FR2183716A1 - Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants - Google Patents
Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxantsInfo
- Publication number
- FR2183716A1 FR2183716A1 FR7314310A FR7314310A FR2183716A1 FR 2183716 A1 FR2183716 A1 FR 2183716A1 FR 7314310 A FR7314310 A FR 7314310A FR 7314310 A FR7314310 A FR 7314310A FR 2183716 A1 FR2183716 A1 FR 2183716A1
- Authority
- FR
- France
- Prior art keywords
- cpds
- phenyl
- substd
- opt
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002249 anxiolytic agent Substances 0.000 title abstract 2
- 230000000949 anxiolytic effect Effects 0.000 title abstract 2
- 229940005530 anxiolytics Drugs 0.000 title abstract 2
- 229940035363 muscle relaxants Drugs 0.000 title abstract 2
- 239000003158 myorelaxant agent Substances 0.000 title abstract 2
- 229940125723 sedative agent Drugs 0.000 title abstract 2
- 239000000932 sedative agent Substances 0.000 title abstract 2
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 206010012373 Depressed level of consciousness Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 208000032140 Sleepiness Diseases 0.000 abstract 1
- 206010041349 Somnolence Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009291 secondary effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2114172 | 1972-05-05 | ||
| CH581473A CH571001A5 (enExample) | 1972-05-05 | 1973-04-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2183716A1 true FR2183716A1 (en) | 1973-12-21 |
| FR2183716B1 FR2183716B1 (enExample) | 1976-12-03 |
Family
ID=25698412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7314310A Granted FR2183716A1 (en) | 1972-05-05 | 1973-04-19 | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4947391A (enExample) |
| BE (1) | BE798677A (enExample) |
| CA (1) | CA999860A (enExample) |
| CH (1) | CH571001A5 (enExample) |
| DE (1) | DE2321705A1 (enExample) |
| FR (1) | FR2183716A1 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2290905A1 (fr) * | 1974-11-15 | 1976-06-11 | Upjohn Co | Nouvelle formulation pharmaceutique contenant une benzodiazepine |
| US4134976A (en) * | 1975-02-15 | 1979-01-16 | Roussel Uclaf | 1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones |
| WO2000069836A1 (en) * | 1999-05-14 | 2000-11-23 | Glaxo Group Limited | Short-acting benzodiazepines |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| US10195210B2 (en) | 2010-11-08 | 2019-02-05 | Paion Uk Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| US10472365B2 (en) | 2006-07-10 | 2019-11-12 | Paion Uk Limited | Short-acting benzodiazepine salts and their polymorphic forms |
| EP3730495A4 (en) * | 2017-12-28 | 2021-03-03 | Hangzhou Adamerck Pharmlabs Inc. | PYRIDYLIMIDAZOBENZODIAZEPINE PROPIONATE COMPOUND AND ITS MANUFACTURING AND USE THEREOF |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US3910946A (en) * | 1974-09-12 | 1975-10-07 | Upjohn Co | 4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines |
| US4044142A (en) | 1975-02-03 | 1977-08-23 | Roussel Uclaf | 1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones |
| SE422580B (sv) * | 1975-08-07 | 1982-03-15 | Hoffmann La Roche | Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar |
| US4185102A (en) | 1975-11-04 | 1980-01-22 | Roussel Uclaf | 1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones |
| JPS60202096A (ja) * | 1984-03-22 | 1985-10-12 | 日産自動車株式会社 | フオ−クリフトのフオ−ク移動装置 |
| DE3610848A1 (de) * | 1986-04-01 | 1987-10-15 | Boehringer Ingelheim Kg | Neue 1,4-diazepine |
| SU1681729A3 (ru) * | 1986-07-25 | 1991-09-30 | Берингер Ингельгейм Кг (Фирма) | Способ получени производных 1,4-бензодиазепина |
| CA2068500A1 (en) * | 1991-05-14 | 1992-11-15 | Roger M. Freidinger | 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings |
| WO1994026723A2 (en) * | 1993-05-14 | 1994-11-24 | Genentech, Inc. | ras FARNESYL TRANSFERASE INHIBITORS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2150732A1 (enExample) * | 1971-08-04 | 1973-04-13 | Upjohn Co |
-
1973
- 1973-04-19 FR FR7314310A patent/FR2183716A1/fr active Granted
- 1973-04-24 CH CH581473A patent/CH571001A5/fr not_active IP Right Cessation
- 1973-04-25 BE BE130386A patent/BE798677A/xx unknown
- 1973-04-28 DE DE2321705A patent/DE2321705A1/de active Pending
- 1973-05-04 CA CA170,487A patent/CA999860A/en not_active Expired
- 1973-05-07 JP JP48051065A patent/JPS4947391A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2150732A1 (enExample) * | 1971-08-04 | 1973-04-13 | Upjohn Co |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2290905A1 (fr) * | 1974-11-15 | 1976-06-11 | Upjohn Co | Nouvelle formulation pharmaceutique contenant une benzodiazepine |
| US4134976A (en) * | 1975-02-15 | 1979-01-16 | Roussel Uclaf | 1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones |
| WO2000069836A1 (en) * | 1999-05-14 | 2000-11-23 | Glaxo Group Limited | Short-acting benzodiazepines |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| US7435730B2 (en) | 1999-05-14 | 2008-10-14 | Cenes Limited | Short-acting benzodiazepines |
| US7473689B2 (en) | 1999-05-14 | 2009-01-06 | Cenes Limited | Short-acting benzodiazepines |
| US7485635B2 (en) | 1999-05-14 | 2009-02-03 | Cenes Limited | Short-acting benzodiazepines |
| US7528127B2 (en) | 1999-05-14 | 2009-05-05 | Cenes Limited | Short-acting benzodiazepines |
| US10961250B2 (en) | 2006-07-10 | 2021-03-30 | Paion Uk Limited | Short-acting benzodiazepine salts and their polymorphic forms |
| US10472365B2 (en) | 2006-07-10 | 2019-11-12 | Paion Uk Limited | Short-acting benzodiazepine salts and their polymorphic forms |
| US12365684B2 (en) | 2006-07-10 | 2025-07-22 | Paion Uk Limited | Short-acting benzodiazepine salts and their polymorphic forms |
| US10342800B2 (en) | 2010-11-08 | 2019-07-09 | Paion Uk Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| US10195210B2 (en) | 2010-11-08 | 2019-02-05 | Paion Uk Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| US12201637B2 (en) | 2010-11-08 | 2025-01-21 | Paion Uk Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| EP3730495A4 (en) * | 2017-12-28 | 2021-03-03 | Hangzhou Adamerck Pharmlabs Inc. | PYRIDYLIMIDAZOBENZODIAZEPINE PROPIONATE COMPOUND AND ITS MANUFACTURING AND USE THEREOF |
| US11919905B2 (en) | 2017-12-28 | 2024-03-05 | Hangzhou Adamerck Pharmlabs, Inc. | Substituted benzo[f]imidazo[1,2-a][1,4]diazepines as anesthetics |
Also Published As
| Publication number | Publication date |
|---|---|
| BE798677A (fr) | 1973-08-16 |
| FR2183716B1 (enExample) | 1976-12-03 |
| JPS4947391A (enExample) | 1974-05-08 |
| DE2321705A1 (de) | 1973-11-15 |
| CA999860A (en) | 1976-11-16 |
| CH571001A5 (enExample) | 1975-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |