FR2241321A1 - - Google Patents

Info

Publication number
FR2241321A1
FR2241321A1 FR7419512A FR7419512A FR2241321A1 FR 2241321 A1 FR2241321 A1 FR 2241321A1 FR 7419512 A FR7419512 A FR 7419512A FR 7419512 A FR7419512 A FR 7419512A FR 2241321 A1 FR2241321 A1 FR 2241321A1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7419512A
Other languages
French (fr)
Other versions
FR2241321B1 (enExample
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2241321A1 publication Critical patent/FR2241321A1/fr
Application granted granted Critical
Publication of FR2241321B1 publication Critical patent/FR2241321B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/0226—Quaternisation of polyalkylene(poly)amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
FR7419512A 1973-06-11 1974-06-06 Expired FR2241321B1 (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36903773A 1973-06-11 1973-06-11
US05/463,071 US4027009A (en) 1973-06-11 1974-04-23 Compositions and methods for depressing blood serum cholesterol

Publications (2)

Publication Number Publication Date
FR2241321A1 true FR2241321A1 (enExample) 1975-03-21
FR2241321B1 FR2241321B1 (enExample) 1977-11-04

Family

ID=27004423

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7419512A Expired FR2241321B1 (enExample) 1973-06-11 1974-06-06

Country Status (8)

Country Link
US (1) US4027009A (enExample)
CA (1) CA1028953A (enExample)
DE (1) DE2427924A1 (enExample)
FR (1) FR2241321B1 (enExample)
GB (1) GB1460515A (enExample)
IE (1) IE39406B1 (enExample)
IL (1) IL44967A (enExample)
NL (1) NL7407307A (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381079A1 (fr) * 1977-02-17 1978-09-15 Merck & Co Inc Compositions non-adhesives de polymeres quaternaires d'ionene, et leur procede de preparation
FR2500752A1 (fr) * 1981-03-02 1982-09-03 Mitsubishi Petrochemical Co Agent hypocholesterolemiant contenant une resine echangeuse d'anions ayant un groupe fonctionnel constitue par un sel d'imidazolium
EP0081291A3 (en) * 1981-11-04 1985-01-09 Kabushiki Kaisha Vitamin Kenkyusyo Polymer-metal complexes containing quaternary nitrogen atoms, process for preparation thereof and pharmaceutical agents comprising the same

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US4217429A (en) * 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4304910A (en) * 1978-05-04 1981-12-08 Kewanee Industries, Inc. Quarnary ammonium polymeric anti-microbial agent
US4325940A (en) * 1976-11-24 1982-04-20 Kewanee Industries, Inc. Anti-microbial, cosmetic and water-treating ionene polymeric compounds
IT1106718B (it) 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
US4239755A (en) * 1979-06-28 1980-12-16 The United States Of America As Represented By The Department Of Health, Education And Welfare Steroidal cyclotriphosphazenes
US4837005A (en) * 1986-09-30 1989-06-06 Union Carbide Corporation Partially hydrolyzed, poly(N-acyl)alkylenimines in personal care
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
US5260305A (en) * 1988-12-12 1993-11-09 E. R. Squibb & Sons, Inc. Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination
DE59300925D1 (de) * 1992-03-28 1995-12-21 Hoechst Ag Arzneimittel aus Polyhydroxymethylenderivaten, Verfahren zu deren Herstellung und Verwendung.
US5556619A (en) * 1992-08-20 1996-09-17 The Du Pont Merck Pharmaceutical Company Crosslinked polymeric ammonium salts
RU95107405A (ru) * 1992-08-20 1997-02-10 Е. И. Дюпон Де Немур энд Компани (US) Сшитая полимерная аммониевая соль, фармацевтическая композиция, способ снижения содержания холестерина в плазме крови, способ усиления экскреции желчных кислот
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
US5498678A (en) * 1992-12-21 1996-03-12 Rohm And Haas Company Suspension polymerization process for water-soluble monomers
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
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US6203785B1 (en) * 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
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US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
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ATE469645T1 (de) * 2002-10-23 2010-06-15 Bristol Myers Squibb Co Auf glycinnitril basierende hemmer der dipeptidylpeptidase iv
US7098235B2 (en) * 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
DE10261067A1 (de) * 2002-12-24 2004-08-05 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Cholesterinsenkendes Mittel, enthaltend eine n-3-Fettsäure
DE10261061A1 (de) * 2002-12-24 2004-07-15 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Diätetisches Lebensmittel zur positiven Beeinflussung der kardiovaskulären Gesundheit
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US7557143B2 (en) * 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
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US6995183B2 (en) * 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
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US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
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Publication number Priority date Publication date Assignee Title
FR2381079A1 (fr) * 1977-02-17 1978-09-15 Merck & Co Inc Compositions non-adhesives de polymeres quaternaires d'ionene, et leur procede de preparation
FR2500752A1 (fr) * 1981-03-02 1982-09-03 Mitsubishi Petrochemical Co Agent hypocholesterolemiant contenant une resine echangeuse d'anions ayant un groupe fonctionnel constitue par un sel d'imidazolium
EP0081291A3 (en) * 1981-11-04 1985-01-09 Kabushiki Kaisha Vitamin Kenkyusyo Polymer-metal complexes containing quaternary nitrogen atoms, process for preparation thereof and pharmaceutical agents comprising the same

Also Published As

Publication number Publication date
FR2241321B1 (enExample) 1977-11-04
AU6976374A (en) 1975-12-04
GB1460515A (en) 1977-01-06
DE2427924A1 (de) 1975-01-02
IL44967A0 (en) 1974-09-10
US4027009A (en) 1977-05-31
NL7407307A (enExample) 1974-12-13
IE39406B1 (en) 1978-09-27
IE39406L (en) 1974-12-11
IL44967A (en) 1977-10-31
CA1028953A (en) 1978-04-04

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