DE59602236D1 - Process for the production of ascorbic acid - Google Patents

Process for the production of ascorbic acid

Info

Publication number
DE59602236D1
DE59602236D1 DE59602236T DE59602236T DE59602236D1 DE 59602236 D1 DE59602236 D1 DE 59602236D1 DE 59602236 T DE59602236 T DE 59602236T DE 59602236 T DE59602236 T DE 59602236T DE 59602236 D1 DE59602236 D1 DE 59602236D1
Authority
DE
Germany
Prior art keywords
ascorbic acid
production
acid
keto
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59602236T
Other languages
German (de)
Inventor
Ulrich Dr Fechtel
Karlheinz Wembacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of DE59602236D1 publication Critical patent/DE59602236D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Abstract

A process for the preparation of L-ascorbic acid by reacting 2-keto-L-gulonic acid with aqueous mineral acid in a solvent mixture containing an inert organic solvent, an aliphatic ketone and also an acid chloride.
DE59602236T 1995-12-16 1996-12-04 Process for the production of ascorbic acid Expired - Lifetime DE59602236D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19547073A DE19547073C1 (en) 1995-12-16 1995-12-16 L-Ascorbic acid prepn. in high yield

Publications (1)

Publication Number Publication Date
DE59602236D1 true DE59602236D1 (en) 1999-07-22

Family

ID=7780344

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19547073A Expired - Fee Related DE19547073C1 (en) 1995-12-16 1995-12-16 L-Ascorbic acid prepn. in high yield
DE59602236T Expired - Lifetime DE59602236D1 (en) 1995-12-16 1996-12-04 Process for the production of ascorbic acid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19547073A Expired - Fee Related DE19547073C1 (en) 1995-12-16 1995-12-16 L-Ascorbic acid prepn. in high yield

Country Status (6)

Country Link
US (1) US5744618A (en)
EP (1) EP0779285B1 (en)
JP (1) JPH09176145A (en)
KR (1) KR100483775B1 (en)
AT (1) ATE181325T1 (en)
DE (2) DE19547073C1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19547073C1 (en) * 1995-12-16 1996-11-14 Merck Patent Gmbh L-Ascorbic acid prepn. in high yield
US5998634A (en) * 1999-03-15 1999-12-07 The United States Of America As Represented By The Secretary Of The Interior One-step synthesis of vitamin-C (L-ascorbic acid)
DE19919203A1 (en) 1999-04-28 2000-11-02 Basf Ag Process for the preparation of L-ascorbic acid
DE19938980A1 (en) * 1999-08-19 2001-02-22 Basf Ag Process for the preparation of 2-keto-L-gulonic acid esters
DE19954511A1 (en) 1999-11-12 2001-05-17 Basf Ag Process for the preparation of alkali salts of L-ascorbic acid
DE10022518A1 (en) 2000-05-10 2001-11-15 Basf Ag Preparation of L-ascorbic acids by reacting 2-keto-L-gulonic acids or melt of 2-keto-L-gulonic acid alkyl esters under acid catalysis using water-miscible solvent(s)
CN1507440A (en) 2000-12-22 2004-06-23 �Ϻ���ͨ��ѧ Continuous process for producing L-ascorbic acid
JP2004516319A (en) * 2000-12-22 2004-06-03 イーストマン ケミカル カンパニー Method for producing ascorbic acid in the presence of sulfite
US6740762B2 (en) 2001-08-24 2004-05-25 Eastman Chemical Company Process for ascorbic acids using alkaline earth silicate catalysts
US6716997B1 (en) 2001-10-09 2004-04-06 Eastman Chemical Company Systems and methods for generation of ascorbic acid with reduced color
US6476239B1 (en) 2002-02-12 2002-11-05 Eastman Chemical Company Process for the preparation of ascorbic acid
US6872314B2 (en) * 2003-08-29 2005-03-29 Eastman Chemical Company Dewatering process
CN102424695A (en) * 2011-10-28 2012-04-25 安徽泰格生物技术股份有限公司 Sodium methyl gulonate and preparation method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2185383A (en) 1937-04-28 1940-01-02 Charles Pflzer & Company Preparation of levo-ascorbic acid
US2205567A (en) * 1938-07-15 1940-06-25 Warren Buckley Nonrefillable bottle closure
JPS4815931B1 (en) 1970-10-05 1973-05-18
JPS58177986A (en) 1982-04-09 1983-10-18 Shionogi & Co Ltd Production of l-ascorbic acid
CN86105960A (en) 1985-08-09 1987-05-13 鲁布里佐尔公司 Under substantially anhydrous conditions, prepare the L-xitix from 2-ketone-L-gulonic acid
DE3819045C2 (en) * 1987-06-08 1997-06-19 Takeda Chemical Industries Ltd Production of L-ascorbic acid
EP0324261A1 (en) 1988-01-06 1989-07-19 Pfizer Inc. Production of L-ascorbic acid from 2-keto-L-gulonic acid with an acid catalyst and a lipophilic surfactant having a low hydrophilic: lipophilic balance under substantially anhydrous conditions
FR2648136B1 (en) * 1989-06-12 1994-06-17 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF ASCORBIC ACID
JPH08188578A (en) * 1994-11-11 1996-07-23 Takeda Chem Ind Ltd Production of l-ascorbic acid
DE19547073C1 (en) * 1995-12-16 1996-11-14 Merck Patent Gmbh L-Ascorbic acid prepn. in high yield

Also Published As

Publication number Publication date
US5744618A (en) 1998-04-28
KR100483775B1 (en) 2005-11-25
DE19547073C1 (en) 1996-11-14
EP0779285B1 (en) 1999-06-16
KR970042536A (en) 1997-07-24
ATE181325T1 (en) 1999-07-15
JPH09176145A (en) 1997-07-08
EP0779285A1 (en) 1997-06-18

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