FR2215964A2 - Compsns. contg. 2-amino-4-hydroxy-7,8-dihydropteridines - as potentiators for microbiocidal agents - Google Patents
Compsns. contg. 2-amino-4-hydroxy-7,8-dihydropteridines - as potentiators for microbiocidal agentsInfo
- Publication number
- FR2215964A2 FR2215964A2 FR7403215A FR7403215A FR2215964A2 FR 2215964 A2 FR2215964 A2 FR 2215964A2 FR 7403215 A FR7403215 A FR 7403215A FR 7403215 A FR7403215 A FR 7403215A FR 2215964 A2 FR2215964 A2 FR 2215964A2
- Authority
- FR
- France
- Prior art keywords
- compsns
- esp
- dihydropteridines
- potentiators
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PXZWKVIXSKSCFR-UHFFFAOYSA-N 7,8-dihydropterin Chemical class N1=CCNC2=C1C(=O)N=C(N)N2 PXZWKVIXSKSCFR-UHFFFAOYSA-N 0.000 title 1
- 230000003641 microbiacidal effect Effects 0.000 title 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 2
- MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 abstract 1
- 125000006083 1-bromoethyl group Chemical group 0.000 abstract 1
- NHZLNPMOSADWGC-UHFFFAOYSA-N 4-amino-N-(2-quinoxalinyl)benzenesulfonamide Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CN=C(C=CC=C2)C2=N1 NHZLNPMOSADWGC-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000003495 Coccidiosis Diseases 0.000 abstract 1
- 229940117937 Dihydrofolate reductase inhibitor Drugs 0.000 abstract 1
- 206010023076 Isosporiasis Diseases 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229960004050 aminobenzoic acid Drugs 0.000 abstract 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- LDBTVAXGKYIFHO-UHFFFAOYSA-N diaveridine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=CN=C(N)N=C1N LDBTVAXGKYIFHO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003166 dihydrofolate reductase inhibitor Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 244000144977 poultry Species 0.000 abstract 1
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical group N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 239000005460 tetrahydrofolate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB518773A GB1472054A (en) | 1973-02-01 | 1973-02-01 | Potentiated microbial compositions |
| GB518873 | 1973-02-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2215964A2 true FR2215964A2 (en) | 1974-08-30 |
| FR2215964B2 FR2215964B2 (enrdf_load_stackoverflow) | 1976-10-08 |
Family
ID=26239715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7403215A Granted FR2215964A2 (en) | 1973-02-01 | 1974-01-31 | Compsns. contg. 2-amino-4-hydroxy-7,8-dihydropteridines - as potentiators for microbiocidal agents |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS49102825A (enrdf_load_stackoverflow) |
| DE (1) | DE2404594A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2215964A2 (enrdf_load_stackoverflow) |
| IE (1) | IE41192B1 (enrdf_load_stackoverflow) |
| IL (1) | IL44124A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150218167A1 (en) * | 2010-06-18 | 2015-08-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Linked purine pterin hppk inhibitors useful as antibacterial agents |
| US11091509B2 (en) | 2016-10-11 | 2021-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HPPK inhibitors useful as antibacterial agents |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU77364A1 (enrdf_load_stackoverflow) * | 1977-05-18 | 1979-01-19 |
-
1974
- 1974-01-31 FR FR7403215A patent/FR2215964A2/fr active Granted
- 1974-01-31 IE IE177/74A patent/IE41192B1/xx unknown
- 1974-01-31 JP JP49013251A patent/JPS49102825A/ja active Pending
- 1974-01-31 DE DE2404594A patent/DE2404594A1/de not_active Withdrawn
- 1974-01-31 IL IL44124A patent/IL44124A/en unknown
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150218167A1 (en) * | 2010-06-18 | 2015-08-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Linked purine pterin hppk inhibitors useful as antibacterial agents |
| US9453019B2 (en) * | 2010-06-18 | 2016-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Linked purine pterin HPPK inhibitors useful as antibacterial agents |
| US11091509B2 (en) | 2016-10-11 | 2021-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HPPK inhibitors useful as antibacterial agents |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2215964B2 (enrdf_load_stackoverflow) | 1976-10-08 |
| IL44124A0 (en) | 1974-05-16 |
| IL44124A (en) | 1977-10-31 |
| IE41192L (en) | 1974-08-01 |
| DE2404594A1 (de) | 1974-08-15 |
| AU6515574A (en) | 1975-08-07 |
| IE41192B1 (en) | 1979-11-07 |
| JPS49102825A (enrdf_load_stackoverflow) | 1974-09-28 |
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