DE69021455D1 - Process for the production of ascorbic acid. - Google Patents
Process for the production of ascorbic acid.Info
- Publication number
- DE69021455D1 DE69021455D1 DE69021455T DE69021455T DE69021455D1 DE 69021455 D1 DE69021455 D1 DE 69021455D1 DE 69021455 T DE69021455 T DE 69021455T DE 69021455 T DE69021455 T DE 69021455T DE 69021455 D1 DE69021455 D1 DE 69021455D1
- Authority
- DE
- Germany
- Prior art keywords
- ascorbic acid
- sodium
- separation
- production
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Abstract
Process for the preparation of pure ascorbic acid from 2-keto-L-gulonic acid or its sodium salt, by carrying out the following successive steps: - esterification of 2-keto-L-gulonic acid or its sodium salt, - lactonisation to sodium ascorbate - optional separation of the sodium ascorbate - displacement of the ascorbic acid from its salt - separation of the sodium sulphate - separation and purification of the ascorbic acid from its methanolic or aqueous-methanolic solution.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR898907716A FR2648136B1 (en) | 1989-06-12 | 1989-06-12 | PROCESS FOR THE PREPARATION OF ASCORBIC ACID |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69021455D1 true DE69021455D1 (en) | 1995-09-14 |
DE69021455T2 DE69021455T2 (en) | 1996-02-01 |
DE69021455T3 DE69021455T3 (en) | 2001-02-22 |
Family
ID=9382598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69021455T Expired - Lifetime DE69021455T3 (en) | 1989-06-12 | 1990-06-11 | Process for the production of ascorbic acid. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5391770A (en) |
EP (1) | EP0403351B2 (en) |
JP (1) | JP2921927B2 (en) |
KR (1) | KR100210636B1 (en) |
AT (1) | ATE126223T1 (en) |
CA (1) | CA2018692C (en) |
DE (1) | DE69021455T3 (en) |
DK (1) | DK0403351T4 (en) |
ES (1) | ES2075887T5 (en) |
FR (1) | FR2648136B1 (en) |
GR (2) | GR3017085T3 (en) |
HU (1) | HU205754B (en) |
IE (1) | IE69381B1 (en) |
PT (1) | PT94354B (en) |
RU (1) | RU1833383C (en) |
YU (1) | YU48323B (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1036457C (en) * | 1991-10-01 | 1997-11-19 | 武田药品工业株式会社 | Method of producing lower alkyl 2-keto-L-ketogulonic acid ester |
EP0671405A1 (en) * | 1994-01-18 | 1995-09-13 | F. Hoffmann-La Roche Ag | Manufacture of esters of 2-keto-L-gulonic acid |
JPH08176133A (en) * | 1994-12-26 | 1996-07-09 | Takeda Chem Ind Ltd | Method for purifying l-ascorbic acid |
IL115564A (en) * | 1995-10-11 | 1999-06-20 | Yissum Res Dev Co | Process for the recovery of ascorbic acid from an aqueous feed solution |
DE19547073C1 (en) * | 1995-12-16 | 1996-11-14 | Merck Patent Gmbh | L-Ascorbic acid prepn. in high yield |
JP3976832B2 (en) * | 1996-04-30 | 2007-09-19 | ディーエスエム アイピー アセッツ ビー.ブイ. | Method for isolating 2-keto-L-gulonic acid |
IL119731A0 (en) * | 1996-12-01 | 1997-03-18 | Yissum Res Dev Co | A process for the production of erythorbic acid |
US5998634A (en) * | 1999-03-15 | 1999-12-07 | The United States Of America As Represented By The Secretary Of The Interior | One-step synthesis of vitamin-C (L-ascorbic acid) |
DE19919203A1 (en) | 1999-04-28 | 2000-11-02 | Basf Ag | Process for the preparation of L-ascorbic acid |
US6153791A (en) * | 1999-08-02 | 2000-11-28 | Archer-Daniels-Midland Company | Process for purifying 2-keto-L-gulonic acid |
US6902917B1 (en) * | 1999-08-03 | 2005-06-07 | Archer-Daniels-Midland Company | Process for recovery of organic acids from fermentration broths |
DE19938980A1 (en) * | 1999-08-19 | 2001-02-22 | Basf Ag | Process for the preparation of 2-keto-L-gulonic acid esters |
DE19954511A1 (en) | 1999-11-12 | 2001-05-17 | Basf Ag | Process for the preparation of alkali salts of L-ascorbic acid |
US6670505B1 (en) | 2000-03-07 | 2003-12-30 | Eastman Chemical Company | Process for the recovery of organic acids from aqueous solutions |
DE10022518A1 (en) | 2000-05-10 | 2001-11-15 | Basf Ag | Preparation of L-ascorbic acids by reacting 2-keto-L-gulonic acids or melt of 2-keto-L-gulonic acid alkyl esters under acid catalysis using water-miscible solvent(s) |
US6320061B1 (en) | 2000-06-05 | 2001-11-20 | Eastman Chemical Company | Solvent exchange process |
WO2002051826A1 (en) | 2000-12-22 | 2002-07-04 | Eastman Chemical Company | Continuous process for producing l-ascorbic acid |
EP1368329B1 (en) | 2000-12-22 | 2005-08-31 | Eastman Chemical Company | Process for producing ascorbic acid in the presence of a sulfit |
US6740762B2 (en) | 2001-08-24 | 2004-05-25 | Eastman Chemical Company | Process for ascorbic acids using alkaline earth silicate catalysts |
WO2003031427A1 (en) * | 2001-10-09 | 2003-04-17 | Eastman Chemical Company | Systems and methods for generation of ascorbic acid with reduced color |
US6716997B1 (en) | 2001-10-09 | 2004-04-06 | Eastman Chemical Company | Systems and methods for generation of ascorbic acid with reduced color |
DE10149869A1 (en) * | 2001-10-10 | 2003-04-24 | Basf Ag | Isolating salts of organic acids from fermentation broth, e.g. 2-keto-L-gulonate for production of Vitamin C, involves partial evaporative crystallization followed by displacement precipitation |
US6518454B1 (en) | 2001-10-12 | 2003-02-11 | Eastman Chemical Company | Preparation of esters of carboxylic acids |
US6476239B1 (en) | 2002-02-12 | 2002-11-05 | Eastman Chemical Company | Process for the preparation of ascorbic acid |
US7091375B2 (en) | 2002-11-11 | 2006-08-15 | Basf Aktiengesellschaft | Method for the production of 2=-keto-l-gulonic acid C4C10 alkyl esters |
US6872314B2 (en) * | 2003-08-29 | 2005-03-29 | Eastman Chemical Company | Dewatering process |
US7276621B2 (en) * | 2005-08-12 | 2007-10-02 | Eastman Chemical Company | Production of di-(2-ethylhexyl) terephthalate |
US7799942B2 (en) * | 2005-08-12 | 2010-09-21 | Eastman Chemical Company | Production of terephthalic acid di-esters |
US7741509B2 (en) * | 2007-01-30 | 2010-06-22 | Eastman Chemical Company | Conversion of terephthalic acid to Di-n-butyl terephthalate |
CN100545156C (en) * | 2007-04-10 | 2009-09-30 | 三达膜科技(厦门)有限公司 | Reclaim the production method of vitamins C and Gu Long acid in the vitamins C mother liquor |
CN101914079B (en) * | 2010-08-20 | 2012-06-06 | 安徽丰原发酵技术工程研究有限公司 | Method for producing vitamin C |
CN102424695A (en) * | 2011-10-28 | 2012-04-25 | 安徽泰格生物技术股份有限公司 | Sodium methyl gulonate and preparation method thereof |
CN111018814B (en) * | 2019-12-06 | 2022-11-08 | 石药集团维生药业(石家庄)有限公司 | Method for recycling vitamin C secondary mother liquor |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2265121A (en) * | 1933-10-25 | 1941-12-02 | Hoffmann La Roche | Process for the manufacture of levoascorbic acid |
FR779883A (en) * | 1933-10-25 | 1935-04-13 | Hoffmann La Roche | Process for preparing 1-ascorbic acid |
US2443583A (en) * | 1944-07-12 | 1948-06-15 | Hugh H Mottern | Manufacture of ascorbic acid |
FR922949A (en) * | 1946-02-26 | 1947-06-23 | Bataafsche Petroleum | Process for preparing ascorbic acid from esters of ketogulonic acid |
JPS6019285B2 (en) * | 1977-02-07 | 1985-05-15 | 武田薬品工業株式会社 | Sorting method |
PL130761B1 (en) * | 1980-07-18 | 1984-09-29 | Krakowskie Zaklady Pharma | Process for preparing 1-ascorbic acid from its salts |
JPS58177986A (en) * | 1982-04-09 | 1983-10-18 | Shionogi & Co Ltd | Production of l-ascorbic acid |
JP3433820B2 (en) * | 1993-05-07 | 2003-08-04 | 関西電力株式会社 | Gas combustion device and gas combustion system |
-
1989
- 1989-06-12 FR FR898907716A patent/FR2648136B1/en not_active Expired - Lifetime
-
1990
- 1990-06-08 RU SU904830021A patent/RU1833383C/en active
- 1990-06-11 DK DK90401592T patent/DK0403351T4/en active
- 1990-06-11 EP EP90401592A patent/EP0403351B2/en not_active Expired - Lifetime
- 1990-06-11 IE IE209590A patent/IE69381B1/en not_active IP Right Cessation
- 1990-06-11 JP JP2150081A patent/JP2921927B2/en not_active Expired - Lifetime
- 1990-06-11 YU YU113690A patent/YU48323B/en unknown
- 1990-06-11 AT AT90401592T patent/ATE126223T1/en not_active IP Right Cessation
- 1990-06-11 DE DE69021455T patent/DE69021455T3/en not_active Expired - Lifetime
- 1990-06-11 ES ES90401592T patent/ES2075887T5/en not_active Expired - Lifetime
- 1990-06-11 HU HU903799A patent/HU205754B/en unknown
- 1990-06-11 CA CA002018692A patent/CA2018692C/en not_active Expired - Lifetime
- 1990-06-11 KR KR1019900008530A patent/KR100210636B1/en not_active IP Right Cessation
- 1990-06-12 PT PT94354A patent/PT94354B/en not_active IP Right Cessation
-
1993
- 1993-12-23 US US08/171,988 patent/US5391770A/en not_active Expired - Lifetime
-
1995
- 1995-08-10 GR GR950400344T patent/GR3017085T3/en unknown
-
2000
- 2000-08-03 GR GR20000401816T patent/GR3034121T3/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT94354B (en) | 2001-06-29 |
FR2648136A1 (en) | 1990-12-14 |
ES2075887T5 (en) | 2000-12-16 |
KR910000692A (en) | 1991-01-30 |
DE69021455T3 (en) | 2001-02-22 |
IE69381B1 (en) | 1996-09-04 |
EP0403351B2 (en) | 2000-08-23 |
DE69021455T2 (en) | 1996-02-01 |
HUT54131A (en) | 1991-01-28 |
HU205754B (en) | 1992-06-29 |
KR100210636B1 (en) | 1999-07-15 |
DK0403351T3 (en) | 1995-09-18 |
PT94354A (en) | 1991-02-08 |
YU48323B (en) | 1998-05-15 |
RU1833383C (en) | 1993-08-07 |
GR3017085T3 (en) | 1995-11-30 |
EP0403351B1 (en) | 1995-08-09 |
CA2018692A1 (en) | 1990-12-12 |
US5391770A (en) | 1995-02-21 |
JPH0324068A (en) | 1991-02-01 |
FR2648136B1 (en) | 1994-06-17 |
DK0403351T4 (en) | 2000-09-25 |
HU903799D0 (en) | 1990-11-28 |
YU113690A (en) | 1992-09-07 |
GR3034121T3 (en) | 2000-11-30 |
CA2018692C (en) | 2001-05-08 |
IE902095L (en) | 1990-12-12 |
JP2921927B2 (en) | 1999-07-19 |
ES2075887T3 (en) | 1995-10-16 |
ATE126223T1 (en) | 1995-08-15 |
EP0403351A1 (en) | 1990-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: RHONE-POULENC BIOCHEMIE, ANTONY, FR |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC |