FR2213777A1 - Nucleoside cyclic phosphate compsns. - for relieving skin proliferation diseases - Google Patents

Nucleoside cyclic phosphate compsns. - for relieving skin proliferation diseases

Info

Publication number
FR2213777A1
FR2213777A1 FR7401337A FR7401337A FR2213777A1 FR 2213777 A1 FR2213777 A1 FR 2213777A1 FR 7401337 A FR7401337 A FR 7401337A FR 7401337 A FR7401337 A FR 7401337A FR 2213777 A1 FR2213777 A1 FR 2213777A1
Authority
FR
France
Prior art keywords
dermatitis
formula
compsns
sch2ph
cyclic phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7401337A
Other languages
French (fr)
Other versions
FR2213777B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VOORHEES JOHN US
Original Assignee
VOORHEES JOHN US
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VOORHEES JOHN US filed Critical VOORHEES JOHN US
Publication of FR2213777A1 publication Critical patent/FR2213777A1/en
Application granted granted Critical
Publication of FR2213777B1 publication Critical patent/FR2213777B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pharmaceutical prepns. contg. a pharmaceutical carrier and a cpd. of formula (I) (where R1 is H or Me; R2 is H or Ph; R3 is Pr, i-Pr or Ph; R4 is H, Br, SMe or SCH2Ph; and X is O or CH2) formula (II) (where R1 and R2 are H or OH; Y is H or alkali metal; Z is H, SCH2Ph, SH, halogen 1-8C alkylthio or OH; and R4 is H or -CONHR5 in which R5 is Ph, CH2Ph or 1-8C alkyl) and/or formula (III) (where R1 is -CONH2, -CSNH2, -C(NH)NH2, -C(NH)NHOH, -CN or -COOMe; R1 and R2 are H or OH; and Y is H or an alkali metal) may be administered topically, by injection, intralesionally, intradermally, subcutaneously or orally for the relief of skin proliferation disorders such as psoriasis, atopic dermatitis, non-specific dermatitis, primary contact dermatitis, allergic contact dermatitis, basal or lamellar skin carcinoma, lamellar ichthyosis, epidermolytic hyperkeratosis, precancerous solar keratosis, non-cancerous keratosis, acne or seborrhoeic dermatitis in man or mange in domestic animals.
FR7401337A 1973-01-16 1974-01-15 Nucleoside cyclic phosphate compsns. - for relieving skin proliferation diseases Granted FR2213777A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32401273A 1973-01-16 1973-01-16
US42506373A 1973-12-17 1973-12-17

Publications (2)

Publication Number Publication Date
FR2213777A1 true FR2213777A1 (en) 1974-08-09
FR2213777B1 FR2213777B1 (en) 1978-01-06

Family

ID=26984232

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7401337A Granted FR2213777A1 (en) 1973-01-16 1974-01-15 Nucleoside cyclic phosphate compsns. - for relieving skin proliferation diseases

Country Status (3)

Country Link
BE (1) BE809833A (en)
DE (1) DE2401449A1 (en)
FR (1) FR2213777A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2286654A1 (en) * 1974-10-01 1976-04-30 Asahi Chemical Ind NEW CYCLIC DERIVATIVES OF ADENOSINE-MONOPHOSPHORIC ACID
EP0015584A2 (en) * 1979-03-12 1980-09-17 Kailash Kumar Dr. Prof. Gauri Nucleotides, methods for their preparation and medicaments

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2883M (en) * 1963-05-21 1964-11-02 Ile Auguil Soc Civ Medicinal product based on 3 ', 5'-cyclic adenosine phosphate.
NL6913671A (en) * 1968-09-10 1970-03-12
NL7003222A (en) * 1969-04-30 1970-11-03
DE2049638A1 (en) * 1969-10-10 1971-04-15 Agence Nationale De Valorisation De La Recherche (Anvar), Courbevoie (Frankreich) Isomeric nucleoside derivatives and processes for their preparation
FR2140126A1 (en) * 1971-06-01 1973-01-12 Int Chem & Nuclear Corp
LU66452A1 (en) * 1972-11-10 1973-02-01

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2883M (en) * 1963-05-21 1964-11-02 Ile Auguil Soc Civ Medicinal product based on 3 ', 5'-cyclic adenosine phosphate.
NL6913671A (en) * 1968-09-10 1970-03-12
NL7003222A (en) * 1969-04-30 1970-11-03
DE2049638A1 (en) * 1969-10-10 1971-04-15 Agence Nationale De Valorisation De La Recherche (Anvar), Courbevoie (Frankreich) Isomeric nucleoside derivatives and processes for their preparation
FR2140126A1 (en) * 1971-06-01 1973-01-12 Int Chem & Nuclear Corp
LU66452A1 (en) * 1972-11-10 1973-02-01

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS 80 (1974) 48.332p cite S. AFR. 72 07 740 (i.C.N.) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2286654A1 (en) * 1974-10-01 1976-04-30 Asahi Chemical Ind NEW CYCLIC DERIVATIVES OF ADENOSINE-MONOPHOSPHORIC ACID
EP0015584A2 (en) * 1979-03-12 1980-09-17 Kailash Kumar Dr. Prof. Gauri Nucleotides, methods for their preparation and medicaments
EP0015584A3 (en) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Nucleotides, methods for their preparation and medicaments

Also Published As

Publication number Publication date
BE809833A (en) 1974-07-16
FR2213777B1 (en) 1978-01-06
DE2401449A1 (en) 1974-07-25

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Legal Events

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