A FR 2286654 A1 FR2286654 A1 FR 2286654A1
Authority
FR
France
Prior art keywords
adenosine
cyclic derivatives
new cyclic
monophosphoric acid
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7530111A
Other languages
French (fr)
Other versions
FR2286654B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11234874A external-priority patent/JPS5139695A/en
Priority claimed from JP318575A external-priority patent/JPS5176295A/en
Priority claimed from JP14893574A external-priority patent/JPS5176292A/en
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of FR2286654A1 publication Critical patent/FR2286654A1/en
Application granted granted Critical
Publication of FR2286654B1 publication Critical patent/FR2286654B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Pharmaceutically active compounds of the formula I and non-toxic salts thereof, in which n is an integer from 5 to 12, are prepared. This entails a corresponding 8-halo-cyclic-adenosine monophosphate or an inorganic or organic salt thereof being reacted with a linear alkyl amine of the formula CH3(CH2)nNH2 in which n is an integer from 5 to 12. The compounds have excellent biological and pharmacological activities, especially as PDE inhibitors and display increased membrane permeability.
FR7530111A 1974-10-01 1975-10-01 NEW CYCLIC DERIVATIVES OF ADENOSINE-MONOPHOSPHORIC ACID Granted FR2286654A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11234874A JPS5139695A (en) 1974-10-01 1974-10-01 SAIKURITSUKUADENOSHINMONOHOSUFUEITOJUDOTAINO SEIZOHOHO
JP318575A JPS5176295A (en) 1974-12-26 1974-12-26 ADENOSHINKANJOMONORINSANESUTERUJUDOTAINO SEIZOHOHO
JP14893574A JPS5176292A (en) 1974-12-27 1974-12-27 88 arukiruaminoadenoshin 365** kanjomonorinsanesuterumatahasonoennoseizohoho

Publications (2)

Publication Number Publication Date
FR2286654A1 true FR2286654A1 (en) 1976-04-30
FR2286654B1 FR2286654B1 (en) 1979-05-04

Family

ID=27275694

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7530111A Granted FR2286654A1 (en) 1974-10-01 1975-10-01 NEW CYCLIC DERIVATIVES OF ADENOSINE-MONOPHOSPHORIC ACID

Country Status (3)

Country Link
CH (1) CH610910A5 (en)
DE (1) DE2543596A1 (en)
FR (1) FR2286654A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3712885A (en) * 1968-09-10 1973-01-23 G Weimann Purine-ribofuranoside-3',5'-cyclophosphates and process for their preparation
FR2213777A1 (en) * 1973-01-16 1974-08-09 Voorhees John Nucleoside cyclic phosphate compsns. - for relieving skin proliferation diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1922172C3 (en) * 1969-04-30 1980-12-18 Boehringer Mannheim Gmbh, 6800 Mannheim S'-cyclophosphate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3712885A (en) * 1968-09-10 1973-01-23 G Weimann Purine-ribofuranoside-3',5'-cyclophosphates and process for their preparation
FR2213777A1 (en) * 1973-01-16 1974-08-09 Voorhees John Nucleoside cyclic phosphate compsns. - for relieving skin proliferation diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, vol. 12, no. 26, 1973, pages 5310 - 5319 *

Also Published As

Publication number Publication date
CH610910A5 (en) 1979-05-15
FR2286654B1 (en) 1979-05-04
DE2543596A1 (en) 1976-04-08

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Legal Events

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