FR2249082A1 - Cephalexins with large spectrum antibiotic activity - obtd. from alpha-halophenylacetic acids and 7-amino-desoxycephalosporanic acid - Google Patents
Cephalexins with large spectrum antibiotic activity - obtd. from alpha-halophenylacetic acids and 7-amino-desoxycephalosporanic acidInfo
- Publication number
- FR2249082A1 FR2249082A1 FR7338476A FR7338476A FR2249082A1 FR 2249082 A1 FR2249082 A1 FR 2249082A1 FR 7338476 A FR7338476 A FR 7338476A FR 7338476 A FR7338476 A FR 7338476A FR 2249082 A1 FR2249082 A1 FR 2249082A1
- Authority
- FR
- France
- Prior art keywords
- alpha
- cephalexins
- amino
- acids
- desoxycephalosporanic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Cephalexins of formula (I): (where X is H, OH; X1 is H, Cl) is prepd. by a two-stage process in which (a) the 7-amino-4-carboxy-3-methyl-3-cephem or a salt is reacted with a cpd. of formula (II) (where Y is Cl, Br, I; Z is Cl, Br or the gp. -O.CO2.R1 where R1 is alkyl, phenyl, benzyl or the gp. (where A is C or S), then (b) treating the product of (a) with NH3 or a generator of NH3. Method avoids disadvantages of known processes, e.g. protection of the alpha-NH gp. of alpha-aminophenylacetic acids.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7338476A FR2249082A1 (en) | 1973-10-29 | 1973-10-29 | Cephalexins with large spectrum antibiotic activity - obtd. from alpha-halophenylacetic acids and 7-amino-desoxycephalosporanic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7338476A FR2249082A1 (en) | 1973-10-29 | 1973-10-29 | Cephalexins with large spectrum antibiotic activity - obtd. from alpha-halophenylacetic acids and 7-amino-desoxycephalosporanic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2249082A1 true FR2249082A1 (en) | 1975-05-23 |
FR2249082B3 FR2249082B3 (en) | 1976-09-17 |
Family
ID=9127053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7338476A Granted FR2249082A1 (en) | 1973-10-29 | 1973-10-29 | Cephalexins with large spectrum antibiotic activity - obtd. from alpha-halophenylacetic acids and 7-amino-desoxycephalosporanic acid |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2249082A1 (en) |
-
1973
- 1973-10-29 FR FR7338476A patent/FR2249082A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2249082B3 (en) | 1976-09-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |