IE41192B1 - Potentiated microbial compositions - Google Patents

Potentiated microbial compositions

Info

Publication number
IE41192B1
IE41192B1 IE177/74A IE17774A IE41192B1 IE 41192 B1 IE41192 B1 IE 41192B1 IE 177/74 A IE177/74 A IE 177/74A IE 17774 A IE17774 A IE 17774A IE 41192 B1 IE41192 B1 IE 41192B1
Authority
IE
Ireland
Prior art keywords
compsns
esp
amt
potentiated
effective
Prior art date
Application number
IE177/74A
Other versions
IE41192L (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB518773A external-priority patent/GB1472054A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IE41192L publication Critical patent/IE41192L/en
Publication of IE41192B1 publication Critical patent/IE41192B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compsns for the investigation and treatment of microbial systems or infections contain (a) a potentiating amt of a cpd of formula (I): (where (i) R is substd phenoxyalkyl or CHO and R1 and R2 are lower alkyl or together form a spirocycloalkyl ring with 4-6C atoms outside the pteridine ring, or (ii) R is CH2Cl and R1=R2=Me, or (iii) R is 1-bromoethyl and R1=R2=n-Pr) and (b) an effective amt of p-aminobenzoic acid competitor (e.g. a sulphonamide) and/or a dihydrofolatereductase inhibitor (e.g. a pyrimidine deriv). The compsns have a synergistic activity against bacteria and protozoa which produce at least part of their own tetrahydrofolate cofactor. They can be used as pharmaceuticals and in diagnosis and microorganism identification. Certain combinations (esp. of (I), sulphaquinoxaline and diaveridin) are esp. effective against coccidiosis in poultry. [FR2215964A2]
IE177/74A 1973-02-01 1974-01-31 Potentiated microbial compositions IE41192B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB518773A GB1472054A (en) 1973-02-01 1973-02-01 Potentiated microbial compositions
GB518873 1973-02-01

Publications (2)

Publication Number Publication Date
IE41192L IE41192L (en) 1974-08-01
IE41192B1 true IE41192B1 (en) 1979-11-07

Family

ID=26239715

Family Applications (1)

Application Number Title Priority Date Filing Date
IE177/74A IE41192B1 (en) 1973-02-01 1974-01-31 Potentiated microbial compositions

Country Status (5)

Country Link
JP (1) JPS49102825A (en)
DE (1) DE2404594A1 (en)
FR (1) FR2215964A2 (en)
IE (1) IE41192B1 (en)
IL (1) IL44124A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77364A1 (en) * 1977-05-18 1979-01-19
WO2011159471A2 (en) * 2010-06-18 2011-12-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Linked purine pterin hppk inhibitors useful as antibacterial agents
CA3039997A1 (en) 2016-10-11 2018-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hppk inhibitors useful as antibacterial agents

Also Published As

Publication number Publication date
IL44124A0 (en) 1974-05-16
IE41192L (en) 1974-08-01
AU6515574A (en) 1975-08-07
IL44124A (en) 1977-10-31
JPS49102825A (en) 1974-09-28
FR2215964A2 (en) 1974-08-30
FR2215964B2 (en) 1976-10-08
DE2404594A1 (en) 1974-08-15

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